Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays [0.03%]
基于高密度微电极阵列的人类脊髓功能区二维定位图绘制及正中带分离
Samantha M Russman,Daniel R Cleary,Youngbin Tchoe et al.
Samantha M Russman et al.
Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM is most commonly conducted by indirectly recording motor and somatosensory evoked potentials ...
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction [0.03%]
胰腺钟是胰腺纤维化进展和外分泌功能障碍的关键决定因素
Weiliang Jiang,Linzi Jin,Dapeng Ju et al.
Weiliang Jiang et al.
Chronic pancreatitis (CP) is characterized by progressive fibrosis and exocrine dysregulation, which have long been considered irreversible. As a peripheral oscillator, the pancreas harbors autonomous and self-sustained timekeeping systems ...
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages [0.03%]
新冠病毒通过感染脂肪细胞和巨噬细胞驱动人体脂肪组织的炎症反应
Giovanny J Martínez-Colón,Kalani Ratnasiri,Heping Chen et al.
Giovanny J Martínez-Colón et al.
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory sy...
Gastric dysfunction in patients with chronic nausea and vomiting syndromes defined by a noninvasive gastric mapping device [0.03%]
一种非侵入式胃部检测装置定义的慢性恶心呕吐综合征患者的胃功能障碍
Armen A Gharibans,Stefan Calder,Chris Varghese et al.
Armen A Gharibans et al.
Chronic nausea and vomiting syndromes (NVSs) are prevalent and debilitating disorders. Putative mechanisms include gastric neuromuscular disease and dysregulation of brain-gut interaction, but clinical tests for objectively defining gastric...
Miriam Manook,Reza Motallebzadeh,Gavin J Pettigrew
Miriam Manook
Graft-versus-host recognition by passenger donor lymphocytes within organ transplants can trigger host alloantibody production (Charmetant et al.).
Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis [0.03%]
依赖受体的液体相巨胞饮促进动脉泡沫细胞形成和动脉粥样硬化
Hui-Ping Lin,Bhupesh Singla,WonMo Ahn et al.
Hui-Ping Lin et al.
Accumulation of lipid-laden foam cells in the arterial wall plays a central role in atherosclerotic lesion development, plaque progression, and late-stage complications of atherosclerosis. However, there are still fundamental gaps in our kn...
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer [0.03%]
戈瑞德斯特兰逆转了乳腺癌中雌激素受体突变驱动的孕酮敏感性过高现象
Jackson Liang,Ellen Rei Ingalla,Xiaosai Yao et al.
Jackson Liang et al.
ESR1 (estrogen receptor 1) hotspot mutations are major contributors to therapeutic resistance in estrogen receptor-positive (ER+) breast cancer. Such mutations confer estrogen independence to ERα, providing a selective advantage in the pre...
Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment [0.03%]
用于早期检测肝纤维化和治疗反应的分子MRI量化细胞外甲醛对浓度
Yingying Ning,Iris Y Zhou,Jesse D Roberts Jr et al.
Yingying Ning et al.
Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is characterized by a buildup of extracellular matrix, which can progress to cirrhosis, hepatocellular carcinoma, liver failure, or death. Now, there a...
Monitoring gait at home with radio waves in Parkinson's disease: A marker of severity, progression, and medication response [0.03%]
居家帕金森病步态监测：一种严重程度、进展和药物反应标志物的方法——使用无线电波监测家中帕金森患者的步态：严重程度、进展及药物反应的指标
Yingcheng Liu,Guo Zhang,Christopher G Tarolli et al.
Yingcheng Liu et al.
Parkinson's disease (PD) is the fastest-growing neurological disease in the world. A key challenge in PD is tracking disease severity, progression, and medication response. Existing methods are semisubjective and require visiting the clinic...
Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation [0.03%]
移植术后 inverted direct allorecognition触发早期供者特异性抗体应答
Xavier Charmetant,Chien-Chia Chen,Sarah Hamada et al.
Xavier Charmetant et al.
The generation of antibodies against donor-specific major histocompatibility complex (MHC) antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that recipient's allospecific B cells receive help from T cells....