Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency [0.03%]
谷氨酸1型转运蛋白缺乏症中代谢调控的突触功能障碍和丘脑皮层过度同步化及其意识的保持
Karthik Rajasekaran,Qian Ma,Levi B Good et al.
Karthik Rajasekaran et al.
Individuals with glucose transporter type I deficiency (G1D) habitually experience nutrient-responsive epilepsy associated with decreased brain glucose. However, the mechanistic association between blood glucose concentration and brain exci...
Ahmed Haider,Chunyu Zhao,Lu Wang et al.
Ahmed Haider et al.
Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily el...
Response to comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk" [0.03%]
对“一种心血管结局的蛋白质组学替代标志物，可以敏感地检测出风险变化的多种机制”的评论回复
Stephen A Williams,Peter Ganz
Stephen A Williams
A 27-protein signature has been proposed to predict cardiovascular disease, and its applicability in some clinical decision-making situations is discussed.
Comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk" [0.03%]
对“一种心血管结局的蛋白质组学替代标志物，能够检测出多种风险变化机制”的评论
Mika Kivimäki,Aroon D Hingorani,Joni V Lindbohm
Mika Kivimäki
A 27-protein signature has been proposed to predict cardiovascular disease, but its applicability in clinical decision-making remains unclear.
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models [0.03%]
针对胰岛素依赖型糖尿病模型中具有胰岛素特异性的工程化Treg的抗原特异性及旁观者免疫抑制作用研究
Soo Jung Yang,Akhilesh K Singh,Travis Drow et al.
Soo Jung Yang et al.
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in preventing disease. However, the frequency of antig...
A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos [0.03%]
BRMS1基因组核苷酸多态性与肺腺癌转移的关系及干预措施的研究进展
Yuan Liu,Neel Chudgar,Brooke Mastrogiacomo et al.
Yuan Liu et al.
About 50% of patients with early-stage, surgically resected lung cancer will develop distant metastasis. There remains an unmet need to identify patients likely to develop recurrence and to design innovative therapies to decrease this risk....
SARS-CoV-2 3CLpro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376 [0.03%]
基于病毒的系统选择SARS-CoV-2 3CLpro突变体可使病毒对奈玛特韦、恩沙特韦和GC376产生抗性
Emmanuel Heilmann,Francesco Costacurta,Seyed Arad Moghadasi et al.
Emmanuel Heilmann et al.
Protease inhibitors are among the most powerful antiviral drugs. Nirmatrelvir is the first protease inhibitor specifically developed against the SARS-CoV-2 protease 3CLpro that has been licensed for clinical use. To identify mutations that ...
Facilitating early parent-infant emotional connection improves cortical networks in preterm infants [0.03%]
早期促进父母与婴儿的情感联系可以改善早产儿的大脑皮层网络连接性
Pauliina Yrjölä,Michael M Myers,Martha G Welch et al.
Pauliina Yrjölä et al.
Exposure to environmental adversities during early brain development, such as preterm birth, can affect early brain organization. Here, we studied whether development of cortical activity networks in preterm infants may be improved by a mul...
Randomized Controlled Trial
Science translational medicine. 2022 Sep 28;14(664):eabq4786. DOI:10.1126/scitranslmed.abq4786 2022
CAR T cells targeting Aspergillus fumigatus are effective at treating invasive pulmonary aspergillosis in preclinical models [0.03%]
靶向烟曲霉的CAR-T细胞可有效治疗侵袭性肺曲霉病（小鼠模型）
Michelle Seif,Tamara Katharina Kakoschke,Frank Ebel et al.
Michelle Seif et al.
Aspergillus fumigatus is a ubiquitous mold that can cause severe infections in immunocompromised patients, typically manifesting as invasive pulmonary aspergillosis (IPA). Adaptive and innate immune cells that respond to A. fumigatus are pr...
Jan Witowski,Laura Heacock,Beatriu Reig et al.
Jan Witowski et al.
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has a high sensitivity in detecting breast cancer but often leads to unnecessary biopsies and patient workup. We used a deep learning (DL) system to improve the overall accuracy...