Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir [0.03%]
利用基因组范围的CRISPR筛选技术鉴定针对潜伏HIV-1储存库的候选潜休眠逆转剂组合
Weiwei Dai,Fengting Wu,Natalie McMyn et al.
Weiwei Dai et al.
Reversing HIV-1 latency promotes killing of infected cells and is essential for cure strategies; however, no single latency reversing agent (LRA) or LRA combination have been shown to reduce HIV-1 latent reservoir size in persons living wit...
Jacqueline M Bliley,Daniel J Shiwarski,Adam W Feinberg
Jacqueline M Bliley
Three-dimensional (3D) bioprinting is a transformative technology for engineering tissues for disease modeling and drug screening and building tissues and organs for repair, regeneration, and replacement. In this Viewpoint, we discuss techn...
Translational gaps and opportunities for medical wearables in digital health [0.03%]
医疗可穿戴设备在数字健康中的转化差距与机遇
Shuai Xu,Joohee Kim,Jessica R Walter et al.
Shuai Xu et al.
A confluence of advances in biosensor technologies, enhancements in health care delivery mechanisms, and improvements in machine learning, together with an increased awareness of remote patient monitoring, has accelerated the impact of digi...
In-line miniature 3D-printed pressure-cycled ventilator maintains respiratory homeostasis in swine with induced acute pulmonary injury [0.03%]
内联微型3D打印压力循环通气机维持急性肺损伤所致猪呼吸稳态
William F Pritchard,John W Karanian,Chris Jung et al.
William F Pritchard et al.
The COVID-19 pandemic demonstrated the need for inexpensive, easy-to-use, rapidly mass-produced resuscitation devices that could be quickly distributed in areas of critical need. In-line miniature ventilators based on principles of fluidics...
Minimally invasive, sustained-release relaxin-2 microparticles reverse arthrofibrosis [0.03%]
微创且可持续释放的relaxin-2微粒逆转僵硬关节症病症病情发展症状加重等症状
Jack R Kirsch,Amanda K Williamson,Diana Yeritsyan et al.
Jack R Kirsch et al.
Substantial advances in biotherapeutics are distinctly lacking for musculoskeletal diseases. Musculoskeletal diseases are biomechanically complex and localized, highlighting the need for novel therapies capable of addressing these issues. A...
Ralph Weissleder
Ralph Weissleder
Biotechnology is essential to advance modern medicine and alleviate global health crises, yet commercialization is often wrought by competing forces.
Translating diagnostics and drug delivery technologies to low-resource settings [0.03%]
诊断和药物输送技术在医疗资源匮乏环境中的应用
Erin M Euliano,Alexandros A Sklavounos,Aaron R Wheeler et al.
Erin M Euliano et al.
Diagnostics and drug delivery technologies engineered for low-resource settings aim to meet their technical design specifications using strategies that are compatible with limited equipment, infrastructure, and operator training. Despite ma...
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis [0.03%]
工程人体小型骨骼用于标准化建模健康造血功能、白血病和实体瘤转移
Ani Grigoryan,Dimitra Zacharaki,Alexander Balhuizen et al.
Ani Grigoryan et al.
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical...
Translating musculoskeletal bioengineering into tissue regeneration therapies [0.03%]
骨科生物工程转化到组织再生疗法中
Alastair Khodabukus,Tyler Guyer,Axel C Moore et al.
Alastair Khodabukus et al.
Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have r...
NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice [0.03%]
NOS1基因突变导致低促性腺激素性性腺功能减退症并伴有感觉和认知缺陷，幼年小鼠中可逆转
Konstantina Chachlaki,Andrea Messina,Virginia Delli et al.
Konstantina Chachlaki et al.
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal N...