Evolution of inflammation and immunity in a dengue virus 1 human infection model [0.03%]
登革病毒1型感染的人体感染模型中的炎症和免疫的演变规律
Adam T Waickman,Joseph Q Lu,HengSheng Fang et al.
Adam T Waickman et al.
Dengue virus (DENV) infections are major causes of morbidity and mortality throughout the tropics and subtropics. More than 400 million infections are estimated to occur every year, resulting in nearly 100 million symptomatic infections and...
Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats [0.03%]
glucokinase激活剂的节律疗法可显著改善肥胖Zucker大鼠的代谢状况
Tobias Kroon,Therese Hagstedt,Ida Alexandersson et al.
Tobias Kroon et al.
Circadian rhythms play a critical role in regulating metabolism, including daily cycles of feeding/fasting. Glucokinase (GCK) is central for whole-body glucose homeostasis and oscillates according to a circadian clock. GCK activators (GKAs)...
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency [0.03%]
T细胞治疗性基因编辑可纠正CTLA-4功能不足问题
Thomas Andrew Fox,Benjamin Christopher Houghton,Lina Petersone et al.
Thomas Andrew Fox et al.
Heterozygous mutations in CTLA-4 result in an inborn error of immunity with an autoimmune and frequently severe clinical phenotype. Autologous T cell gene therapy may offer a cure without the immunological complications of allogeneic hemato...
Rabi Upadhyay,Dan R Littman
Rabi Upadhyay
An arthritogenic strain of Subdoligranulum in the gut elicits a local immune response, a precursor to systemic autoimmunity (Chriswell et al.).
Ambarish Pandey,Kershaw V Patel
Ambarish Pandey
Lower lean body mass associated with reduced cardiovascular reserve at rest and peak exercise in women but not men may underlie sex differences in heart failure with preserved ejection fraction (Diaz-Canestro et al.).
Lean body mass and the cardiovascular system constitute a female-specific relationship [0.03%]
心血管系统与瘦体重构成女性特异关系
Candela Diaz-Canestro,Brandon Pentz,Arshia Sehgal et al.
Candela Diaz-Canestro et al.
Recent evidence points toward a link between lean body mass (LBM) and cardiovascular capacity in women. This study aimed at determining the sex-specific relationship of LBM with central and peripheral circulatory variables in healthy women ...
Multispectral fluorine-19 MRI enables longitudinal and noninvasive monitoring of tumor-associated macrophages [0.03%]
多光谱氟化氢-19磁共振成像技术可实现纵向非侵入性监测肿瘤相关巨噬细胞
Davide Croci,Rui Santalla Méndez,Sebastian Temme et al.
Davide Croci et al.
High-grade gliomas, the most common and aggressive primary brain tumors, are characterized by a complex tumor microenvironment (TME). Among the immune cells infiltrating the glioma TME, tumor-associated microglia and macrophages (TAMs) cons...
Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease [0.03%]
APP瑞典突变在家族性阿尔茨海默病中的突触发生效应
Bo Zhou,Jacqueline G Lu,Alberto Siddu et al.
Bo Zhou et al.
Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer's disease (AD) probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ (aducanumab) was approved as an AD treatment; however, some Aβ ...
An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma [0.03%]
体外平台指导淋巴瘤复发/难治性疾病药物联合治疗
Jasmine Goh,Sanjay De Mel,Michal M Hoppe et al.
Jasmine Goh et al.
Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), combination treatment chosen for an individual patient is empirical, and response rates remain poor in individuals with chemothera...
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages [0.03%]
具有抗癌作用的人源mTOR抑制剂sapanisertib可有效抑制疟原虫的多种激酶和生活周期阶段
Lauren B Arendse,James M Murithi,Tarrick Qahash et al.
Lauren B Arendse et al.
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human "mammalian target of rapamycin" (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro...