An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression [0.03%]
基于全血基因表达的急性感染患者免疫功能障碍评分及分层研究
Eddie Cano-Gamez,Katie L Burnham,Cyndi Goh et al.
Eddie Cano-Gamez et al.
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigat...
Patricia K Nguyen,Sean M Wu
Patricia K Nguyen
Sex hormones may account for sex differences observed in the prevalence and susceptibility of ICI myocarditis (Zhang et al., this issue).
Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis [0.03%]
自身造血干细胞移植治疗多发性硬化后T细胞谱系更新的动态过程
Josefine Ruder,María José Docampo,Jordan Rex et al.
Josefine Ruder et al.
Autologous hematopoietic stem cell transplantation (aHSCT) is a highly effective treatment of multiple sclerosis (MS). It depletes autoreactive cells and subsequently renews adaptive immune cells. The possible proinflammatory potential of s...
Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis [0.03%]
激素疗法上调MANF并克服免疫检查点抑制剂心肌炎的性别易感性
Yaohua Zhang,Chengcao Sun,Yajuan Li et al.
Yaohua Zhang et al.
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti-program...
Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans [0.03%]
选择性降低肝移植后的供者反应性调节性T细胞限制了促进同种异体移植耐受的调节性T细胞治疗
Qizhi Tang,Joey Leung,Yani Peng et al.
Qizhi Tang et al.
Promoting immune tolerance to transplanted organs can minimize the amount of immunosuppressive drugs that patients need to take, reducing lifetime risks of mortality and morbidity. Regulatory T cells (Tregs) are essential for immune toleran...
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure [0.03%]
TRIM35介导的核PKM2降解削弱心肌细胞中GATA4/6并诱导P53促进心力衰竭
Maria Areli Lorenzana-Carrillo,Keshav Gopal,Nikole J Byrne et al.
Maria Areli Lorenzana-Carrillo et al.
Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that translocates to the nucleus to regulate transcription factors in different tissues or pathologic states. Although studied extensively in cancer, its biological role in the heart remains ...
In vitro and in vivo efficacy of tecovirimat against a recently emerged 2022 monkeypox virus isolate [0.03%]
Tecovirimat对近期出现的2022猴痘病毒分离株的体外和体内疗效
Bryce M Warner,Levi Klassen,Angela Sloan et al.
Bryce M Warner et al.
The recent emergence of the monkeypox virus (MPXV) in non-endemic countries has been designated a Public Health Emergency of International Concern by the World Health Organization. There are currently no approved treatments for MPXV infecti...
A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus [0.03%]
一种保护性抗体混合物可破坏拉沙病毒的密集糖萼屏蔽作用
Haoyang Li,Tierra Buck,Michelle Zandonatti et al.
Haoyang Li et al.
Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antiviral...
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum [0.03%]
来自类风湿关节炎高风险个体的克隆IgA和IgG自身抗体鉴定出一种引发关节炎的Subdoligranulum菌株
Meagan E Chriswell,Adam R Lefferts,Michael R Clay et al.
Meagan E Chriswell et al.
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that occurs with disease. However, the connection between the mu...
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia [0.03%]
针对难治性B细胞白血病CRISPR编辑的CAR19通用型T细胞I期临床试验
Giorgio Ottaviano,Christos Georgiadis,Soragia Athina Gkazi et al.
Giorgio Ottaviano et al.
Genome editing of allogeneic T cells can provide "off-the-shelf" alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T cell receptor α chain (TRAC) to prevent graft-versus-host disease (GVHD) and remo...