A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice [0.03%]
靶向肿瘤细胞因子建立的相互作用可激活CAR-T细胞并招募宿主T细胞对抗胶质母细胞瘤
Federico Rossari,Giorgia Alvisi,Melania Cusimano et al.
Federico Rossari et al.
Chimeric antigen receptor (CAR) T cells have shown limited efficacy against solid tumors because of poor tissue penetration, constrained activity, and early exhaustion due to the immunosuppressive tumor microenvironment (TME). Although stim...
Matteo Iannacone,Cristian G Beccaria,Lena Allweiss et al.
Matteo Iannacone et al.
Chronic hepatitis B virus (HBV) infection affects millions worldwide despite the availability of effective vaccines. The stability of HBV's genomic minichromosome (cccDNA) within hepatocytes, the persistence of integrated viral sequences ca...
Modeling lesion transition dynamics to clinically characterize patients with clade I mpox in the Democratic Republic of the Congo [0.03%]
建立病变转归动态模型以临床表征刚果民主共和国的Clade I马波拉痘病毒感染者
Takara Nishiyama,Fuminari Miura,Yong Dam Jeong et al.
Takara Nishiyama et al.
Coinciding with the global outbreak of clade IIb mpox virus (MPXV), the Democratic Republic of the Congo (DRC) recently experienced a rapid surge in mpox cases with clade I MPXV. On 14 August 2024, the World Health Organization declared the...
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity [0.03%]
juvenile特发性关节炎滑膜组织图谱揭示了与疾病严重程度相关的病理生态位
Chrissy Bolton,Christopher B Mahony,Elizabeth Clay et al.
Chrissy Bolton et al.
Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited u...
Growth arrest specific-6 and angiotoxin receptor-like signaling drive oral regenerative wound repair [0.03%]
口腔再生修复伤口愈合过程中增殖停滞特异性6和血管毒素受体样信号的作用
Michelle F Griffin,Jessica Cook,Annah Morgan et al.
Michelle F Griffin et al.
Rapid and scarless wound repair is a hallmark of the oral mucosa, yet the cellular and molecular mechanisms that enable this regeneration remain unclear. By comparing populations of murine oral mucosal fibroblasts (OMFs) and facial skin fib...
Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy [0.03%]
Richner-Henry综合征可以被描述为以自噬溶酶体途径功能障碍为特征的疾病
Kohji Kato,Yosuke Nishio,Kirsty J McMillan et al.
Kohji Kato et al.
Ritscher-Schinzel syndrome (RSS) is a congenital malformation syndrome characterized by cerebellar, cardiac, and craniofacial malformations and phenotypes associated with liver, skeletal, and kidney dysfunction. The genetic cause of RSS rem...
A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis [0.03%]
利用CRISPR激活开展全基因组范围的体内筛选鉴定出BACE1是肺癌脑转移的治疗弱点
Shawn C Chafe,Kui Zhai,Nikoo Aghaei et al.
Shawn C Chafe et al.
Brain metastasis occurs in up to 40% of patients with non-small cell lung cancer (NSCLC). Considerable genomic heterogeneity exists between the primary lung tumor and respective brain metastasis; however, the identity of the genes capable o...
A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy [0.03%]
阳离子聚合物驱动糖胺聚糖组装和分泌用于临床前骨关节炎治疗
Yishan Chen,Wei Sun,Ya Wen et al.
Yishan Chen et al.
Osteoarthritis (OA) affects nearly 500 million people worldwide and is characterized by an irreversible loss of glycosaminoglycans (GAGs) at articular cartilage surfaces, which are essential in maintaining cartilage mechanical properties an...
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus [0.03%]
表观遗传调控的干扰素信号抑制与系统性红斑狼疮的年龄相关改善有关
Rithwik Narendra,Hoang Van Phan,Sarah L Patterson et al.
Rithwik Narendra et al.
In the general population, aging is associated with an increase in systemic inflammation and chronic disease burden. However, in systemic lupus erythematosus (SLE), older age is uniquely associated with a decrease in disease activity, sugge...