A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae [0.03%]
持续的中性粒细胞相关免疫特征定义了新冠后的肺部后遗症
Peter M George,Anna Reed,Sujal R Desai et al.
Peter M George et al.
Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with se...
Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness [0.03%]
呼出气体代谢物的可视化揭示了急性心肺呼吸困难的不同诊断标志物
Wadah Ibrahim,Michael J Wilde,Rebecca L Cordell et al.
Wadah Ibrahim et al.
Acute cardiorespiratory breathlessness accounts for one in eight of all emergency hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid triage and treatment. Here, we sought to find and replicate d...
Ning Yin,Yi Liu,Capella Weems et al.
Ning Yin et al.
Lung adenocarcinoma (LUAD) is the most prevalent form of non-small cell lung cancer (NSCLC) and a leading cause of cancer death. Immune checkpoint inhibitors (ICIs) of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) signaling indu...
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment [0.03%]
来自饮食的代谢产物和粘液将肠道微生物群与细胞毒性癌症治疗后的发热联系起来
Zaker I Schwabkey,Diana H Wiesnoski,Chia-Chi Chang et al.
Zaker I Schwabkey et al.
Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant (n = 119), the fecal microbiome was characterized at ...
The RTS,S malaria vaccine: Current impact and foundation for the future [0.03%]
RTS,S疟疾疫苗：当前影响与未来展望基础
James G Beeson,Liriye Kurtovic,Clarissa Valim et al.
James G Beeson et al.
The RTS,S vaccine has recently been recommended for implementation as a childhood vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of vaccine protection and longevity, implementation considerations, and f...
APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression [0.03%]
APOE ε4基因型，淀粉样蛋白-β和性别相互作用以预测高APOE mRNA表达区域中的tau含量
Aylin Dincer,Charles D Chen,Nicole S McKay et al.
Aylin Dincer et al.
The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its relationship with tauopathy is less established. We investigated the relationship between APOE ε4 carrier status, regional amyloid-β (Aβ), ma...
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens [0.03%]
食物特异性免疫球蛋白A与对花生或鸡蛋变应原的自然耐受无相关性
Elise G Liu,Biyan Zhang,Victoria Martin et al.
Elise G Liu et al.
ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food alle...
Padmanee Sharma,James P Allison
Padmanee Sharma
Spatiotemporal immune monitoring in clinical trials and reverse translation will help to determine optimal combination immune therapies to cure cancer.
Juraj Adamik,Lisa H Butterfield
Juraj Adamik
Cancer vaccines have been shown clinically to drive tumor-reactive cell activation, proliferation, and effector function. Unfortunately, tumor eradication by treatment with cancer vaccines has been unsuccessful in many patients. Critical st...
Verena van der Heide,Etienne Humblin,Abishek Vaidya et al.
Verena van der Heide et al.
Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted...