Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model [0.03%]
TP53/CDKN2A双基因敲除的胃食管结合部类器官模型的构建及其多组学分析
Hua Zhao,Yulan Cheng,Andrew Kalra et al.
Hua Zhao et al.
Inactivation of the tumor suppressor genes tumor protein p53 (TP53) and cyclin-dependent kinase inhibitor 2A (CDKN2A) occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, because of a paucity of GEJ-specific disease m...
Ulrike Schimpf,Erika Caldas-Silveira,Ljudmila Katchan et al.
Ulrike Schimpf et al.
Close to half of the world's pregnancies are still unplanned, reflecting a clear unmet need in contraception. Ideally, a contraceptive would provide the high efficacy of hormonal treatments, without systemic side effects. Here, we studied t...
Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia [0.03%]
饮食酮体通过升高巨核细胞中的组蛋白乙酰化水平来缓解化疗诱导的血小板减少症
Sisi Xie,Chenyu Jiang,Meng Wu et al.
Sisi Xie et al.
Chemotherapy-induced thrombocytopenia (CIT) is a severe complication in patients with cancer that can lead to impaired therapeutic outcome and survival. Clinically, therapeutic options for CIT are limited by severe adverse effects and high ...
A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis [0.03%]
单细胞分析框架允许对多发性硬化症患者的脑脊液白细胞及其组织来源进行表征
Patrick Ostkamp,Marie Deffner,Andreas Schulte-Mecklenbeck et al.
Patrick Ostkamp et al.
Peripheral central nervous system (CNS)-infiltrating lymphocytes are a hallmark of relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only populate the healthy CNS parenchyma but also are suspected to contribut...
Sana Raoof,Razelle Kurzrock
Sana Raoof
Randomized control trials (RCTs) are required before drug and device approvals and have contributed to patient safety, but they have also increased the cost and time of regulatory assessments. We propose that using real-world evidence to co...
Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy [0.03%]
肿瘤内在的NLRP3-HSP70-TLR4轴驱动抗PD-1免疫治疗期间的前转移生态位发育和超进展
Balamayooran Theivanthiran,Nagendra Yarla,Tarek Haykal et al.
Balamayooran Theivanthiran et al.
The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome-heat shock protein 70 (HSP70) signaling axis is triggered by CD8+ T cell cytotoxicity and contributes to the development of adaptive resistance to ant...
Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection [0.03%]
循环细胞游离DNA的突变和甲基化的同时分析用于肝癌检测
Pei Wang,Qianqian Song,Jie Ren et al.
Pei Wang et al.
Cell-free DNA (cfDNA)-based liquid biopsy is a promising approach for the early detection of cancer. A major hurdle is the limited yield of cfDNA from one blood draw, limiting the use of most samples to one test of either mutation or methyl...
The mechanical regulation of RNA binding protein hnRNPC in the failing heart [0.03%]
心力衰竭中RNA结合蛋白hnRNPC的机械调节作用
Fabiana Martino,Nandan Mysore Varadarajan,Ana Rubina Perestrelo et al.
Fabiana Martino et al.
Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by reexpressing fetal contractile proteins via ...
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy [0.03%]
精准基因组编辑修复RBM20致病突变可挽救扩张型心肌病
Takahiko Nishiyama,Yu Zhang,Miao Cui et al.
Takahiko Nishiyama et al.
Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS-rich) domain, which mediates nuclear localization. These mutation...
CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis [0.03%]
在NASH中阻断CD47-SIRPα轴可促进肝巨噬细胞清除坏死性凋亡的肝细胞并减少肝纤维化
Hongxue Shi,Xiaobo Wang,Fang Li et al.
Hongxue Shi et al.
Necroptosis contributes to hepatocyte death in nonalcoholic steatohepatitis (NASH), but the fate and roles of necroptotic hepatocytes (necHCs) in NASH remain unknown. We show here that the accumulation of necHCs in human and mouse NASH live...