Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus [0.03%]
小鼠的绿光镇痛作用介导于视叶腹侧外侧核中鸦片肽类神经元的视觉激活
Yu-Long Tang,Ai-Lin Liu,Su-Su Lv et al.
Yu-Long Tang et al.
Green light exposure has been shown to reduce pain in animal models. Here, we report a vision-associated enkephalinergic neural circuit responsible for green light-mediated analgesia. Full-field green light exposure at an intensity of 10 lu...
A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria [0.03%]
一项显示全孢子疫苗针对地方性疟疾安全性和有效性的随机对照试验
Sodiomon B Sirima,Alphonse Ouédraogo,Alfred B Tiono et al.
Sodiomon B Sirima et al.
A highly effective malaria vaccine remains elusive despite decades of research. Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active, nonreplicating, whole parasite vaccine demonstrated safety and vaccine efficac...
Randomized Controlled Trial
Science translational medicine. 2022 Dec 7;14(674):eabj3776. DOI:10.1126/scitranslmed.abj3776 2022
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation [0.03%]
内皮CFTR的丧失驱动了肺感染中的屏障失效和水肿形成，并且可以通过增强CFTR来针对性治疗
Lasti Erfinanda,Lin Zou,Birgitt Gutbier et al.
Lasti Erfinanda et al.
Pneumonia is the most common cause of the acute respiratory distress syndrome (ARDS). Here, we identified loss of endothelial cystic fibrosis transmembrane conductance regulator (CFTR) as an important pathomechanism leading to lung barrier ...
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage [0.03%]
senolytic处理保留了在冷存储期间由于细胞衰老而丧失的胆道再生能力
Sofia Ferreira-Gonzalez,Tak Yung Man,Hannah Esser et al.
Sofia Ferreira-Gonzalez et al.
Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) contin...
A B1a-natural IgG-neutrophil axis is impaired in viral- and steroid-associated aspergillosis [0.03%]
与病毒和皮质类固醇相关的曲霉病中受损的B1a天然IgG-中性粒细胞轴
Nicole Sarden,Sarthak Sinha,Kyle G Potts et al.
Nicole Sarden et al.
The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple conditions can disrupt this resistance, leading to lethal invasive infections. Core processes of natural resistance and its breakdown are undefined. ...
The path to venetoclax resistance is paved with mutations, metabolism, and more [0.03%]
通向依维替康耐药的道路包括突变、代谢等变化
Graeme P Sullivan,Lyndsey Flanagan,Daniel Alencar Rodrigues et al.
Graeme P Sullivan et al.
Venetoclax is a B cell lymphoma 2 (BCL-2)-selective antagonist used to treat chronic lymphocytic leukemia (CLL) and acute myelogenous leukemia (AML). Although this has been a promising therapeutic option for these patients, many of these pa...
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge 1 year later [0.03%]
对SARS-CoV-2免疫化的幼年恒河猴一年后可抵御异源病毒的攻击
Emma C Milligan,Katherine Olstad,Caitlin A Williams et al.
Emma C Milligan et al.
The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet questions regarding the durability of vaccine efficacy, especiall...
Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer [0.03%]
化学诱导剪接新抗原减弱结肠癌前期模型中的肿瘤生长
Shingo Matsushima,Masahiko Ajiro,Kei Iida et al.
Shingo Matsushima et al.
Neoantigen production is a determinant of cancer immunotherapy. However, the expansion of neoantigen abundance for cancer therapeutics is technically challenging. Here, we report that the synthetic compound RECTAS can induce the production ...
Gene editing of human iPSCs rescues thrombophilia in hereditary antithrombin deficiency in mice [0.03%]
基因编辑的人源iPSC挽救了抗凝血酶缺乏小鼠的血液病
Liang V Tang,Yanyi Tao,Yuanzheng Feng et al.
Liang V Tang et al.
Hereditary antithrombin deficiency is caused by SERPINC1 gene mutations and predisposes to recurrent venous thromboembolism that can be life-threatening. Therefore, lifelong anticoagulation is required, which has side effects and may not be...