A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity [0.03%]
针对非连接蛋白-1的单克隆抗体通过调节细胞可塑性来抑制患者衍生模型中的纤维化
Natascha Roehlen,Antonio Saviano,Houssein El Saghire et al.
Natascha Roehlen et al.
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the t...
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling [0.03%]
人类β-防御素2通过限制回肠中中性粒细胞的浸润和抑制T细胞受体信号传导来改善急性GVHD
Tamina Rückert,Geoffroy Andrieux,Melanie Boerries et al.
Tamina Rückert et al.
Acute graft-versus-host disease (aGVHD), which is driven by allogeneic T cells, has a high mortality rate and limited treatment options. Human β-defensin 2 (hBD-2) is an endogenous epithelial cell-derived host-defense peptide. In addition ...
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis [0.03%]
针对Netherton综合征和特应性皮炎的KLK5和KLK7的双抗体抑制作用
Joseph Chavarria-Smith,Cecilia P C Chiu,Janet K Jackman et al.
Joseph Chavarria-Smith et al.
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal ...
Combination bezafibrate and nivolumab treatment of patients with advanced non-small cell lung cancer [0.03%]
贝扎夫ibrate和nivolumab联合治疗晚期非小细胞肺癌患者
Kentaro Tanaka,Kenji Chamoto,Sho Saeki et al.
Kentaro Tanaka et al.
Despite the success of cancer immunotherapies such as programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibitors, patients often develop resistance. New combination therapies with PD-1/PD-L1 inhibitors are needed to overcome this i...
A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates [0.03%]
单剂量ChAd3-MARV疫苗可快速并长期地保护非人类灵长类动物免受马堡病毒的侵害
Ruth Hunegnaw,Anna N Honko,Lingshu Wang et al.
Ruth Hunegnaw et al.
Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category A bioterrorism agent by the Centers for Disease Control and Prevention (CDC) and ...
A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells [0.03%]
一个具有多发性硬化保护作用的编码变异体揭示了HDAC7在调节T细胞中的重要作用
Pierre-Paul Axisa,Tomomi M Yoshida,Liliana E Lucca et al.
Pierre-Paul Axisa et al.
Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune diseases indicate that genes active in immune cells predominantly mediate risk. However, identification and functional characterization of causal var...
Markus F Neurath
Markus F Neurath
Targeting cytokines in inflammatory bowel disease (IBD) is a useful clinical approach. Potential therapies for IBD include regulatory T cell transfer to restore cytokine balance, blocking proinflammatory cytokines (e.g., IL-12 and IL-23) or...
Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice [0.03%]
内皮素阻断可预防急性肾损伤小鼠的长期心血管和肾脏后遗症
Alicja Czopek,Rebecca Moorhouse,Peter J Gallacher et al.
Alicja Czopek et al.
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An ac...
Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis [0.03%]
法尼醇X受体拮抗依赖于巨噬细胞的效应T淋巴细胞活化和进行性硬化性胆管炎的发展
Tiffany Shi,Astha Malik,Annika Yang Vom Hofe et al.
Tiffany Shi et al.
Immune-mediated bile duct epithelial injury and toxicity of retained hydrophobic bile acids drive disease progression in fibrosing cholangiopathies such as biliary atresia or primary sclerosing cholangitis. Emerging therapies include pharma...