CD200+ cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti-PD-1/PD-L1 therapy [0.03%]
肿瘤微环境中CD200+细胞毒性T淋巴细胞是有效抗PD-1 / PD-L1治疗的关键
Xinxin Wang,Haoran Zha,Wei Wu et al.
Xinxin Wang et al.
Anti-PD-1/PD-L1 therapy, either by anti-PD-1 antibody or anti-PD-L1 antibody, has efficacy by reinvigorating tumor-infiltrating CD8+ T cells in a subset of patients with cancer, but it has unequal effects on heterogeneous CD8+ T cell popula...
The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease [0.03%]
C-Abl抑制剂IkT-148009抑制遗传性和散发性帕金森病小鼠模型的神经退行性疾病
Senthilkumar S Karuppagounder,Hu Wang,Terence Kelly et al.
Senthilkumar S Karuppagounder et al.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded α-synuclein, which i...
Understanding respiratory microbiome-immune system interactions in health and disease [0.03%]
理解健康与疾病状态下呼吸系统微生物组与免疫系统的相互作用
Sara K Di Simone,Ina Rudloff,Claudia A Nold-Petry et al.
Sara K Di Simone et al.
Interactions between the developing microbiome and maturing immune system in early life are critical for establishment of a homeostasis beneficial to both host and commensals. The lung harbors a diverse community of microbes associated with...
Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii [0.03%]
导尿引起小鼠急性泌尿系统感染由膀胱内鲍曼不动杆菌引发
Jennie E Hazen,Gisela Di Venanzio,Scott J Hultgren et al.
Jennie E Hazen et al.
The antibiotic-resistant bacterium Acinetobacter baumannii is a leading cause of hospital-associated infections. Despite surveillance and infection control efforts, new A. baumannii strains are regularly isolated from health care facilities...
Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models [0.03%]
靶向Src可以重新激活焦亡以逆转肺癌和胰腺癌模型中的化学抗性
Liangping Su,Yitian Chen,Cheng Huang et al.
Liangping Su et al.
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strat...
Posttranslational modifications induce autoantibodies with risk prediction capability in patients with small cell lung cancer [0.03%]
翻译后的中文标题为：小细胞肺癌患者中的自身抗体具有风险预测能力，可由蛋白质翻译后修饰诱导得到
请注意，虽然这个翻译准确地传达了英文标题的意思，但在中文的学术环境中，可能会偏好一个更加流畅和简洁的表达。因此，一个可能更符合中文习惯的版本是："蛋白质翻译后修饰诱导产生具有风险预测能力的自身抗体于小细胞肺癌患者中" 或者 "小细胞肺癌患者中的风险预测相关自身抗体由蛋白质翻译后修饰引发"。不过，这两个版本都对原句做了一定程度上的重组以适应中文的语言习惯。
Kristin J Lastwika,Andrew Kunihiro,Joell L Solan et al.
Kristin J Lastwika et al.
Small cell lung cancer (SCLC) elicits the generation of autoantibodies that result in unique paraneoplastic neurological syndromes. The mechanistic basis for the formation of such autoantibodies is largely unknown but is key to understandin...
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models [0.03%]
阻断通用γ链细胞因子信号可以改善疾病模型中的T细胞介导的病理产生过程
Audrey Le Floc&#x;h,Kirsten Nagashima,Dylan Birchard et al.
Audrey Le Floc&#x;h et al.
The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to tho...
Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with cancer [0.03%]
癌症患者血浆DNA片段末端异常位置和序列的全基因组分析
Karan K Budhraja,Bradon R McDonald,Michelle D Stephens et al.
Karan K Budhraja et al.
Genome-wide fragmentation patterns in cell-free DNA (cfDNA) in plasma are strongly influenced by cellular origin due to variation in chromatin accessibility across cell types. Such differences between healthy and cancer cells provide the op...
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis [0.03%]
非酒精性脂肪肝炎中肝星状细胞的自分泌信号环路引起纤维化进展
Shuang Wang,Kenneth Li,Eliana Pickholz et al.
Shuang Wang et al.
Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis (NASH); however, there are no approved antifibrotic...
Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice [0.03%]
使用由SARS-CoV-2 S蛋白进化引导的抗原Span进行疫苗接种可保护小鼠免受病毒变体的感染
Yongliang Zhao,Wenjia Ni,Simeng Liang et al.
Yongliang Zhao et al.
SARS-CoV-2 continues to accumulate mutations to evade immunity, leading to breakthrough infections after vaccination. How researchers can anticipate the evolutionary trajectory of the virus in advance in the design of next-generation vaccin...