Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events [0.03%]
抗brolucizumab免疫反应作为罕见视网膜血管炎/视网膜血管阻塞不良事件的一个前提条件
Anette C Karle,Matthias B Wrobel,Stephan Koepke et al.
Anette C Karle et al.
In October 2019, Novartis launched brolucizumab, a single-chain variable fragment molecule targeting vascular endothelial growth factor A, for the treatment of neovascular age-related macular degeneration. In 2020, rare cases of retinal vas...
Restoring arm function with a soft robotic wearable for individuals with amyotrophic lateral sclerosis [0.03%]
用于肌萎缩侧索硬化症患者的软体机器人外骨骼上肢康复装置
Tommaso Proietti,Ciaran O&#x;Neill,Lucas Gerez et al.
Tommaso Proietti et al.
Despite promising results in the rehabilitation field, it remains unclear whether upper limb robotic wearables, e.g., for people with physical impairments resulting from neurodegenerative disease, can be made portable and suitable for every...
Robert M Califf,Peter W Marks
Robert M Califf
Adequate and well-controlled clinical trials remain critical tools for helping to bring benefit to patients in medical need.
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant [0.03%]
醛缩酶2常见酒精脸红基因变异相关的内皮功能障碍通过SGLT2抑制剂改善
Hongchao Guo,Xuan Yu,Yu Liu et al.
Hongchao Guo et al.
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as ALDH2*2 affects ∼8% of the world's population. Even in heterozygous carriers, this missense variant leads to a severe loss of ALDH2 enzymatic activity and has be...
Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma [0.03%]
放化疗后胶质母细胞瘤患者的循环髓系衍生抑制细胞诱导全身性淋巴细胞减少症
Subhajit Ghosh,Jiayi Huang,Matthew Inkman et al.
Subhajit Ghosh et al.
Severe and prolonged lymphopenia frequently occurs in patients with glioblastoma after standard chemoradiotherapy and has been associated with worse survival, but its underlying biological mechanism is not well understood. To address this, ...
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria [0.03%]
疟疾驱动的适应性类似功能性的CD56阴性NK细胞的扩张与临床疟疾免疫相关
Maureen Ty,Shenghuan Sun,Perri C Callaway et al.
Maureen Ty et al.
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan child...
Delineating epileptogenic networks using brain imaging data and personalized modeling in drug-resistant epilepsy [0.03%]
基于脑影像数据和个性化建模的难治性癫痫致痫网络定位研究进展
Huifang E Wang,Marmaduke Woodman,Paul Triebkorn et al.
Huifang E Wang et al.
Precise estimates of epileptogenic zone networks (EZNs) are crucial for planning intervention strategies to treat drug-resistant focal epilepsy. Here, we present the virtual epileptic patient (VEP), a workflow that uses personalized brain m...
Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models [0.03%]
靶向新脂质合成诱导脂肪毒性并损害小鼠胶质母细胞瘤模型的DNA损伤修复能力
Katharina M Eyme,Alessandro Sammarco,Roshani Jha et al.
Katharina M Eyme et al.
Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms that determine susceptibility to DNLS-targeted therapies remain unkn...
Cezmi A Akdis,Mübeccel Akdis,Scott D Boyd et al.
Cezmi A Akdis et al.
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here, we review the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, an...
Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons [0.03%]
多重表观基因组编辑MECP2以挽救雷特综合症神经元
Junming Qian,Xiaonan Guan,Bing Xie et al.
Junming Qian et al.
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by loss-of-function heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome in young females. Reactivation of the silent wild-type MECP2 allele...