Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function [0.03%]
免疫反应基因1上调介导的代谢重编程可改善供心保存及移植心脏功能
Ienglam Lei,Wei Huang,Pierre Emmanuel Noly et al.
Ienglam Lei et al.
Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for d...
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models [0.03%]
免疫毒素-αCD40治疗激活先天性和适应性免疫并产生持久的胶质母细胞瘤反应模型中的抗肿瘤反应
Scott Parker,Charlotte McDowall,Luis Sanchez-Perez et al.
Scott Parker et al.
D2C7-immunotoxin (IT), a dual-specific IT targeting wild-type epidermal growth factor receptor (EGFR) and mutant EGFR variant III (EGFRvIII) proteins, demonstrates encouraging survival outcomes in a subset of patients with glioblastoma. We ...
Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model [0.03%]
一种人源化小鼠模型中的花生过敏原抑制可预防过敏性休克事件发生
Nada S Alakhras,Jaeho Shin,Scott A Smith et al.
Nada S Alakhras et al.
Peanut-induced allergy is an immunoglobulin E (IgE)-mediated type I hypersensitivity reaction that manifests symptoms ranging from local edema to life-threatening anaphylaxis. Although there are treatments for symptoms in patients with alle...
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis [0.03%]
EphB2界定的肝细胞参与非酒精性脂肪肝病的发展进展
Yang Xiao,Kirill Batmanov,Wenxiang Hu et al.
Yang Xiao et al.
Current therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and e...
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria [0.03%]
抗疟疾的天然杀伤细胞效应功能诱导抗裂殖体抗体产生及与疟疾病免疫相关性研究
Dennis O Odera,James Tuju,Kennedy Mwai et al.
Dennis O Odera et al.
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ upon stimulation with antib...
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes [0.03%]
基于细胞色素P450 oxidoreductase的作用机制及磺脲类继发失效的逆转作用研究
Hitoshi Watanabe,Wen Du,Jinsook Son et al.
Hitoshi Watanabe et al.
Sulfonylureas (SUs) are effective and affordable antidiabetic drugs. However, chronic use leads to secondary failure, limiting their utilization. Here, we identify cytochrome b5 reductase 3 (Cyb5r3) down-regulation as a mechanism of seconda...
Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells [0.03%]
CSDE1位点的表观遗传修饰决定了新生肿瘤生成细胞免疫识别
Jiadi Lv,Yabo Zhou,Nannan Zhou et al.
Jiadi Lv et al.
Weak immunogenicity of tumor cells is a root cause for the ultimate failure of immunosurveillance and immunotherapy. Although tumor evolution can be shaped by immunoediting toward a less immunogenic phenotype, mechanisms governing the initi...
A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab [0.03%]
针对抗VEGF生物制剂brolucizumab免疫原性的根因分析
Jeffrey D Kearns,Paul Wassmann,Ufuk Olgac et al.
Jeffrey D Kearns et al.
Immunogenicity against intravitreally administered brolucizumab has been previously described and associated with cases of severe intraocular inflammation, including retinal vasculitis/retinal vascular occlusion (RV/RO). The presence of ant...
T Jessie Ge,Vasiliki Nataly Rahimzadeh,Kevin Mintz et al.
T Jessie Ge et al.
Smart toilets are a key tool for enabling precision health monitoring in the home, but such passive monitoring has ethical considerations.
Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis [0.03%]
一种抗TNF / IL-6双特异性纳米抗体化合物在类风湿关节炎转化模型中的累加疗效研究
Nadine Biesemann,Daniel Margerie,Christian Asbrand et al.
Nadine Biesemann et al.
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases affecting primarily the joints. Despite successful therapies including antibodies against tumor necrosis factor (TNF) and interleukin-6 (IL-6) receptor, only 20 to 30% ...