A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury [0.03%]
硫喷妥钠治疗放射性血脑屏障损伤的II期研究
Jinping Cheng,Jingru Jiang,Baixuan He et al.
Jinping Cheng et al.
Radiation-induced brain injury (RIBI) is a debilitating sequela after radiotherapy to treat head and neck cancer, and 20 to 30% of patients with RIBI fail to respond to or have contraindications to the first-line treatments of bevacizumab a...
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1 [0.03%]
一种高效的针对HIV-1阳性细胞的诱导凋亡激活剂
Carl J Balibar,Daniel J Klein,Beata Zamlynny et al.
Carl J Balibar et al.
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1 cure strategy. Some HIV-1...
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 [0.03%]
肥胖可促进BRCA1或BRCA2胚系突变携带女性的乳腺上皮DNA损伤
Priya Bhardwaj,Neil M Iyengar,Heba Zahid et al.
Priya Bhardwaj et al.
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI is a risk factor for women with a germline mutation in BRCA1 or B...
A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis [0.03%]
长效抗IL-8抗体可改善子宫内膜异位症的炎症和纤维化
Ayako Nishimoto-Kakiuchi,Izumi Sato,Kiyotaka Nakano et al.
Ayako Nishimoto-Kakiuchi et al.
Current pharmacological treatments for endometriosis are limited to hormonal agents that can relieve pain but cannot cure the disease. Therefore, the development of a disease-modifying drug for endometriosis is an unmet medical need. By stu...
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose [0.03%]
科兴同源疫苗加强免疫诱导的抗体反应受年龄影响
Bruno Andraus Filardi,Valter Silva Monteiro,Pedro Vellosa Schwartzmann et al.
Bruno Andraus Filardi et al.
The emergence of the SARS-CoV-2 Omicron sublineages resulted in increased transmission rates and reduced protection from vaccines. To counteract these effects, multiple booster strategies were used in different countries, although data comp...
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases [0.03%]
IRAK4抑制可减弱驱动炎症性皮肤病的病理过程
Stéphanie Lavazais,Manja Jargosch,Sonia Dupont et al.
Stéphanie Lavazais et al.
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-medi...
Data-driven longitudinal characterization of neonatal health and morbidity [0.03%]
数据驱动的新生儿健康和疾病的纵向特征分析
Davide De Francesco,Jonathan D Reiss,Jacquelyn Roger et al.
Davide De Francesco et al.
Although prematurity is the single largest cause of death in children under 5 years of age, the current definition of prematurity, based on gestational age, lacks the precision needed for guiding care decisions. Here, we propose a longitudi...
An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination [0.03%]
一种灭活的NDV-HXP-S新冠疫苗诱导的中和抗体的人体比例高于mRNA疫苗
Juan Manuel Carreño,Ariel Raskin,Gagandeep Singh et al.
Juan Manuel Carreño et al.
NDV-HXP-S is a recombinant Newcastle disease virus-based vaccine against SARS-CoV-2, which expresses an optimized (HexaPro) spike protein on its surface. The vaccine can be produced in embryonated chicken eggs using the same process as that...
Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy [0.03%]
小分子化合物ToSendanin逆转巨噬细胞介导的免疫抑制以克服胶质母细胞瘤对免疫治疗的耐药性
Fan Yang,Duo Zhang,Haowen Jiang et al.
Fan Yang et al.
T cell-based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This immune suppressive tumor microenvironment is largely driven by tumor-associated myeloid cel...