Donor-recipient mismatch at the SIRPA locus adversely affects kidney allograft outcomes [0.03%]
SIRPA基因座上的供受者不匹配会影响肾移植结果
Daqiang Zhao,Hehua Dai,Camila Macedo et al.
Daqiang Zhao et al.
Donor-recipient mismatches in histocompatibility antigens recognized by lymphoid cells have been demonstrated to adversely affect allograft outcomes. In contrast, it remains unclear whether mismatches sensed by innate myeloid cells have a s...
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer [0.03%]
全身给药的RNA结合和细胞穿透抗体将治疗性RNA靶向多种小鼠癌症模型
Elias Quijano,Diana Martinez-Saucedo,Zaira Ianniello et al.
Elias Quijano et al.
There is intense interest in the advancement of RNAs as rationally designed therapeutic agents, especially in oncology, where a major focus is to use RNAs to stimulate pattern recognition receptors to leverage innate immune responses. Howev...
Targeting SIRT2 induces MLH1 deficiency and boosts antitumor immunity in preclinical colorectal cancer models [0.03%]
靶向SIRT2可导致MLH1缺乏并增强预临床结直肠癌模型的抗肿瘤免疫反应
Qianling Gao,Lanlan Yang,Shubiao Ye et al.
Qianling Gao et al.
Low tumor mutation burden and an immunosuppressive tumor microenvironment (TME) of colorectal cancers (CRCs) contribute to resistance to immune-checkpoint inhibitors in patients. Understanding the mechanisms of cancer immune evasion will be...
S100A8/A9 perturbation in bone marrow blunts antitumor immunity by promoting protumorigenic myelopoiesis in mouse models [0.03%]
骨髓S100A8/A9诱导的促肿瘤髓细胞生成抑制小鼠抗肿瘤免疫反应
Wen Luo,Xingxing Su,Qiao Zhang et al.
Wen Luo et al.
S100A8/A9 plays a critical role in the formation of an immunosuppressive tumor microenvironment. Therefore, it is important to identify inhibitors targeting S100A8/A9 to enhance antitumor immunity. However, systemic targeting of S100A8/A9 i...
Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy [0.03%]
调节性T细胞可减轻肥厚型心肌病的慢性炎症和心脏纤维化
Ying-Jie Wang,Kamayani Singh,Adam B Lokman et al.
Ying-Jie Wang et al.
Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart muscle disorder. Although the biophysical mechanisms by which gene variants in sarcomeric proteins disrupt cardiomyocyte function are largely understood, the cellular and...
Myeloid MAS-driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers [0.03%]
小胶质细胞MAS驱动的巨噬细胞胞葬作用促进缺血应激下小鼠和人类肝脏炎症消退
Shuai Chen,Bingyuan Huang,Shanshan Li et al.
Shuai Chen et al.
Liver ischemia-reperfusion injury (LIRI) is an inevitable detrimental event after liver transplantation. The MAS receptor plays a protective role in various diseases. However, the specific roles of MAS in myeloid cell innate immunity and th...
Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease [0.03%]
针对急性查加斯病小鼠模型中的赖氨酰-tRNA合成酶的抗锥体虫喹唑啉类药物显示出部分疗效
Lindsay B Tulloch,Hugh Tawell,Annie E Taylor et al.
Lindsay B Tulloch et al.
The protozoan parasite Trypanosoma cruzi causes Chagas disease, which is among the deadliest parasitic infections in Latin America. Current therapies are toxic and lack efficacy against the chronic stage of infection; thus, new drugs are ur...
Myeloma interaction with bone marrow stromal cells suppresses ciliogenesis and osteogenic potential in myeloma bone disease [0.03%]
多发性骨髓瘤与骨髓基质细胞互作抑制多发性骨髓瘤骨病中的纤毛发生和成骨潜能
Ying Xie,Zhaoyun Liu,Qian Li et al.
Ying Xie et al.
Myeloma bone disease, a complication of multiple myeloma (MM), is characterized by impaired osteogenic function of bone marrow stromal cells (BMSCs) and can be an indicator of disease progression. The underlying mechanisms driving BMSC dysf...
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques [0.03%]
腺病毒和mRNA疫苗以及黏膜加强剂可以提高猕猴对流感病毒的保护效力
Catherine Jacob-Dolan,David Hope,Jinyan Liu et al.
Catherine Jacob-Dolan et al.
The clinically approved seasonal influenza vaccines provide only 10 to 60% efficacy, necessitating strategies to improve vaccine performance. Here, we explored strategies for improving influenza vaccine efficacy using gene-based vaccines an...
Neuronal HDAC3 knockdown promotes propriospinal detour pathway formation and locomotor recovery in a mouse model of spinal cord injury [0.03%]
脊髓损伤小鼠模型中神经元HDAC3敲低促进脊髓内绕行通路形成和运动功能恢复
Zhongyang Gao,Hongyuan Xing,Yifan Shen et al.
Zhongyang Gao et al.
Propriospinal detour pathways facilitate motor recovery after spinal cord injury (SCI). Here, through a screen of epigenetic modulators, we demonstrated that small interfering RNA (siRNA)-mediated knockdown of histone deacetylase 3, deliver...