Immature natural killer cells promote progression of triple-negative breast cancer [0.03%]
幼稚的自然杀伤细胞促进三阴性乳腺癌的发展
Gatha Thacker,Samantha Henry,Ajeya Nandi et al.
Gatha Thacker et al.
Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor microenvironment and are generally considered to be antitumorigenic. Using single-cell RNA sequencing and functional analysis of multiple triple-negative b...
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target [0.03%]
细胞胞液异亮氨酰-tRNA合成酶作为多靶点抗疟疾药物靶标有潜在吸引力
Eva S Istvan,Francisco Guerra,Matthew Abraham et al.
Eva S Istvan et al.
Development of antimalarial compounds into clinical candidates remains costly and arduous without detailed knowledge of the target. As resistance increases and treatment options at various stages of disease are limited, it is critical to id...
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice [0.03%]
单剂自扩增或非复制型mRNA-LNP疫苗可控制小鼠HPV相关肿瘤
Jamile Ramos da Silva,Karine Bitencourt Rodrigues,Guilherme Formoso Pelegrin et al.
Jamile Ramos da Silva et al.
As mRNA vaccines have proved to be very successful in battling the coronavirus disease 2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the development of potent vaccines against other infectious diseases an...
Erratum for Research Article "Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents" by I. Llorente et al [0.03%]
I. Llorente等发表的研究论文“患者衍生的以胶质细胞为主的增殖前体细胞可修复啮齿类动物因缺血性卒中和血管性痴呆引起的白质功能障碍”的勘误表
Published Erratum
Science translational medicine. 2023 Mar;15(685):eadh1451. DOI:10.1126/scitranslmed.adh1451 2023
Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy [0.03%]
促甲状腺激素受体信号恢复肌营养不良大鼠的肌肉干细胞再生功能
Valentina Taglietti,Kaouthar Kefi,Lea Rivera et al.
Valentina Taglietti et al.
Duchenne muscular dystrophy (DMD) is a severe and progressive myopathy leading to motor and cardiorespiratory impairment. We analyzed samples from patients with DMD and a preclinical rat model of severe DMD and determined that compromised r...
Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4- and PD-1-targeted immunotherapy [0.03%]
可溶型CTLA-4突变体能够缓解免疫治疗相关不良事件但保留了对CTLA-4和PD-1靶向免疫治疗的疗效
Mingyue Liu,Xu Wang,Xuexiang Du et al.
Mingyue Liu et al.
Immune checkpoint inhibitors (ICIs), such as nivolumab and ipilimumab, not only elicit antitumor responses in a wide range of human cancers but also cause severe immune-related adverse events (irAEs), including death. A largely unmet medica...
Simone Pecetta,Arindam Nandi,Charlie Weller et al.
Simone Pecetta et al.
The health of the planet is one objective of the United Nations' Sustainable Development Goals. Vaccines can affect not only human health but also planet health by reducing poverty, preserving microbial diversity, reducing antimicrobial res...
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins [0.03%]
一种细胞穿透肽通过阻断C9ORF72-重复RNA向细胞核外转运来降低二肽重复蛋白的神经毒性作用
Lydia M Castelli,Ya-Hui Lin,Alvaro Sanchez-Martinez et al.
Lydia M Castelli et al.
Hexanucleotide repeat expansions in C9ORF72 are the most common genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Studies have shown that the hexanucleotide expansions cause the noncanonical tr...
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia [0.03%]
维生素B5和琥珀酰辅酶A改善SF3B1突变型骨髓衰竭性无效红细胞生成现象
Syed A Mian,Céline Philippe,Eleni Maniati et al.
Syed A Mian et al.
Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with symptomatic anemia due to ineffective erythropoiesis that impedes their quality of life and increases morbidity. More than 80% of patients with MDS-RS harbor...
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis [0.03%]
口腔粘膜破裂触发类风湿关节炎中抗瓜氨酸细菌和人类蛋白质抗体反应
R Camille Brewer,Tobias V Lanz,Caryn R Hale et al.
R Camille Brewer et al.
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis...