Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis [0.03%]
哈钦森-夏科氏病小肠结肠炎的发病机制与神经无髓鞘化对肠上皮再生功能的影响密切相关
Zhen Zhang,Dorothy Lee,Lingya Liu et al.
Zhen Zhang et al.
Hirschsprung disease (HSCR) is a congenital condition characterized by the improper migration of enteric neural crest cells, leading to aganglionosis most commonly in the rectosigmoid colon. This severe and life-threatening disorder often r...
Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss [0.03%]
光学相干层析成像检测到的人耳内液失衡与听力损失相关性研究
Wihan Kim,Dorothy W Pan,Bong Jik Kim et al.
Wihan Kim et al.
Hearing loss and vertigo occur when there is an imbalance between the two inner ear fluids, endolymph and perilymph. The inner ear is a small delicate structure encased in dense bone deep in the base of the skull, making it challenging to i...
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice [0.03%]
组织驻留记忆性CD4⁺T细胞侵入进行性多发性硬化症的中枢神经系统，并促进小鼠慢性自身免疫反应
Aurora Pignata,David Frieser,Carmen Gonzalez-Fierro et al.
Aurora Pignata et al.
Preventing T cell migration to the central nervous system (CNS) has remarkable therapeutic effects in relapsing-remitting multiple sclerosis (RRMS) but is poorly effective against the progressive form (PMS). Disability progression in PMS li...
Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis [0.03%]
用于能量平衡调控而不会引起恶心或呕吐的hindbrain八肽神经胶质递质治疗靶点
Caroline E Geisler,Kylie S Chichura,Oleksandr Orativskyi et al.
Caroline E Geisler et al.
Glia play a dynamic role in central nutrient sensing and appetite regulation yet represent underexplored targets in treating dysregulated energy balance. Glia within the dorsal vagal complex of the hindbrain synthesize the anorexigenic pept...
Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets [0.03%]
对2009年甲型H1N1病毒的既往免疫可减少雪貂感染甲型H5N1病毒及发病的易感性
Katherine H Restori,Veronika Weaver,Devanshi R Patel et al.
Katherine H Restori et al.
Zoonotic infections with emerging influenza viruses occur in the context of population-wide immunity to seasonal strains. Because of the worldwide spread of highly pathogenic clade 2.3.4.4b H5N1 influenza viruses in wild birds, there have b...
Protective envelope dimer epitope-like antibodies are elicited against dengue virus in children after infection and vaccination [0.03%]
登革热感染和疫苗接种后儿童会引发保护性包膜二聚体表位类似抗体
Patrick I Mpingabo,Michelle Ylade,Rosemary A Aogo et al.
Patrick I Mpingabo et al.
Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the en...
Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease [0.03%]
一种工程化胶囊用于递送液态mRNA治疗肠道疾病的口服给药方法及预临床研究
Xiangang Huang,Chuang Liu,Shonit Nair Sharma et al.
Xiangang Huang et al.
Oral delivery of messenger RNA (mRNA) therapeutics could offer noninvasive and self-administered treatments and vaccinations. However, the development of oral mRNA therapeutics remains challenging because of the degradative conditions of th...
Complement is activated in patients with acute chest syndrome caused by sickle cell disease and represents a therapeutic target [0.03%]
血红蛋白S病急性胸部综合症患者的补体活化代表了潜在的治疗靶点
Satheesh Chonat,Jayre A Jones,Seema R Patel et al.
Satheesh Chonat et al.
Despite being the first genetic disease described, sickle cell disease (SCD) continues to result in severe complications. Of these complications, acute chest syndrome (ACS), a form of acute lung injury, leads all-cause mortality. However, t...