Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [0.03%]
在临床前模型中激活非遗传AHR-ELMSAN1轴可优化BET靶向疗法并抑制白血病干细胞
Xinyue Zhou,Steven Moreira,Cecilia Restelli et al.
Xinyue Zhou et al.
Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISP...
Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease [0.03%]
染色体Y丢失通过激活免疫检查点促进衰老细胞的聚集并导致肾功能障碍
Yohei Arai,Nicholas W Chavkin,Yuka Arai et al.
Yohei Arai et al.
The accumulation of senescent cells contributes to morbidity and mortality; however, common mechanisms underpinning this age-associated phenomenon remain elusive. Hematopoietic loss of the Y chromosome (LOY) is the most frequently acquired ...
Jing Li,Xuerui Wang,Andreas I Lackner et al.
Jing Li et al.
During pregnancy, immune responses must balance protection from infections with tolerance of the semiallogeneic fetus. However, the mechanisms regulating maternal-fetal tolerance remain poorly understood. Recently, we identified CD8+ T cell...
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial [0.03%]
一项一期临床试验表明，用编码膜锚定型HIV包膜三聚体的mRNA疫苗诱导出了广义二级中和抗体
K Rachael Parks,Zoe Moodie,Mary A Allen et al.
K Rachael Parks et al.
mRNA technology might accelerate development of an urgently needed preventive human immunodeficiency virus (HIV) vaccine. We evaluated the safety and immunogenicity of three mRNA-encoded envelope trimers, including two doses of soluble and ...
Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide [0.03%]
larazotide治疗儿童新冠后多系统炎症综合征的病毒刺突抗原清除和增强恢复效果研究
Lael M Yonker,Abigail S Kane,Zoe Swank et al.
Lael M Yonker et al.
Multisystem inflammatory syndrome (MIS) is a severe disease that occurs weeks to months after acute infection with SARS-CoV-2, often occurring in children (MISC). Symptoms include high fever, rash, nausea, diarrhea, and abdominal pain. Chil...
AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models [0.03%]
靶向AGPAT4的共价抑制剂可增强靶向疗法以克服肝细胞癌小鼠模型中的癌细胞的可塑性
Kai-Yu Ng,Tin-Yan Koo,Ianto Bosheng Huang et al.
Kai-Yu Ng et al.
The development of cancerous cells leads to considerable changes in metabolic processes to meet the demands of tumor growth. Tumor lineage plasticity has been identified as a key factor in therapy resistance and tumor recurrence. Herein, we...
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease [0.03%]
系统的分析细胞串扰揭示了SEMA6D-TREM2在调节阿尔茨海默病的小胶质细胞功能中的作用
Ricardo D&#x;Oliveira Albanus,Gina M Finan,Logan Brase et al.
Ricardo D&#x;Oliveira Albanus et al.
Cellular cross-talk, mediated by membrane receptors and their ligands, is crucial for brain homeostasis and can contribute to neurodegenerative diseases such as Alzheimer's disease (AD). To find cross-talk dysregulations involved in AD, we ...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models [0.03%]
基于mRNA编码的HIV膜结合型包膜三聚体诱导动物模型中产生中和抗体疫苗接种研究
Parham Ramezani-Rad,Christopher A Cottrell,Ester Marina-Zárate et al.
Parham Ramezani-Rad et al.
A protective vaccine against human immunodeficiency virus (HIV) will likely need to induce broadly neutralizing antibodies (bnAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine s...
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis [0.03%]
NFIA通过调节关节软骨细胞脂肪酸代谢维持关节稳态
Cuicui Wang,Liang Fang,Meng Shi et al.
Cuicui Wang et al.
Osteoarthritis (OA) is a joint disease with an etiology partially rooted in metabolic dysfunction, yet the underlying mechanisms in this context are not determined, limiting opportunities to develop therapeutic treatments. In this study, we...