Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers [0.03%]
滤泡调节性T细胞通过支持浆细胞从生发中心释放促进自身免疫性脑脊髓炎发生发展
Fanny Martinez,Coline Cotineau,Julien Novarino et al.
Fanny Martinez et al.
Follicular regulatory T cells (Tfr cells) constitute a subset of regulatory T cells pivotal to the immune response in germinal centers (GCs) that inhibit autoantibody production. Their role, however, remains ill-defined in autoimmune diseas...
Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression [0.03%]
抗原-Fc融合疗法可在无需全身免疫抑制的情况下降低疱疹性瘭疽模型的严重程度
Soheil Tavakolpour,Ali Nili,Leïla A Munaretto et al.
Soheil Tavakolpour et al.
Pemphigus vulgaris is a B cell-mediated autoimmune disease characterized by autoantibodies targeting desmoglein-3 (Dsg3), a critical adhesion molecule in epithelial tissues. Current treatments rely on broad immunosuppression, highlighting t...
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans [0.03%]
膳食饱和脂肪酸促进小鼠和人类肺髓样细胞炎性小体活化及介导的炎症反应
Sam J McCright,Olivia Harding,Julia Chini et al.
Sam J McCright et al.
Resident tissue macrophages and monocytes (RTMs) integrate local and systemic signals to coordinate immune cell function at homeostasis and in response to inflammatory stimuli. Obesity-associated metabolic dysfunction drives the development...
Immune response and clinical severity are shaped by skin-adapted Staphylococcus aureus in chronically infected patients [0.03%]
金黄色葡萄球菌引起的慢性感染患者的免疫反应和临床严重程度受皮肤适应性的影响
Anne Jamet,Xiali Fu,Céline Dietrich et al.
Anne Jamet et al.
Despite the well-described association of skin lesions with Staphylococcus aureus, the distinct ability of clinical isolates to influence the local and systemic inflammatory response in a patient-specific manner is insufficiently characteri...
CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice [0.03%]
CAR-Treg细胞在小鼠胰岛移植中的关联抑制和感染耐受作用
Christine M Wardell,Vivian C W Fung,Eleanor Chen et al.
Christine M Wardell et al.
Regulatory T cells (Treg cells) have potential as a cell-based therapy to prevent or treat transplant rejection and autoimmunity. Using a human leukocyte antigen (HLA)-A2-specific chimeric antigen receptor (A2-CAR), we previously showed tha...
An epitope vaccine derived by analyzing clinical trial samples safeguards hosts with prior exposure to S. aureus against reinfection [0.03%]
通过分析临床试验样本衍生的抗原表位疫苗可保护金黄色葡萄球菌感染康复者免受再次感染
Xiaokai Zhang,Shuang Ge,Yu Wang et al.
Xiaokai Zhang et al.
Humans, as natural carriers of Staphylococcus aureus (SA), have developed nonprotective immune imprints that can be reactivated by SA antigen vaccination and that contribute to the failure of SA vaccine trials. To test whether an epitope-fo...
Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome [0.03%]
贝扎菲布雷改善22q11.2缺失综合征模型中的线粒体功能、血脑屏障完整性和社交缺陷
Alexis M Crockett,Maria C Vélez Colόn,Hanna Kebir et al.
Alexis M Crockett et al.
Maintenance of blood-brain barrier (BBB) integrity is critical to optimal brain function, and its impairment has been linked to multiple neurological disorders. A notable feature of the BBB is its elevated mitochondrial content compared wit...
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient [0.03%]
通过玻璃化表面活性剂辅料喷雾干燥技术实现超浓度生物药物疗法
Carolyn K Jons,Alexander N Prossnitz,Noah Eckman et al.
Carolyn K Jons et al.
Biopharmaceuticals such as peptides and antibodies have become critical to health care. Despite their exceptional potency and specificity, biopharmaceuticals are prone to aggregation, which can limit efficacy. These therapies therefore ofte...
Talia M Quandelacy,Maria F Vincente-González,Maria Eugenia Grillet et al.
Talia M Quandelacy et al.
Dengue is endemic throughout the tropical areas of the Americas, but little is known about its regional dynamics. We examined seasonal and multiannual dengue trends across the Americas and possible underlying mechanisms using monthly dengue...
High binding potency overcomes the requirement of Fc effector functions for broadly reactive anti-alphavirus antibodies [0.03%]
高抗原结合力可克服广谱抗alphavirus抗体对Fc功能的需求
Victoria Callahan,Matthew S Sutton,Christina L Gardner et al.
Victoria Callahan et al.
Alphaviruses are emerging public health threats. Broadly reactive anti-alphavirus monoclonal antibodies (mAbs) have been shown to be protective in mouse models of infection. However, the antibody characteristics that promote in vivo efficac...