A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes [0.03%]
一个削弱登革病毒在人体细胞内复制的prM基因突变增强了该病毒在蚊子的肠道感染力
Allyson N X Choi,Tanamas Siriphanitchakorn,Milly M Choy et al.
Allyson N X Choi et al.
Dengue viruses (DENVs), like all viruses, evolve to perpetuate transmission of their species in their hosts. However, how DENV genetics influences dengue disease outbreaks remains poorly understood. Here, we examined isolates of the South P...
Make it a combo [0.03%]
让它成为组合的一部分
Steven G Reed,Darrick Carter
Steven G Reed
Adjuvants that combine TLR agonists and inflammatory agonists promote robust and durable vaccine responses (Bechtold et al. and Arunachalam et al.).
Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models [0.03%]
靶向铁死亡体自噬作用可抑制急性髓系白血病休眠型癌症干细胞
Clement Larrue,Sarah Mouche,Paolo Angelino et al.
Clement Larrue et al.
Acute myeloid leukemia (AML) remains a challenging hematological malignancy with poor prognosis and limited treatment options. Leukemic stem cells (LSCs) contribute to therapeutic failure, relapse, and adverse outcome. This study investigat...
Jonathan Hare,Renske Hesselink,Alexander Bongers et al.
Jonathan Hare et al.
The development, manufacture, and deployment of new vaccine technologies to combat SARS-CoV-2 enabled an unparalleled rapid response to the emerging health threat. However, the unequal global distribution of these vaccines highlighted a maj...
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70 [0.03%]
利用编码IL-12p70的mRNA实现组织特异性表达以增强SARS-CoV-2 mRNA疫苗的效果
Byron Brook,Valerie Duval,Soumik Barman et al.
Byron Brook et al.
Messenger RNA (mRNA) vaccines were pivotal in reducing severe acute respiratory syndrome 2 (SARS-CoV-2) infection burden, yet they have not demonstrated robust durability, especially in older adults. Here, we describe a molecular adjuvant c...
Human iPSC-liver organoid transplantation reduces fibrosis through immunomodulation [0.03%]
人多能干细胞来源肝器官移植通过免疫调节降低小鼠肝纤维化
Tomomi Tadokoro,Soichiro Murata,Mimoko Kato et al.
Tomomi Tadokoro et al.
Donor organ shortages for transplantation remain a serious global concern, and alternative treatment is in high demand. Fetal cells and tissues have considerable therapeutic potential as, for example, organoid technology that uses human ind...
Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age-related tauopathy and Alzheimer's disease [0.03%]
以氟化tau蛋白配体PET研究为主的第一年龄段Tau病和阿尔茨海默病中Tau与淀粉样蛋白的关系
Keith A Josephs,Nirubol Tosakulwong,Stephen D Weigand et al.
Keith A Josephs et al.
[18F]-Flortaucipir positron emission tomography (PET) is considered a good biomarker of Alzheimer's disease. However, it is unknown how flortaucipir is associated with the distribution of tau across brain regions and how these associations ...
Primary cilia mediate skeletogenic BMP and Hedgehog signaling in heterotopic ossification [0.03%]
主异位骨化中，初级纤毛介导成骨素BMP和Hedgehog信号通路的作用
Kai He,Heng Jiang,Weijun Li et al.
Kai He et al.
Heterotopic ossification (HO), defined as the formation of extraskeletal bone in muscle and soft tissues, is a diverse pathological process caused by either genetic mutations or inciting trauma. Fibrodysplasia ossificans progressiva (FOP) i...
Extracellular vesicle-packaged PIAT from cancer-associated fibroblasts drives neural remodeling by mediating m5C modification in pancreatic cancer mouse models [0.03%]
癌相关成纤维细胞分泌的PIAT包裹于外泌体中调控胰腺导管癌小鼠模型中神经重塑及m5C修饰
Shangyou Zheng,Chonghui Hu,Qing Lin et al.
Shangyou Zheng et al.
Perineural invasion (PNI) is a biological characteristic commonly observed in pancreatic cancer. Although PNI plays a key role in pancreatic cancer metastasis, recurrence, and poor postoperative survival, its mechanism is largely unclarifie...