Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity [0.03%]
具有强体外和体内抗菌活性的半合成胍基脂糖肽抗生素
Emma van Groesen,Elma Mons,Ioli Kotsogianni et al.
Emma van Groesen et al.
Gram-positive bacterial infections present a major clinical challenge, with methicillin- and vancomycin-resistant strains continuing to be a cause for concern. In recent years, semisynthetic vancomycin derivatives have been developed to ove...
In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis [0.03%]
体内抑制布儒顿酪氨酸激酶通过调节CD84介导的粒细胞生成来缓解酒精相关性肝病
Prashanth Thevkar Nagesh,Yeonhee Cho,Yuan Zhuang et al.
Prashanth Thevkar Nagesh et al.
Severe alcohol-associated hepatitis (AH) is a life-threatening form of alcohol-associated liver disease. Liver neutrophil infiltration is a hallmark of AH, yet the effects of alcohol on neutrophil functions remain elusive. Identifying thera...
Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice [0.03%]
ピプラチニンによるaminoglycoside誘発性TRPV1活性の軽減とマウスでの難聴保護作用
Marisa Zallocchi,Sarath Vijayakumar,Jonathan Fleegel et al.
Marisa Zallocchi et al.
Hearing loss is a major health concern in our society, affecting more than 400 million people worldwide. Among the causes, aminoglycoside therapy can result in permanent hearing loss in 40% to 60% of patients receiving treatment, and despit...
A self-amplifying RNA vaccine prevents enterovirus D68 infection and disease in preclinical models [0.03%]
一种自我增殖的RNA疫苗能够预防小鼠模型中的肠病毒D68感染和致病
Nikole L Warner,Jacob Archer,Stephanie Park et al.
Nikole L Warner et al.
The recent emergence and rapid response to severe acute respiratory syndrome coronavirus 2 was enabled by prototype pathogen and vaccine platform approaches, driven by the preemptive application of RNA vaccine technology to the related Midd...
A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates [0.03%]
一种针对疟疾疫苗R21在非人灵长类动物体内的多种临床阶段佐剂的免疫学评估方法
Prabhu S Arunachalam,NaYoung Ha,S Moses Dennison et al.
Prabhu S Arunachalam et al.
Authorization of the Matrix-M (MM)-adjuvanted R21 vaccine by three countries and its subsequent endorsement by the World Health Organization for malaria prevention in children are a milestone in the fight against malaria. Yet, our understan...
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients [0.03%]
超松弛肌球蛋白有助于机械通气患者的呼吸肌冬眠现象
Marloes van den Berg,Zhonghua Shi,Wout J Claassen et al.
Marloes van den Berg et al.
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop contractile weakness of the diaphragm. Consequently, they may experience difficulty weaning from mechanical ventilation, which increases mortality...
Functional and epigenetic changes in monocytes from adults immunized with an AS01-adjuvanted vaccine [0.03%]
AS01佐剂疫苗免疫成人单核细胞的功能和表观遗传学变化
Viviane Bechtold,Kinga K Smolen,Wivine Burny et al.
Viviane Bechtold et al.
The adjuvant AS01 plays a key role in the immunogenicity of several approved human vaccines with demonstrated high efficacy. Its adjuvant effect relies on activation of the innate immune system. However, specific effects of AS01-adjuvanted ...
Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma [0.03%]
放疗患者的功能预后与神经受损图谱相关性研究
Shajedul Islam,Frederico O Gleber-Netto,Collin F Mulcahy et al.
Shajedul Islam et al.
The incidence of human papilloma virus-mediated oropharyngeal squamous cell carcinoma (OPSCC) has increased over the past 40 years, particularly among young individuals with a favorable prognosis; however, current therapy often leads to unf...
MGA deletion leads to Richter's transformation by modulating mitochondrial OXPHOS [0.03%]
MGA缺失通过调节线粒体氧化磷酸化导致里奇TERS转化
Prajish Iyer,Bo Zhang,Tingting Liu et al.
Prajish Iyer et al.
Richter's transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. MGA (Max gene associated), a functional MYC suppressor, is mutated at 3% in CLL and 36% in RT. However, genetic models and molecula...