Stress-induced eosinophil activation contributes to postoperative morbidity and mortality after lung resection [0.03%]
术后应激诱发的嗜酸性粒细胞活化与肺癌切除后的发病率和死亡率有关
Zhongcheng Mei,May A Khalil,Yizhan Guo et al.
Zhongcheng Mei et al.
Respiratory failure occurs more frequently after thoracic surgery than abdominal surgery. Although the etiology for this complication is frequently attributed to underlying lung disease present in patients undergoing thoracic surgery, this ...
Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice [0.03%]
肠道蠕虫感染损害小鼠疫苗诱导的T细胞反应和针对SARS-CoV-2的保护作用
Pritesh Desai,Courtney E Karl,Baoling Ying et al.
Pritesh Desai et al.
Although vaccines have reduced the burden of COVID-19, their efficacy in helminth infection-endemic areas is not well characterized. We evaluated the impact of infection by Heligmosomoides polygyrus bakeri (Hpb), a murine intestinal roundwo...
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier [0.03%]
靶向转铁蛋白受体以使反义寡核苷酸跨哺乳动物血脑屏障转运
Scarlett J Barker,Mai B Thayer,Chaeyoung Kim et al.
Scarlett J Barker et al.
Antisense oligonucleotides (ASOs) are promising therapeutics for treating various neurological disorders. However, ASOs are unable to readily cross the mammalian blood-brain barrier (BBB) and therefore need to be delivered intrathecally to ...
Álvaro Quintanal-Villalonga
Álvaro Quintanal-Villalonga
Omic analysis of clinical specimens undergoing histological transformation defines targetable drivers to prevent plasticity and treatment resistance.
Development and preclinical validation of 2-deoxy 2-[18F]fluorocellobiose as an Aspergillus-specific PET tracer [0.03%]
2-脱氧-2-[18F]氟半乳糖苷作为曲霉属特异性正电子发射断层扫描示踪剂的开发和临床前验证
Swati Shah,Jianhao Lai,Falguni Basuli et al.
Swati Shah et al.
The global incidence of invasive fungal infections (IFIs) has increased over the past few decades, mainly in immunocompromised patients, and is associated with high mortality and morbidity. Aspergillus fumigatus is one of the most common an...
Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice [0.03%]
自然杀伤细胞促进小鼠中性粒细胞胞外陷阱的形成并抑制小鼠年龄相关黄斑变氏病的发展
Xue Dong,Yinting Song,Yuming Liu et al.
Xue Dong et al.
Neovascular age-related macular degeneration (nvAMD) is the leading cause of blindness in the elderly population. Although it is known that nvAMD is associated with focal inflammation, understanding of the precise immune components governin...
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model [0.03%]
驱动压指导的机械通气优化了羊模型局部肺力学
David Lagier,Congli Zeng,David W Kaczka et al.
David Lagier et al.
Mechanical ventilation exposes the lung to injurious stresses and strains that can negatively affect clinical outcomes in acute respiratory distress syndrome or cause pulmonary complications after general anesthesia. Excess global lung stra...
Hui Chen,Stéphanie Moriceau,Adrien Joseph et al.
Hui Chen et al.
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a nonconventional, autophagy-dependent fashion. Here, we show that low AC...
Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas-based epigenome editing in Alzheimer's disease [0.03%]
一种工程化外泌体的光诱导蛋白递送系统能基于CRISPR-Cas对阿尔茨海默病表观基因组进行编辑
Jihoon Han,Jae Hoon Sul,Jeongmi Lee et al.
Jihoon Han et al.
Effective intracellular delivery of therapeutic proteins can potentially treat a wide array of diseases. However, efficient delivery of functional proteins across the cell membrane remains challenging. Exosomes are nanosized vesicles natura...