Inhibition of CCL7 improves endothelial dysfunction and vasculopathy in mouse models of diabetes mellitus [0.03%]
CCL7抑制改善糖尿病小鼠模型的内皮功能障碍和血管病变
Ting-Ting Chang,You-Zhen Li,Hsiao-Wei Mo et al.
Ting-Ting Chang et al.
Diabetic vascular disease is a major complication of diabetes mellitus (DM). Chemokine C-C motif ligand 7 (CCL7) attracts macrophages and monocytes, amplifying inflammatory processes in the vasculature. We hypothesized a causal role for CCL...
Activation and antitumor immunity of CD8+ T cells are supported by the glucose transporter GLUT10 and disrupted by lactic acid [0.03%]
葡萄糖转运蛋白GLUT10支持CD8⁺T细胞的活化和抗肿瘤免疫作用，乳酸可破坏其作用机制
Ying Liu,Feng Wang,Dongxue Peng et al.
Ying Liu et al.
CD8+ T cell activation leads to the rapid proliferation and differentiation of effector T cells (Teffs), which mediate antitumor immunity. Although aerobic glycolysis is preferentially activated in CD8+ Teffs, the mechanisms that regulate C...
Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration [0.03%]
抑制内皮细胞Rhoj阻断血管套叠的促纤维化和血管内分泌因子以维持肺再生
Jie Ma,Liyin Zhang,Xu Zhang et al.
Jie Ma et al.
Lung regeneration after fibrosis requires formation of functional new vasculature, which is essential for gas exchange and cellular cross-talk with other lung cells. It remains unknown how the lung vasculature can be regenerated without fib...
Joshua D Bernstock,Jakob V E Gerstl,Pablo A Valdés et al.
Joshua D Bernstock et al.
Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).
An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction [0.03%]
自身免疫转录环路导致FOXP3+调节性T细胞功能障碍
Tomokazu S Sumida,Matthew R Lincoln,Liang He et al.
Tomokazu S Sumida et al.
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4+FOXP3+ regulatory T cells (Tregs) play a central role in preventing autoimmunity, the molecular mechanism ...
Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer [0.03%]
纳米颗粒递送先天免疫激动剂联合衰老诱导剂促进T细胞控制胰腺癌
Loretah Chibaya,Kelly D DeMarco,Christina F Lusi et al.
Loretah Chibaya et al.
Pancreatic ductal adenocarcinoma (PDAC) has quickly risen to become the third leading cause of cancer-related death in the United States. This is in part because of its fibrotic tumor microenvironment (TME) that contributes to poor vascular...
Repeated Omicron exposures redirect SARS-CoV-2-specific memory B cell evolution toward the latest variants [0.03%]
重复感染奥密克戎使记忆B细胞的演变朝向最新变异体发展
Ryutaro Kotaki,Saya Moriyama,Shintaro Oishi et al.
Ryutaro Kotaki et al.
Immunological imprinting by ancestral SARS-CoV-2 strains is thought to impede the robust induction of Omicron-specific humoral responses by Omicron-based booster vaccines. Here, we analyzed the specificity and neutralization activity of mem...
Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease [0.03%]
小胶质细胞特异性递送IL-10基因抑制帕金森病鼠模型中的神经炎症和神经退行性变
Simone Bido,Melania Nannoni,Sharon Muggeo et al.
Simone Bido et al.
Neuroinflammation plays a key role in exacerbating dopaminergic neuron (DAN) loss in Parkinson's disease (PD). However, it remains unresolved how to effectively normalize this immune response given the complex interplay between the innate a...
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies [0.03%]
经修饰的C型利钠肽可重塑肿瘤血管、增强抗肿瘤免疫并改善实体瘤治疗效果
Zhen Lu,Ioannis Verginadis,Motofumi Kumazoe et al.
Zhen Lu et al.
Deficit of oxygen and nutrients in the tumor microenvironment (TME) triggers abnormal angiogenesis that produces dysfunctional and leaky blood vessels, which fail to adequately perfuse tumor tissues. Resulting hypoxia, exacerbation of metab...