HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis [0.03%]
HIF-2α诱导非酒精性steatohepatitis肝内枯氏细胞死亡和促炎单核细胞招募激活作用研究
Ishtiaq Jeelani,Jae-Su Moon,Flavia Franco da Cunha et al.
Ishtiaq Jeelani et al.
Proinflammatory hepatic macrophage activation plays a key role in the development of nonalcoholic steatohepatitis (NASH). This involves increased embryonic hepatic Kupffer cell (KC) death, facilitating the replacement of KCs with bone marro...
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging [0.03%]
靶向部分重编程年龄相关细胞状态可改善衰老小鼠模型的健康指标
Sanjeeb Kumar Sahu,Pradeep Reddy,Jinlong Lu et al.
Sanjeeb Kumar Sahu et al.
Aging is a complex multifactorial process associated with epigenome dysregulation, increased cellular senescence, and decreased rejuvenation capacity. Short-term cyclic expression of octamer-binding transcription factor 4 (Oct4), sex-determ...
A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories [0.03%]
空间解析的单细胞肺图谱与临床和血液标志物整合可区分COVID-19疾病的轨迹
João Da Silva Filho,Vanessa Herder,Matthew P Gibbins et al.
João Da Silva Filho et al.
COVID-19 is characterized by a broad range of symptoms and disease trajectories. Understanding the correlation between clinical biomarkers and lung pathology during acute COVID-19 is necessary to understand its diverse pathogenesis and info...
Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models [0.03%]
Rocuronium特异性抗体驱动术中过敏反应但也可以作为临床前模型的逆转剂
Alice Dejoux,Qianqian Zhu,Christelle Ganneau et al.
Alice Dejoux et al.
Neuromuscular blocking agents (NMBAs) relax skeletal muscles to facilitate surgeries and ease intubation but can lead to adverse reactions, including complications because of postoperative residual neuromuscular blockade (rNMB) and, in rare...
BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML [0.03%]
BATF是NK细胞在急性髓系白血病中表观遗传重编和功能障碍的主要驱动因素
Bijender Kumar,Anand Singh,Rafet Basar et al.
Bijender Kumar et al.
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from p...
Anjali Singh,César Boggiano,Dwight E Yin et al.
Anjali Singh et al.
Elucidating optimal vaccine adjuvants for harnessing age-specific immune pathways to enhance magnitude, breadth, and durability of immunogenicity remains a key gap area in pediatric vaccine design. A better understanding of age-specific adj...
Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months [0.03%]
与解决问题能力和抑郁症状结果相关的自适应认知控制环路随时间变化（为期24个月）
Xue Zhang,Adam Pines,Patrick Stetz et al.
Xue Zhang et al.
Mechanistically targeted behavioral interventions are a much-needed strategy for improving outcomes in depression, especially for vulnerable populations with comorbidities such as obesity. Such interventions may change behavior and outcome ...
A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise [0.03%]
一种皮肤可穿戴微流控平台，在人体运动时实现汗液生化指标的动态分析
Soongwon Cho,Samy M Shaban,Ruihao Song et al.
Soongwon Cho et al.
Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve simi...
PTPRT loss enhances anti-PD-1 therapy efficacy by regulation of STING pathway in non-small cell lung cancer [0.03%]
PTPRT丢失通过调节非小细胞肺癌中的STING途径增强抗PD-1治疗效果
Zhuo Chen,Wenxiang Ji,Wenxin Feng et al.
Zhuo Chen et al.
With the revolutionary progress of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, identifying patients with cancer who would benefit from ICIs has become critical and urgent. Here, we report protein tyrosine phosphatase ...