Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test [0.03%]
中性粒细胞胞外陷阱保护肾脏免遭上行感染并可产生阳性尿液白细胞检查结果
Andrew P Stewart,Kevin W Loudon,Matthew Routledge et al.
Andrew P Stewart et al.
Lower urinary tract infection (UTI) is common but only rarely complicated by pyelonephritis. However, the mechanisms preventing extension to the kidney are unclear. Here, we identified neutrophil extracellular traps (NETs) in healthy human ...
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose [0.03%]
血红素硫醇酯单加氧酶CYP1B1的抑制通过积累海藻糖防止肝星状细胞活化和肝纤维化
Hung-Chun Tung,Jong-Won Kim,Junjie Zhu et al.
Hung-Chun Tung et al.
Activation of extracellular matrix-producing hepatic stellate cells (HSCs) is a key event in liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase cytochrome P450 1B1 (CYP1B1) was elevated in human and mouse f...
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models [0.03%]
spermidine代谢通过KAT7表达调节患者衍生小鼠模型中的白血病干细胞和祖细胞功能
Vincent Rondeau,Jacob M Berman,Tianyi Ling et al.
Vincent Rondeau et al.
Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease relapse, making the development of new therapeutic strategi...
Dayan J Li,Charlotte E Berry,Derrick C Wan et al.
Dayan J Li et al.
When dysregulated, skin fibrosis can lead to a multitude of pathologies. We provide a framework for understanding the wide clinical spectrum, mechanisms, and management of cutaneous fibrosis encompassing a variety of matrix disorders, fibro...
Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade [0.03%]
肿瘤内放射剂量异质性增强小鼠的抗肿瘤免疫并引发检查点阻断反应
Justin C Jagodinsky,Jessica M Vera,Won Jong Jin et al.
Justin C Jagodinsky et al.
Radiation therapy (RT) activates multiple immunologic effects in the tumor microenvironment (TME), with diverse dose-response relationships observed. We hypothesized that, in contrast with homogeneous RT, a heterogeneous RT dose would simul...
Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis [0.03%]
深度体液谱分析结合解释性机器学习发现并解析血吸虫病诊断标志物及发病机制
Anushka Saha,Trirupa Chakraborty,Javad Rahimikollu et al.
Anushka Saha et al.
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people worldwide. Current diagnostics based on parasite egg detection in stool detect infection only at a late stage, and current antibody-based tests cann...
Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection [0.03%]
preschool年龄儿童SARS-CoV-2感染后的特异性记忆CD4+T细胞和记忆B细胞反应依旧保持较高水平
Benoît Manfroi,Bui Thi Cuc,Aurélien Sokal et al.
Benoît Manfroi et al.
The development of the human immune system lasts for several years after birth. The impact of this maturation phase on the quality of adaptive immunity and the acquisition of immunological memory after infection at a young age remains incom...
A deep intronic splice-altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion [0.03%]
一种深层内含子剪接改变型AIRE变异通过反义寡核苷酸可靶向假外显子纳入引起自身免疫 polyendocrinopathy-candidiasis-ectodermal dystrophy综合征
Sebastian Ochoa,Amy P Hsu,Andrew J Oler et al.
Sebastian Ochoa et al.
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a life-threatening monogenic autoimmune disorder primarily caused by biallelic deleterious variants in the autoimmune regulator (AIRE) gene. We prospectively evaluat...
ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome [0.03%]
一种作用于人MuSK的激动型抗体ARGX-119可逆转先天性肌无力综合征小鼠模型的疾病加重现象
Roeland Vanhauwaert,Julien Oury,Bernhardt Vankerckhoven et al.
Roeland Vanhauwaert et al.
Muscle-specific kinase (MuSK) is essential for the formation, function, and preservation of neuromuscular synapses. Activation of MuSK by a MuSK agonist antibody may stabilize or improve the function of the neuromuscular junction (NMJ) in p...
Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans [0.03%]
急性脊髓损伤后的灌注影像学指标与大鼠和人类的损伤严重程度相关
Zin Z Khaing,Jannik Leyendecker,Jennifer N Harmon et al.
Zin Z Khaing et al.
Traumatic spinal cord injury (tSCI) causes an immediate loss of neurological function, and the prediction of recovery is difficult in the acute phase. In this study, we used contrast-enhanced ultrasound imaging to quantify intraspinal vascu...