Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes [0.03%]
线粒体肌酸激酶2减少以葡萄糖为燃料的骨骼肌线粒体功能独立于胰岛素在2型糖尿病中的作用
David Rizo-Roca,Dimitrius Santiago P S F Guimarães,Logan A Pendergrast et al.
David Rizo-Roca et al.
Increased plasma creatine concentrations are associated with the risk of type 2 diabetes, but whether this alteration is associated with or causal for impairments in metabolism remains unexplored. Because skeletal muscle is the main disposa...
A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo [0.03%]
一种针对SARS-CoV-2的多特异抗体可在体外预防免疫逃逸并在体内提供保护作用
John Misasi,Ronnie R Wei,Lingshu Wang et al.
John Misasi et al.
Despite effective countermeasures, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists worldwide because of its ability to diversify and evade human immunity. This evasion stems from amino acid substitutions, particularly ...
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis [0.03%]
一个促炎性干细胞生态位通过可靶向的岩藻糖结合凝集素-1轴驱动骨髓纤维化
Rong Li,Michela Colombo,Guanlin Wang et al.
Rong Li et al.
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukemi...
Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury [0.03%]
糖皮质激素通过诱发适应不良的上皮细胞应激反应来加重急性肾损伤
Luping Zhou,Marc Torres Pereiro,Yanqun Li et al.
Luping Zhou et al.
Acute kidney injury (AKI) is a frequent and challenging clinical condition associated with high morbidity and mortality and represents a common complication in critically ill patients with COVID-19. In AKI, renal tubular epithelial cells (T...
A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice [0.03%]
由MYC的上游开放阅读框编码的肽与盘状受体酪氨酸蛋白激酶B结合并促进小鼠胶质母细胞瘤的生长
Fanying Li,Kailin Yang,Xinya Gao et al.
Fanying Li et al.
MYC promotes tumor growth through multiple mechanisms. Here, we show that, in human glioblastomas, the variant MYC transcript encodes a 114-amino acid peptide, MYC pre-mRNA encoded protein (MPEP), from the upstream open reading frame (uORF)...
LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease [0.03%]
LRRK2调节帕金森病细胞和动物模型中活性氧的产生
Matthew T Keeney,Emily M Rocha,Eric K Hoffman et al.
Matthew T Keeney et al.
Oxidative stress has long been implicated in Parkinson's disease (PD) pathogenesis, although the sources and regulation of reactive oxygen species (ROS) production are poorly defined. Pathogenic mutations in the gene encoding leucine-rich r...
A microbiome-directed therapeutic food for children recovering from severe acute malnutrition [0.03%]
用于重度急性营养不良患儿恢复期的微生态导向辅助食品
Steven J Hartman,Matthew C Hibberd,Ishita Mostafa et al.
Steven J Hartman et al.
Globally, severe acute malnutrition (SAM), defined as a weight-for-length z-score more than three SDs below a reference mean (WLZ < -3), affects 14 million children under 5 years of age. Complete anthropometric recovery after standard, shor...
Randomized Controlled Trial
Science translational medicine. 2024 Oct 2;16(767):eadn2366. DOI:10.1126/scitranslmed.adn2366 2024
Dynamic structural remodeling of LINC01956 enhances temozolomide resistance in MGMT-methylated glioblastoma [0.03%]
动态结构重塑LINC01956增强MGMT甲基化胶质母细胞瘤的替莫唑胺耐药性
Xinyi Liao,Shuxia Zhang,Xincheng Li et al.
Xinyi Liao et al.
The mechanisms underlying stimuli-induced dynamic structural remodeling of RNAs for the maintenance of cellular physiological function and survival remain unclear. Here, we showed that in MGMT promoter-methylated glioblastoma (GBM), the RNA...
Reduction of prolonged excitatory neuron swelling after spinal cord injury improves locomotor recovery in mice [0.03%]
脊髓损伤后延长的兴奋性神经元肿胀消退可改善小鼠运动恢复能力
Qiang Li,Alfredo Sandoval,John Moth et al.
Qiang Li et al.
Spinal cord injury (SCI) results in acute damage and triggers secondary injury responses with sustained neuronal loss and dysfunction. However, the underlying mechanisms for these delayed neuronal pathologies are not entirely understood. SC...
B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling [0.03%]
B细胞通过IgG-Fcγ受体信号转导在小鼠神经病理性疼痛相关行为中发挥驱动作用
Michael J Lacagnina,Kendal F Willcox,Nabila Boukelmoune et al.
Michael J Lacagnina et al.
Neuroimmune interactions are essential for the development of neuropathic pain, yet the contributions of distinct immune cell populations have not been fully unraveled. Here, we demonstrate the critical role of B cells in promoting mechanic...