Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa [0.03%]
重复的基于mRNA的COVID-19疫苗接种有助于黏膜中新冠病毒中和抗体的产生
Jozefien Declercq,Sarah Gerlo,Sharon Van Nevel et al.
Jozefien Declercq et al.
To prevent infection by respiratory viruses and consequently limit virus circulation, vaccines need to promote mucosal immunity. The extent to which the currently used messenger RNA (mRNA)-based COVID-19 vaccines induce mucosal immunity rem...
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy [0.03%]
隐孢子虫赖氨酰tRNA合成酶抑制剂定义了溶解性和渗透性之间的作用关系以达到有效性
Nicola Caldwell,Caroline Peet,Peter Miller et al.
Nicola Caldwell et al.
Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp. parasites and is a leading cause of death in malnourished children worldwide. The only approved treatment, nitazoxanide, has limited efficacy in this at-...
Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy [0.03%]
基质重编程克服RAS-MAPK通路抑制的耐药性以增强胰腺癌对细胞毒和免疫疗法的反应
Xiuting Liu,John M Baer,Meredith L Stone et al.
Xiuting Liu et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is often resistant to therapy. An immune suppressive tumor microenvironment (TME) and oncogenic mutations in KRAS have both been implicated as drivers of resistance to ther...
Follistatin drives neuropathic pain in mice through IGF1R signaling in nociceptive neurons [0.03%]
Follistatin通过痛觉神经元中的IGF1R信号转导驱动小鼠的神经病理性疼痛
Bao-Chun Jiang,Yue-Juan Ling,Meng-Lin Xu et al.
Bao-Chun Jiang et al.
Neuropathic pain is a debilitating chronic condition that lacks effective treatment. The role of cytokine- and chemokine-mediated neuroinflammation in its pathogenesis has been well documented. Follistatin (FST) is a secreted protein known ...
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease [0.03%]
高保真的PAMless碱基编辑造血干细胞以治疗慢性肉芽肿病
Vera Bzhilyanskaya,Linyuan Ma,Siyuan Liu et al.
Vera Bzhilyanskaya et al.
X-linked chronic granulomatous disease (X-CGD) is an inborn error of immunity (IEI) resulting from genetic mutations in the cytochrome b-245 beta chain (CYBB) gene. The applicability of base editors (BEs) to correct mutations that cause X-C...
Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis [0.03%]
褪黑素受体1A变异与原发性骨质疏松的关系研究
Brygida Bisikirska,Rossella Labella,Alvaro Cuesta-Dominguez et al.
Brygida Bisikirska et al.
Idiopathic osteoporosis (IOP) is a rare form of early-onset osteoporosis diagnosed in patients with no known metabolic or hormonal cause of bone loss and unknown pathogenesis. Patients with IOP commonly report both childhood fractures and f...
Intraoperative evaluation of tumor margins using a TROP2 near-infrared imaging probe to enable human breast-conserving surgery [0.03%]
用于乳腺肿瘤保留手术术中评估肿瘤边缘的TROP2近红外成像探针研究
Weiling Chen,Yongqu Zhang,Lixin Zhang et al.
Weiling Chen et al.
Intraoperative surgical margin assessment remains a challenge during breast-conserving surgery. Here, we report a combined strategy of immuno-positron emission tomography (PET) for preoperative detection of breast cancer and guided assessme...
Human OX40L-CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity [0.03%]
人源OX40L-CARTregs针对活化的抗原呈递细胞并控制T细胞的同种异体反应性
Xianliang Rui,Francesca Alvarez Calderon,Holly Wobma et al.
Xianliang Rui et al.
Regulatory T cells (Tregs) make major contributions to immune homeostasis. Because Treg dysfunction can lead to both allo- and autoimmunity, there is interest in correcting these disorders through Treg adoptive transfer. Two of the central ...
An altered natural killer cell immunophenotype characterizes clinically severe pediatric RSV infection [0.03%]
儿童严重RSV感染的自然杀伤细胞免疫表型异常
Roisin B Reilly,Saïsha K Ramdour,Mary E Fuhlbrigge et al.
Roisin B Reilly et al.
Respiratory syncytial virus (RSV) infects nearly all children by 2 years of age and is a leading cause of pediatric hospitalizations. A subset of children with RSV infection (RSV+ children) develop respiratory failure requiring intensive ca...
Sleep-sensitive dopamine receptor expression in male mice underlies attention deficits after a critical period of early adversity [0.03%]
雄性小鼠关键早期应激后注意缺陷与多巴胺受体表达及睡眠异常有关
Yuichi Makino,Nathaniel W Hodgson,Emma Doenier et al.
Yuichi Makino et al.
Early life stress (ELS) yields cognitive impairments of unknown molecular and physiological origin. We found that fragmented maternal care of mice during a neonatal critical period from postnatal days P2-9 elevated dopamine receptor D2R and...