Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice [0.03%]
小清蛋白受体神经元-巨噬细胞相互作用驱动小鼠子宫内膜异位症疼痛和病灶生长
Victor Fattori,Tiago H Zaninelli,Fernanda S Rasquel-Oliveira et al.
Victor Fattori et al.
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women and transgender men. Current treatments are ineffective for a substantial proportion of patients, underscoring the need for addition...
A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy [0.03%]
一种肾脏特异性的间歇性断食模拟饮食诱导系膜细胞重编以修复肾小球病患者的肾脏功能损伤
Valentina Villani,Camille Nicolas Frank,Paolo Cravedi et al.
Valentina Villani et al.
Cycles of a fasting-mimicking diet (FMD) promote regeneration and reduce damage in the pancreases, blood, guts, and nervous systems of mice, but their effect on kidney disease is unknown. In addition, a FMD has not been tested in rats. Here...
Emily P English,Rachel N Swingler,Simran Patwa et al.
Emily P English et al.
Chimeric antigen receptor-T cell (CAR-T) therapy has transformed the management of refractory hematological malignancies. Now that targeting pathogenic cells of interest with antigen-directed cytotoxic T lymphocytes is possible, the field i...
Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains [0.03%]
帕金森病脑的单细胞转录组和蛋白质组分析
Biqing Zhu,Jae-Min Park,Sarah R Coffey et al.
Biqing Zhu et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are largely unknown. To ...
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted [0.03%]
肿瘤性脂滴负载的巨噬细胞在人类胶质母细胞瘤中富集并可以被靶向治疗
Valeria Governa,Kelin Gonçalves de Oliveira,Anna Bång-Rudenstam et al.
Valeria Governa et al.
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive an...
Inhibition of an Alzheimer's disease-associated form of necroptosis rescues neuronal death in mouse models [0.03%]
抑制与阿尔茨海默病相关的坏死性凋亡形式可挽救小鼠模型中的神经元死亡
Marta J Koper,Sebastiaan Moonen,Alicja Ronisz et al.
Marta J Koper et al.
Necroptosis is a regulated form of cell death that has been observed in Alzheimer's disease (AD) along with the classical pathological hallmark lesions of amyloid plaques and Tau neurofibrillary tangles. To understand the neurodegenerative ...
Bayesian modeling for analyzing heterogeneous response in preclinical mouse tumor models [0.03%]
用于分析临床前小鼠肿瘤模型中异质性反应的贝叶斯建模方法研究
Bairu Zhang,Lukasz Magiera,Juliana Candido et al.
Bairu Zhang et al.
In anticancer research, tumor growth measured in mouse models is important for assessing treatment efficacy for a treatment to progress to human clinical trials. Statistical analysis of time-to-event tumor volume data is complex because of ...
Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation [0.03%]
造血干细胞移植后几十年供体-受者对中克隆动态的双联测序特征分析
Masumi Ueda Oshima,Jacob Higgins,Isaac Jenkins et al.
Masumi Ueda Oshima et al.
After allogeneic hematopoietic cell transplantation (HCT), a very small number of donor stem cells reconstitute the recipient hematopoietic system, whereas the donor is left with a near-normal pool of stem cells. We hypothesized that the in...
From blood to mucosa [0.03%]
从血液到黏膜
Jinyi Tang,Jie Sun
Jinyi Tang
Current COVID-19 vaccines induce suboptimal respiratory mucosal immunity even after mRNA boosters (Declercq et al. and Lasrado et al., this issue).
SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity [0.03%]
SARS-CoV-2 XBB.1.5 mRNA加强针疫苗诱导有限的粘膜免疫反应
Ninaad Lasrado,Marjorie Rowe,Katherine McMahan et al.
Ninaad Lasrado et al.
Current COVID-19 vaccines provide robust protection against severe disease but minimal protection against acquisition of infection. Intramuscularly administered COVID-19 vaccines induce robust serum neutralizing antibodies (NAbs), but their...