Julio Silva,Akiko Iwasaki
Julio Silva
Postacute infection syndromes like Long Covid disproportionately affect females, differing in prevalence, symptoms, and potential causes from males. This Viewpoint highlights these sex differences, gaps in current understanding, and the cri...
Adriana Marques
Adriana Marques
Protracted fatigue and other symptoms can occur after Lyme disease and other infections, with numerous possible drivers. Studies on posttreatment Lyme disease have been inconclusive, with no confirmed biomarker emerging. Prolonged antibioti...
Alexandra Schäfer,Sarah R Leist,John M Powers et al.
Alexandra Schäfer et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health co...
Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution [0.03%]
长新冠的性别差异及免疫学特征：症状持续与缓解因素分析
Rebecca E Hamlin,Shaun M Pienkos,Leslie Chan et al.
Rebecca E Hamlin et al.
Sex differences have been observed in acute coronavirus disease 2019 (COVID-19) and Long Covid (LC) outcomes, with greater disease severity and mortality during acute infection in males and greater proportions of females developing LC. We h...
Annukka A R Antar,Andrea L Cox
Annukka A R Antar
Long Covid is defined by a wide range of symptoms that persist after the acute phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported symptoms include fatigue, weakness, postexertional malaise, an...
Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population [0.03%]
整合多组学分析鉴定出中国人群非酒精性脂肪肝的独特分子亚型
Jingjing Ding,Huaizheng Liu,Xiaoxun Zhang et al.
Jingjing Ding et al.
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes of clinical diagnosis and pharmacotherapy. Several NAFLD classifications have be...
Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients [0.03%]
斑马素-II神经元亚型在小鼠和患者的多聚谷氨酰胺共核苷酸扩增引起的脊髓小脑性共济失调中的调控异常
Luke C Bartelt,Pawel M Switonski,Grażyna Adamek et al.
Luke C Bartelt et al.
Spinocerebellar ataxia type 7 (SCA7) is a genetic neurodegenerative disorder caused by a CAG-polyglutamine repeat expansion. Purkinje cells (PCs) are central to the pathology of ataxias, but their low abundance in the cerebellum underrepres...
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19 [0.03%]
与COVID-19恢复相关的气道中瞬时的抗干扰素自身抗体
Benjamin R Babcock,Astrid Kosters,Devon J Eddins et al.
Benjamin R Babcock et al.
Preexisting anti-interferon-α (anti-IFN-α) autoantibodies in blood are associated with susceptibility to life-threatening COVID-19. However, it is unclear whether anti-IFN-α autoantibodies in the airways, the initial site of infection, c...
The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice [0.03%]
R1441C-Lrrk2突变以年龄和性别依赖的方式诱导小鼠髓系免疫细胞衰竭
Rebecca L Wallings,Karen McFarland,Hannah A Staley et al.
Rebecca L Wallings et al.
Age is the greatest risk factor for many neurodegenerative diseases, yet immune system aging, a contributor to neurodegeneration, is understudied. Genetic variation in the LRRK2 gene affects risk for both familial and sporadic Parkinson's d...
Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infection [0.03%]
针对刺突蛋白的单克隆抗体可改变对新冠病毒疫苗接种和感染的内源性体液免疫反应
Christopher D Petro,Andrea T Hooper,Avery Peace et al.
Christopher D Petro et al.
Increased use of antiviral monoclonal antibodies (mAbs) for treatment and prophylaxis necessitates better understanding of their impact on endogenous immunity to vaccines and viruses. The severe acute respiratory syndrome coronavirus 2 (SAR...