Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration [0.03%]
番石榴素能挽救先天性自主神经缺陷模型的发育和退行性缺陷并加速轴突再生
Kenyi Saito-Diaz,Paula Dietrich,Tripti Saini et al.
Kenyi Saito-Diaz et al.
The peripheral nervous system (PNS) is essential for proper body function. A high percentage of the world's population suffers from nerve degeneration or peripheral nerve damage. Despite this, there are major gaps in the knowledge of human ...
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells [0.03%]
单克隆抗体通过阻断圆柱素1和2信号来靶向病理性的视网膜新生血管化作用于髓系细胞中
Luiz Henrique Geraldo,Yunling Xu,Gaspard Mouthon et al.
Luiz Henrique Geraldo et al.
Roundabout (ROBO) 1 and 2 are transmembrane receptors that bind secreted SLIT ligands through their extracellular domains (ECDs) and signal through their cytoplasmic domains to modulate the cytoskeleton and regulate cell migration, adhesion...
NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer [0.03%]
NIT2通过抑制BRD1相分离和限制氧化磷酸化来提高胃癌的化学敏感性
Ziyang Wang,Yuqin Di,Xiangqiong Wen et al.
Ziyang Wang et al.
5-Fluorouracil (5-FU) chemoresistance contributes to poor therapeutic response and prognosis of gastric cancer (GC), for which effective strategies to overcome chemoresistance are limited. Here, using a CRISPR-Cas9 system, we identified tha...
Vagal stimulation ameliorates murine colitis by regulating SUMOylation [0.03%]
迷走神经刺激通过调节SUMO化改善小鼠结肠炎
Ayman Youssef,Ata Ur Rehman,Mohamed Elebasy et al.
Ayman Youssef et al.
Inflammatory bowel diseases (IBDs) are chronic debilitating conditions without cure, the etiologies of which are unknown, that shorten the lifespans of 7 million patients worldwide by nearly 10%. Here, we found that decreased autonomic para...
Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis [0.03%]
通过CDK7抑制干扰RNA聚合酶II转录周期可改善炎性关节炎
Xi Chen,Gayathri Shibu,Baila A Sokolsky et al.
Xi Chen et al.
Macrophages are key drivers of inflammation and tissue damage in autoimmune diseases including rheumatoid arthritis. The rate-limiting step for transcription of more than 70% of inducible genes in macrophages is RNA polymerase II (Pol II) p...
Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease [0.03%]
延迟低剂量口服给药的4'-氟尿苷可抑制致命性疾病模型中的致病性 Arenavirus病毒感染
Stephen R Welch,Jessica R Spengler,Jonna B Westover et al.
Stephen R Welch et al.
Development of broad-spectrum antiviral therapies is critical for outbreak and pandemic preparedness against emerging and reemerging viruses. Viruses inducing hemorrhagic fevers cause high morbidity and mortality in humans and are associate...
Jeanne Marrazzo,Gary H Gibbons,Walter Koroshetz
Jeanne Marrazzo
The NIH's RECOVER Initiative aims to ease the suffering of those living with Long Covid.
Sharon H Saydah,Angela P Campbell,Adrienne G Randolph
Sharon H Saydah
Although most children are spared from developing complications from SARS-CoV-2 infection, some may suffer consequences including Long Covid and multisystem inflammatory syndrome in children (MIS-C). Although the occurrence of these conditi...
Infection-associated chronic conditions: Why Long Covid is our best chance to untangle Osler's web [0.03%]
与感染相关的慢性疾病：为什么长期新冠是我们解开奥尔谢尔网的最佳机会
Michael J Peluso,Maureen R Hanson,Steven G Deeks
Michael J Peluso
The recognition of Long Covid has renewed efforts to understand other infection-associated chronic conditions (IACCs). Here, we describe how studies of Long Covid and other IACCs might inform one another. We argue for the importance of a co...