Matthew Vogel,Adam Tellier,Rena M Conti
Matthew Vogel
There is uncertainty regarding which brand-name prescription drugs will have their prices negotiated by Medicare in 2025. This Viewpoint analyzes the process that will be used to select the next 15 drugs for price negotiation.
Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells [0.03%]
儿童期狼疮性肾炎的发病特点是肾脏基质与浸润免疫细胞间的复杂相互作用
Patrick Danaher,Nicholas Hasle,Elizabeth D Nguyen et al.
Patrick Danaher et al.
Children with systemic lupus erythematosus (SLE) are at increased risk of developing kidney disease, termed childhood-onset lupus nephritis (cLN). Single-cell transcriptomics of dissociated kidney tissue has advanced our understanding of LN...
Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans [0.03%]
血管生成标志物的性别二态性差异与人类脑老化轨迹有关
Abel Torres-Espin,Hannah L Radabaugh,Scott Treiman et al.
Abel Torres-Espin et al.
Aberrant angiogenesis could contribute to the development of cognitive impairment and represent a therapeutic target for preventing dementia. However, most studies addressing angiogenesis and cognitive impairment focus on model organisms. T...
An mRNA-encoded dominant-negative inhibitor of transcription factor RUNX1 suppresses vitreoretinal disease in experimental models [0.03%]
一种针对转录因子RUNX1的编码mRNA嵌合体在实验模型中可抑制视网膜血管病变的发展
Michael O&#x;Hare,William P Miller,Said Arevalo-Alquichire et al.
Michael O&#x;Hare et al.
Messenger RNA (mRNA)-based therapies are a promising approach to medical treatment. Except for infectious diseases, no other disease has mRNA-based therapies available. The eye is an ideal model for mRNA therapeutic development because it r...
Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation [0.03%]
靶向PDE3B-cAMP-自噬轴防止长期超低温保存诱导的肝损伤
Xingyuan Jiao,Yihu Li,Zhihang Chen et al.
Xingyuan Jiao et al.
In liver transplantation, donor livers are typically stored in a preservation solution at 4°C for up to 12 hours. However, this short preservation duration can lead to various issues, such as suboptimal donor-recipient matching and limited...
Seeding-competent TDP-43 persists in human patient and mouse muscle [0.03%]
人患者和小鼠肌肉中的播种 competent tdp-43 持续存在
Eileen M Lynch,Sara Pittman,Jil Daw et al.
Eileen M Lynch et al.
TAR DNA binding protein 43 (TDP-43) is an RNA binding protein that accumulates as aggregates in the central nervous systems of some patients with neurodegenerative diseases. However, TDP-43 aggregation is also a sensitive and specific patho...
A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models [0.03%]
一种可穿戴的渗透微型针头补丁可以为动物模型提供高容量的持续药物输送
Sheng Zhao,Ziyi Lu,Ruisi Cai et al.
Sheng Zhao et al.
The maintenance of stable plasma drug concentrations within a therapeutic window can be critical for drug efficacy. Here, we developed a wearable osmotic microneedle (OMN) patch to support sustained drug dosing for at least 24 hours without...