Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation [0.03%]
谷氨酸受体GluK2的拮抗作用可抑制皮肤肥大细胞活化和皮肤病灶炎症反应
Youran R Zhang,Swapnil Keshari,Kazuo Kurihara et al.
Youran R Zhang et al.
Activation of dermal mast cells through the Mas-related G protein-coupled receptor B2 receptor (MrgprB2 in mice and MrgprX2 in humans) is a key component of numerous inflammatory skin diseases, including dermatitis and rosacea. Sensory neur...
Shadi A Esfahani,Li Ma,Shriya Krishna et al.
Shadi A Esfahani et al.
Patients with advanced gastric cancer (GCa) have limited treatment options, and alternative treatment approaches are necessary to improve their clinical outcomes. Because fibrin is abundant in gastric tumors but not in healthy tissues, we h...
Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation [0.03%]
一种上皮钠通道抑制剂的再利用可治疗小鼠和人类皮肤炎症
Mårten C G Winge,Mazen Nasrallah,Leandra V Jackrazi et al.
Mårten C G Winge et al.
Inflammatory skin disease is characterized by a pathologic interplay between skin cells and immunocytes and can result in disfiguring cutaneous lesions and systemic inflammation. Immunosuppression is commonly used to target the inflammatory...
Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity [0.03%]
增加的角质细胞活性和PIEZO1信号传导导致紫杉醇诱导的机械性超敏反应
Alexander R Mikesell,Elena Isaeva,Marie L Schulte et al.
Alexander R Mikesell et al.
Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse mode...
ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools [0.03%]
ABC转运蛋白G1通过重新构建饱和脂肪酸池在肥胖中调控脂肪组织巨噬细胞的可塑性及胰岛素抵抗现象
Veronica D Dahik,Pukar Kc,Clément Materne et al.
Veronica D Dahik et al.
The mechanisms governing adipose tissue macrophage (ATM) metabolic adaptation during diet-induced obesity (DIO) are poorly understood. In obese adipose tissue, ATMs are exposed to lipid fluxes, which can influence the activation of specific...
Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment [0.03%]
单细胞分析肢端黑素瘤浸润淋巴细胞揭示了抑制性肿瘤微环境
Tomoyuki Minowa,Kenji Murata,Yuka Mizue et al.
Tomoyuki Minowa et al.
Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune p...
RANKL treatment restores thymic function and improves T cell-mediated immune responses in aged mice [0.03%]
Rankl治疗恢复了老年小鼠胸腺功能并改善T细胞介导的免疫反应
Jérémy C Santamaria,Jessica Chevallier,Léa Dutour et al.
Jérémy C Santamaria et al.
Age-related thymic involution, leading to reduced T cell production, is one of the major causes of immunosenescence. This results in an increased susceptibility to cancers, infections, and autoimmunity and in reduced vaccine efficacy. Here,...
Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease [0.03%]
小胶质细胞和单核细胞特异性NPC1缺失小鼠模拟尼曼匹克病患者的小胶质细胞反应和神经变性
Lina Dinkel,Selina Hummel,Valerio Zenatti et al.
Lina Dinkel et al.
Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in the NPC1 gene, causing lipid accumulation within late endosomes/lysosomes and resulting in progressive neurodegeneration. Although mi...
Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist [0.03%]
GLP-1受体和瘦素受体共表达的神经元调节GLP-1/瘦素双重激动剂对摄食量和体重的抑制作用
Joseph Polex-Wolf,Kristine Deibler,Wouter Frederik Johan Hogendorf et al.
Joseph Polex-Wolf et al.
Glucagon-like peptide-1 (GLP-1) and leptin signal recent feeding and long-term energy stores, respectively, and play complementary roles in the modulation of energy balance. Previous work using single-cell techniques in mice revealed the ex...
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation [0.03%]
心脏停搏复苏后多样性的NKT细胞调控早期炎症及神经功能预后
Tomoyoshi Tamura,Changde Cheng,Ana B Villaseñor-Altamirano et al.
Tomoyoshi Tamura et al.
Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA)...