Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration [0.03%]
小鼠大脑和人类神经元培养物的脂质组学分析揭示了MBOAT7在mTOR依赖性神经元迁移中的作用
Isaac Tang,Ashna Nisal,Alex Reed et al.
Isaac Tang et al.
Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling. MBOAT7 encodes a key acyltransferase in PI synthesis and is m...
An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup [0.03%]
炎性状态界定了高危T细胞急性淋巴细胞白血病亚群
Mark Gower,Ximing Li,Alicia G Aguilar-Navarro et al.
Mark Gower et al.
T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising diverse subtypes that are challenging to stratify using conventional immunophenotyping. To gain insights into subset-specific therapeutic vulnerabilities, we pe...
IFN-γ-producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren's disease [0.03%]
产生IFN-γ的TH1细胞及功能失调的调节性T细胞参与Sjögren综合征的发病机制
Yin-Hu Wang,Wenyi Li,Maxwell McDermott et al.
Yin-Hu Wang et al.
Sjögren's disease (SjD) is an autoimmune disorder characterized by progressive salivary and lacrimal gland dysfunction, inflammation, and destruction, as well as extraglandular manifestations. SjD is associated with autoreactive B and T ce...
An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus [0.03%]
一种流感mRNA疫苗可保护易感动物模型免于高致病性H5N1禽流感病毒感染导致的致命感染
Masato Hatta,Yasuko Hatta,Angela Choi et al.
Masato Hatta et al.
The global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating the swift development of effective vaccines. The success of messenger RNA (mRNA) vaccine technology in the COVID-...
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans [0.03%]
纹状体刺激增强啮齿类和人类的认知控制和证据处理能力
Adriano E Reimer,Evan M Dastin-van Rijn,Jaejoong Kim et al.
Adriano E Reimer et al.
Brain disorders, in particular mental disorders, might be effectively treated by direct electrical brain stimulation, but clinical progress requires understanding of therapeutic mechanisms. Animal models have not helped, because there are n...
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis [0.03%]
右美沙芬通过抑制胶原和类似胶原的分泌来改善肺纤维化
Muzamil M Khan,George Galea,Juan Jung et al.
Muzamil M Khan et al.
Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our understanding of the molecular mechanisms underlying the...
Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth [0.03%]
药物筛选的颅咽管瘤模型揭示了肿瘤生长的神经机制
Si Li,Wei Li,Yuqi Miao et al.
Si Li et al.
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuroendocrine neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar ...
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron [0.03%]
Orforglipron的GLP-1受体非肽激动作用的药理学基础
Kyle W Sloop,Amy L Cox,David B Wainscott et al.
Kyle W Sloop et al.
Orally bioavailable, synthetic nonpeptide agonists (NPAs) of the glucagon-like peptide-1 receptor (GLP-1R) may offer an effective, scalable pharmacotherapy to address the metabolic disease epidemic. One of the first molecules in the emergin...
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes [0.03%]
丙二酸裂解酶通过代谢和表观遗传改变驱动全身性和肺血管疾病中的血管重塑
Yann Grobs,Charlotte Romanet,Sarah-Eve Lemay et al.
Yann Grobs et al.
ATP citrate lyase (ACLY), a crucial enzyme in de novo lipid synthesis and histone acetylation, plays a key role in regulating vascular smooth muscle cell (VSMC) proliferation and survival. We found that human coronary and pulmonary artery t...