High-frequency epidural electrical stimulation reduces spasticity and facilitates walking recovery in patients with spinal cord injury [0.03%]
高频硬膜外电刺激可降低脊髓损伤患者的肌张力并促进步行功能恢复
Simone Romeni,Elena Losanno,Daniele Emedoli et al.
Simone Romeni et al.
Spinal cord injury (SCI) causes severe motor and sensory deficits, and there are currently no approved treatments for recovery. Nearly 70% of patients with SCI experience pathological muscle cocontraction and spasticity, accompanied by clin...
Hypoxia-inducible factor 2 regulates alveolar regeneration after repetitive injury in three-dimensional cellular and in vivo models [0.03%]
缺氧诱导因子2通过三维细胞和体内模型中的重复损伤后调节肺泡再生作用
A Scott McCall,Sergey Gutor,Hari Tanjore et al.
A Scott McCall et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which repetitive epithelial injury and incomplete alveolar repair result in accumulation of profibrotic intermediate/transitional "aberrant" epithelial cell s...
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance [0.03%]
抗生素候选药物会诱发革兰氏阳性菌产生多重耐药性
Ana Martins,Fanni Judák,Zoltán Farkas et al.
Ana Martins et al.
Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not ye...
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations [0.03%]
一种工程化的免疫原能够激活多样化的HIV广谱中和抗体前体并促进获得不可能的突变
Olivia M Swanson,Qianyi E Zhang,Elizabeth Van Itallie et al.
Olivia M Swanson et al.
Elicitation of HIV broadly neutralizing antibodies (bnAbs) by vaccination first requires the activation of diverse precursors, followed by successive boosts that guide these responses to enhanced breadth through the acquisition of somatic m...
Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder [0.03%]
靶向CD74信号轴可抑制炎症并修复RUNX1家族性血小板疾病患者的缺陷造血干细胞功能
Mona Mohammadhosseini,Trevor Enright,Adam Duvall et al.
Mona Mohammadhosseini et al.
Familial platelet disorder (FPD) is associated with germline RUNX1 mutations, establishing a preleukemic state and increasing the risk of developing leukemia. Currently, there are no intervention strategies to prevent leukemia progression. ...
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination [0.03%]
蛋白激酶C调节剂 Bryostatin-1通过靶向小胶质细胞来缓解神经炎症和促进脱髓鞘再(myelin)化治疗作用研究
Payam Gharibani,Efrat Abramson,Shruthi Shanmukha et al.
Payam Gharibani et al.
In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance among demyelination, neurodegeneration, and myelin repair. Phagocytic and regenerative functions...
Glutamic-pyruvic transaminase 1 deficiency-mediated metabolic reprogramming facilitates colorectal adenoma-carcinoma progression [0.03%]
谷氨酰胺-丙酮酸转氨酶1缺乏介导的代谢重编程促进结直肠腺瘤-癌转化
Li Xiong,Xin Yang,Huashan Liu et al.
Li Xiong et al.
The tumorigenesis of colorectal cancer (CRC) often follows the normal-adenoma-carcinoma (N-A-C) sequence. However, the molecular mechanisms underlying colorectal adenoma carcinogenesis remain largely unknown. Here, we analyzed transcriptomi...
Vaccination with different group 2 influenza subtypes alters epitope targeting and breadth of hemagglutinin stem-specific human B cells [0.03%]
不同分型的2组流感疫苗接种会改变人类血凝素茎特异性B细胞靶点和广度
Grace E Mantus,Ankita J Chopde,Jason Gorman et al.
Grace E Mantus et al.
The conserved influenza hemagglutinin stem, which is a target of cross-neutralizing antibodies, is now used in vaccine strategies focused on protecting against influenza pandemics. Antibody responses to group 1 stem have been extensively ch...
G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells [0.03%]
G6PC2通过定义葡萄糖的基准值来控制胰岛α细胞的胰高血糖素分泌
Varun Bahl,Reut Rifkind,Eric Waite et al.
Varun Bahl et al.
Elevated glucagon concentrations have been reported in patients with type 2 diabetes (T2D). A critical role for α cell-intrinsic mechanisms in regulating glucagon secretion was previously established through genetic manipulation of the gly...
CD154 blockade effectively controls antibody-mediated rejection in highly sensitized nonhuman primate kidney transplant recipients [0.03%]
CD154阻断有效控制高致敏非人灵长类器官移植受者的抗体介导的排斥反应
Imran J Anwar,Isabel DeLaura,Joseph M Ladowski et al.
Imran J Anwar et al.
Current desensitization and maintenance immunosuppression regimens for kidney transplantation in sensitized individuals show limited ability to control the posttransplant humoral response, resulting in high rates of antibody-mediated reject...