Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation [0.03%]
非人灵长类心脏移植耐受性可以通过供者骨髓和肾脏联合移植实现
Makoto Tonsho,Jane M O,Kaitlan Ahrens et al.
Makoto Tonsho et al.
Long-term, immunosuppression-free allograft survival has been induced in human and nonhuman primate (NHP) kidney recipients after nonmyeloablative conditioning and donor bone marrow transplantation (DBMT), resulting in transient mixed hemat...
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease [0.03%]
淀粉样蛋白相关过度连接驱动阿尔茨海默病中tau在相连脑区的传播
Sebastian N Roemer-Cassiano,Fabian Wagner,Lisa Evangelista et al.
Sebastian N Roemer-Cassiano et al.
In Alzheimer's disease (AD), amyloid-β (Aβ) triggers the aggregation and spreading of tau pathology, which drives neurodegeneration and cognitive decline. However, the pathophysiological link between Aβ and tau remains unclear, which hin...
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice [0.03%]
T细胞三重敲除CD11a、CD49d和PSGL1可降低CAR-T细胞毒性但保留小鼠体内针对实体瘤的活性
Hongye Wang,Zhaorong Wu,Dan Cui et al.
Hongye Wang et al.
Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the landscape of cancer treatment, in particular in the context of hematologic malignancies. However, for solid tumors that lack tumor-specific antigens, CAR-T cells can i...
Florian Jaudas,Florian Bartenschlager,Bachuki Shashikadze et al.
Florian Jaudas et al.
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator therapy, inflammation and infe...
Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice [0.03%]
小鼠巨噬细胞特异性体内RNA编辑促进吞噬作用和抗肿瘤免疫反应
Yuxuan Chen,Xiaohong Chen,Yao Zhang et al.
Yuxuan Chen et al.
Macrophages play a central role in antitumor immunity, making them an attractive target for gene therapy strategies. However, macrophages are difficult to transfect because of nucleic acid sensors that can trigger the degradation of foreign...
A population of c-kit+ IL-17A+ ILC2s in sputum from individuals with severe asthma supports ILC2 to ILC3 trans-differentiation [0.03%]
来自重症哮喘患者痰液中的c-kit⁺ IL-17A⁺ ILC2支持ILC2向ILC3的转分化现象
Xiaotian Ju,Nahal Emami Fard,Anurag Bhalla et al.
Xiaotian Ju et al.
In prednisone-dependent severe asthma, uncontrolled sputum eosinophilia is associated with increased numbers of group 2 innate lymphoid cells (ILC2s). These cells represent a relatively steroid-insensitive source of interleukin-5 (IL-5) and...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy [0.03%]
吸入氙气调节小胶质细胞并改善淀粉样变和tau病模型小鼠的疾病症状
Wesley Brandao,Nimansha Jain,Zhuoran Yin et al.
Wesley Brandao et al.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Antiamyloid antibody treatments modestly slow disease progression in mild dementia due to AD. Emerging evidence shows that homeostatic dysregulation of the brain imm...
Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis [0.03%]
正骨调节黑素皮质素受体4的转录及能量平衡
Baijie Xu,Katherine Lawler,Steven C Wyler et al.
Baijie Xu et al.
Disruption of hypothalamic melanocortin 4 receptors (MC4Rs) causes obesity in mice and humans. Here, we investigated the transcriptional regulation of MC4R in the hypothalamus. In mice, we show that the homeodomain transcription factor Orth...
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease [0.03%]
上皮OPA1将线粒体融合与炎症性肠病联系起来
Li-Li Bao,Yu-Qiang Yu,Miguel González-Acera et al.
Li-Li Bao et al.
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in inte...
Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models [0.03%]
基因治疗改善溶酶体贮积病小鼠模型的肠运动障碍和肠神经元变性并延长其生存期
Ewa A Ziółkowska,Matthew J Jansen,Letitia L Williams et al.
Ewa A Ziółkowska et al.
Children with neurodegenerative disease often have debilitating gastrointestinal symptoms. We hypothesized that this may be due at least in part to underappreciated degeneration of neurons in the enteric nervous system (ENS), the master reg...