Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection [0.03%]
铜绿假单胞菌感染诱发的移植物内淋巴细胞毒性触发肺移植抗体介导排斥反应
Fuyi Liao,Dequan Zhou,Marlene Cano et al.
Fuyi Liao et al.
How pathogens inhibit transplant tolerance remains unclear. Here, we found that Pseudomonas aeruginosa infection, but not other common bacterial respiratory infections, increases antibody-mediated rejection (AMR) risk in recipients of lung ...
Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes [0.03%]
蛋白质组分析揭示了遗传性额颞叶痴呆亚型之间脑脊液特征的差异
Aitana Sogorb-Esteve,Sophia Weiner,Joel Simrén et al.
Aitana Sogorb-Esteve et al.
We used an untargeted mass spectrometric approach, tandem mass tag proteomics, for the identification of proteomic signatures in genetic frontotemporal dementia (FTD). A total of 238 cerebrospinal fluid (CSF) samples from the Genetic FTD In...
Selection and prioritization of candidate combination regimens for the treatment of tuberculosis [0.03%]
结核病治疗候选联合疗法的选择和优先排序
Natasha Strydom,Rob C van Wijk,Qianwen Wang et al.
Natasha Strydom et al.
Accelerated tuberculosis drug discovery has increased the number of plausible multidrug regimens. Testing every drug combination in vivo is impractical, and varied experimental conditions make it challenging to compare results between exper...
Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA-directed autoimmunity in mouse and human [0.03%]
禽型肠球菌转移到肠道中会诱发小鼠和人类TH17和IgG3抗RNA自身免疫反应
Konrad Gronke,Mytien Nguyen,Helen Fuhrmann et al.
Konrad Gronke et al.
Chronic autoimmune diseases often lead to long-term sequelae and require lifelong immunosuppression because of an incomplete understanding of the triggers and drivers in genetically predisposed patients. Gut bacteria that escape the gut bar...
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia [0.03%]
一个广泛的纤毛网络的解体诱导蛋白质稳态和细胞命运的转变导致严重的原发性纤毛运动障碍
Steven L Brody,Jiehong Pan,Tao Huang et al.
Steven L Brody et al.
Primary ciliary dyskinesia is a rare monogenic syndrome that is associated with chronic respiratory disease, infertility, and laterality defects. Although more than 50 genes causative of primary ciliary dyskinesia have been identified, vari...
Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease [0.03%]
器官特异性微环境驱动急性移植物抗宿主病中T细胞的分化演变路径
Kayleigh Ingersoll Omdahl,Rene S Bermea,Ryan Fleming et al.
Kayleigh Ingersoll Omdahl et al.
Tissue-specific T cell immune responses play a critical role in maintaining organ health but can also drive immune pathology during both autoimmunity and alloimmunity. The mechanisms controlling intratissue T cell programming remain unclear...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models [0.03%]
ALS患者早期出现的睡眠障碍在小鼠模型中被食欲素拮抗剂缓解
Simon J Guillot,Christina Lang,Marie Simonot et al.
Simon J Guillot et al.
Sleep alterations have been described in several neurodegenerative diseases yet are currently poorly characterized in amyotrophic lateral sclerosis (ALS). This study investigates sleep macroarchitecture and related hypothalamic signaling di...
Correcting a pathogenic mitochondrial DNA mutation by base editing in mice [0.03%]
借助基因编辑在小鼠中校正病原性线粒体DNA突变
Jose D Barrera-Paez,Sandra R Bacman,Till Balla et al.
Jose D Barrera-Paez et al.
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit in a mouse model that ...
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection [0.03%]
预先接种疫苗可在感染新冠时防止先天免疫反应过度激活
Leslie Chan,Kassandra Pinedo,Mikayla A Stabile et al.
Leslie Chan et al.
At this stage in the COVID-19 pandemic, most infections are "breakthrough" infections that occur in individuals with prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. To refine long-term vaccine strategies against...
AGER-dependent macropinocytosis drives resistance to KRAS-G12D-targeted therapy in advanced pancreatic cancer [0.03%]
依赖AGE的巨胞饮作用驱动了胰腺癌对KRAS-G12D靶向治疗产生耐药性
Changfeng Li,Yuanda Liu,Chang Liu et al.
Changfeng Li et al.
Pancreatic ductal adenocarcinoma (PDAC) driven by the KRAS-G12D mutation presents a formidable health challenge because of limited treatment options. MRTX1133 is a highly selective and first-in-class KRAS-G12D inhibitor under clinical devel...