AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models [0.03%]
靶向AGPAT4的共价抑制剂可增强靶向疗法以克服肝细胞癌小鼠模型中的癌细胞的可塑性
Kai-Yu Ng,Tin-Yan Koo,Ianto Bosheng Huang et al.
Kai-Yu Ng et al.
The development of cancerous cells leads to considerable changes in metabolic processes to meet the demands of tumor growth. Tumor lineage plasticity has been identified as a key factor in therapy resistance and tumor recurrence. Herein, we...
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease [0.03%]
系统的分析细胞串扰揭示了SEMA6D-TREM2在调节阿尔茨海默病的小胶质细胞功能中的作用
Ricardo D&#x;Oliveira Albanus,Gina M Finan,Logan Brase et al.
Ricardo D&#x;Oliveira Albanus et al.
Cellular cross-talk, mediated by membrane receptors and their ligands, is crucial for brain homeostasis and can contribute to neurodegenerative diseases such as Alzheimer's disease (AD). To find cross-talk dysregulations involved in AD, we ...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models [0.03%]
基于mRNA编码的HIV膜结合型包膜三聚体诱导动物模型中产生中和抗体疫苗接种研究
Parham Ramezani-Rad,Christopher A Cottrell,Ester Marina-Zárate et al.
Parham Ramezani-Rad et al.
A protective vaccine against human immunodeficiency virus (HIV) will likely need to induce broadly neutralizing antibodies (bnAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine s...
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis [0.03%]
NFIA通过调节关节软骨细胞脂肪酸代谢维持关节稳态
Cuicui Wang,Liang Fang,Meng Shi et al.
Cuicui Wang et al.
Osteoarthritis (OA) is a joint disease with an etiology partially rooted in metabolic dysfunction, yet the underlying mechanisms in this context are not determined, limiting opportunities to develop therapeutic treatments. In this study, we...
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis [0.03%]
哈钦森-夏科氏病小肠结肠炎的发病机制与神经无髓鞘化对肠上皮再生功能的影响密切相关
Zhen Zhang,Dorothy Lee,Lingya Liu et al.
Zhen Zhang et al.
Hirschsprung disease (HSCR) is a congenital condition characterized by the improper migration of enteric neural crest cells, leading to aganglionosis most commonly in the rectosigmoid colon. This severe and life-threatening disorder often r...
Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss [0.03%]
光学相干层析成像检测到的人耳内液失衡与听力损失相关性研究
Wihan Kim,Dorothy W Pan,Bong Jik Kim et al.
Wihan Kim et al.
Hearing loss and vertigo occur when there is an imbalance between the two inner ear fluids, endolymph and perilymph. The inner ear is a small delicate structure encased in dense bone deep in the base of the skull, making it challenging to i...
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice [0.03%]
组织驻留记忆性CD4⁺T细胞侵入进行性多发性硬化症的中枢神经系统，并促进小鼠慢性自身免疫反应
Aurora Pignata,David Frieser,Carmen Gonzalez-Fierro et al.
Aurora Pignata et al.
Preventing T cell migration to the central nervous system (CNS) has remarkable therapeutic effects in relapsing-remitting multiple sclerosis (RRMS) but is poorly effective against the progressive form (PMS). Disability progression in PMS li...
Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis [0.03%]
用于能量平衡调控而不会引起恶心或呕吐的hindbrain八肽神经胶质递质治疗靶点
Caroline E Geisler,Kylie S Chichura,Oleksandr Orativskyi et al.
Caroline E Geisler et al.
Glia play a dynamic role in central nutrient sensing and appetite regulation yet represent underexplored targets in treating dysregulated energy balance. Glia within the dorsal vagal complex of the hindbrain synthesize the anorexigenic pept...
Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets [0.03%]
对2009年甲型H1N1病毒的既往免疫可减少雪貂感染甲型H5N1病毒及发病的易感性
Katherine H Restori,Veronika Weaver,Devanshi R Patel et al.
Katherine H Restori et al.
Zoonotic infections with emerging influenza viruses occur in the context of population-wide immunity to seasonal strains. Because of the worldwide spread of highly pathogenic clade 2.3.4.4b H5N1 influenza viruses in wild birds, there have b...