Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus [0.03%]
葡糖内酯恢复自身免疫调节并缓解狼疮易感小鼠及皮肤红斑狼疮患者的皮肤炎症
Wei Li,Antonios G A Kolios,Wenliang Pan et al.
Wei Li et al.
Systemic lupus erythematosus (SLE) is characterized by dysfunctional regulatory T cells (Tregs). We previously showed that protein phosphatase 2A (PP2A) plays a critical role in maintaining the suppressive function of Tregs. Here, we analyz...
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma [0.03%]
窗口试验揭示了navtemadlin在复发性胶质母细胞瘤患者中的反应和耐药机制
Veronica Rendo,Eudocia Q Lee,Connor Bossi et al.
Veronica Rendo et al.
Inhibitors of murine double minute homolog 2 (MDM2) represent a promising therapeutic approach for the treatment of TP53 wild-type glioblastomas (GBMs), reactivating p53 signaling to induce cancer cell death. We conducted a surgical window-...
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene [0.03%]
通过暂时抑制一个必需基因在体内扩增基因靶向肝细胞
Marco De Giorgi,So Hyun Park,Adam Castoreno et al.
Marco De Giorgi et al.
Homology-directed repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differenti...
Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade [0.03%]
天然免疫抑制细胞的共激活诱导出对 Toll 样受体激动剂与 PD-1 阻断联合疗法的获得性耐药反应
Hitomi Nishinakamura,Sayoko Shinya,Takuma Irie et al.
Hitomi Nishinakamura et al.
Immune checkpoint blockade therapy has been successfully applied in clinical settings as a standard therapy for many cancer types, but its clinical efficacy is restricted to patients with immunologically hot tumors. Various strategies to mo...
Intestinal epithelium-derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease [0.03%]
肠道上皮细胞衍生的IL-34通过重新编程巨噬细胞来缓解胃肠道移植物抗宿主病
Aditya Rayasam,Alison Moe,Matthew Kudek et al.
Aditya Rayasam et al.
Gastrointestinal (GI) tract graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation and is attributable to dysregulation that occurs between the effector and regulatory arms of the i...
Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons [0.03%]
反义寡核苷酸介导的MSH3抑制可降低亨廷顿病诱导多能干细胞来源的纹状体神经元中的体细胞CAG重复序列扩增
Emma L Bunting,Jasmine Donaldson,Sarah A Cumming et al.
Emma L Bunting et al.
Expanded CAG alleles in the huntingtin (HTT) gene that cause the neurodegenerative disorder Huntington's disease (HD) are genetically unstable and continue to expand somatically throughout life, driving HD onset and progression. MSH3, a DNA...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay [0.03%]
基于高通量蛋白酶激活纳米传感器的胰腺癌早期检测技术
Jose L Montoya Mira,Arnaud Quentel,Ranish K Patel et al.
Jose L Montoya Mira et al.
Pancreatic ductal adenocarcinoma (PDAC) is among the top causes of cancer-related death. Patients are frequently diagnosed in the more advanced stages when effective treatment options are limited; however, earlier detection of PDAC by liqui...
Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming [0.03%]
肿瘤细胞源外泌体PD-L1通过重塑脂代谢促进T细胞衰竭
Feiya Ma,Xia Liu,Yuanqin Zhang et al.
Feiya Ma et al.
The limited success of cancer immunotherapy has posed challenges in treating patients with cancer. However, promising strides could be made with a deeper understanding of the factors that cause T cell dysfunction within the tumor microenvir...
Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma [0.03%]
选择性消除S6K2使脂质稳态成为MAPK抑制剂耐药NRAS突变黑色素瘤的生存弱点
Brittany Lipchick,Adam N Guterres,Hsin-Yi Chen et al.
Brittany Lipchick et al.
Although oncogenic NRAS activates mitogen-activated protein kinase (MAPK) signaling, inhibition of the MAPK pathway is not therapeutically efficacious in NRAS-mutant (NRASMUT) tumors. Here, we report that selectively silencing the ribosomal...
Idaira M Guerrero-Fonseca,Bryan G Yipp
Idaira M Guerrero-Fonseca
Pseudomonas infection after lung transplantation induces acute intragraft lymphocytotoxicity that promotes antibody-mediated rejection in mice (Liao et al., this issue).