Sequential treatment with PARPi and WEE1i enhances antitumor immune responses in preclinical models of ovarian cancer [0.03%]
PARP抑制剂和WEE1抑制剂序贯治疗在卵巢癌的临床前模型中增强抗肿瘤免疫反应
Xiaofei Jiao,Jiahao Liu,Yijie Wu et al.
Xiaofei Jiao et al.
The antitumor activity demonstrated by DNA damage response inhibitors (DDRis) can be partially attributed to their capacity to enhance immune responses. However, the toxicity of DDRis to lymphocytes, particularly when a DDRi is combined wit...
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer [0.03%]
一种口服的血红素氧合酶抑制剂在癌症的临床前模型中靶向免疫抑制性血管周巨噬细胞
Meriem Bahri,Taha Al-Adhami,Emre Demirel et al.
Meriem Bahri et al.
A subset of perivascular tumor-associated macrophages (PvTAMs) expressing lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) relies on heme oxygenase-1 (HO-1) activity to maintain an immunologically cold tumor microenvironment, whi...
Nasal and systemic immune responses correlate with viral shedding after influenza challenge in people with complex preexisting immunity [0.03%]
复杂的既往免疫力人群在流感攻击后的鼻腔和全身免疫反应与病毒脱落相关性研究
Kathie-Anne Walters,Charles A Blatti rd,Ruoqing Zhu et al.
Kathie-Anne Walters et al.
Each year in the United States, ~50% of adults ≥18 years old are vaccinated against influenza viruses, with protective efficacy averaging 40.5% over the past 20 years. To model annual seasonal influenza, a cohort of 74 adults, who were uns...
Circulating epigenetic signatures classifying brain insulin resistance in humans [0.03%]
循环表观遗传特征可对人类脑胰岛素抵抗进行分类
Stephanie Kullmann,Amandeep Singh,Ratika Sehgal et al.
Stephanie Kullmann et al.
Brain insulin action plays an important role in metabolic and cognitive health, but there is no biomarker available to assess brain insulin resistance in humans. Here, we developed a machine learning framework based on blood DNA methylation...
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models [0.03%]
在临床前模型中激活非遗传AHR-ELMSAN1轴可优化BET靶向疗法并抑制白血病干细胞
Xinyue Zhou,Steven Moreira,Cecilia Restelli et al.
Xinyue Zhou et al.
Developing strategies to enhance the response to bromodomain and extraterminal domain (BET) inhibitors and effectively eradicate cancer stem cells would represent a major cancer treatment advance against leukemia. Through a functional CRISP...
Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease [0.03%]
染色体Y丢失通过激活免疫检查点促进衰老细胞的聚集并导致肾功能障碍
Yohei Arai,Nicholas W Chavkin,Yuka Arai et al.
Yohei Arai et al.
The accumulation of senescent cells contributes to morbidity and mortality; however, common mechanisms underpinning this age-associated phenomenon remain elusive. Hematopoietic loss of the Y chromosome (LOY) is the most frequently acquired ...
Jing Li,Xuerui Wang,Andreas I Lackner et al.
Jing Li et al.
During pregnancy, immune responses must balance protection from infections with tolerance of the semiallogeneic fetus. However, the mechanisms regulating maternal-fetal tolerance remain poorly understood. Recently, we identified CD8+ T cell...
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial [0.03%]
一项一期临床试验表明，用编码膜锚定型HIV包膜三聚体的mRNA疫苗诱导出了广义二级中和抗体
K Rachael Parks,Zoe Moodie,Mary A Allen et al.
K Rachael Parks et al.
mRNA technology might accelerate development of an urgently needed preventive human immunodeficiency virus (HIV) vaccine. We evaluated the safety and immunogenicity of three mRNA-encoded envelope trimers, including two doses of soluble and ...
Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide [0.03%]
larazotide治疗儿童新冠后多系统炎症综合征的病毒刺突抗原清除和增强恢复效果研究
Lael M Yonker,Abigail S Kane,Zoe Swank et al.
Lael M Yonker et al.
Multisystem inflammatory syndrome (MIS) is a severe disease that occurs weeks to months after acute infection with SARS-CoV-2, often occurring in children (MISC). Symptoms include high fever, rash, nausea, diarrhea, and abdominal pain. Chil...