Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature [0.03%]
再生障碍性贫血的单细胞分析揭示了具有疾病相关TCR特征的NK和类似NK的CD8+ T细胞的汇聚
Sofie Lundgren,Jani Huuhtanen,Mikko Keränen et al.
Sofie Lundgren et al.
Immune aplastic anemia (AA) is a life-threatening bone marrow failure disorder driven by an autoimmune T cell attack against hematopoietic stem and progenitor cells (HSPCs). However, the exact autoantigen targets and role of other immune ce...
Reduced cerebellar rhythm by climbing fiber denervation is linked to motor rhythm deficits in mice and ataxia severity in patients [0.03%]
攀爬纤维节律降低与小鼠运动节律缺陷和患者失调严重程度有关
Chih-Chun Lin,Ke-Chu Fang,Ilaria Balbo et al.
Chih-Chun Lin et al.
Cerebellar ataxia results from various genetic and nongenetic disorders and is characterized by involuntary movements that impair precision and motor rhythm. Here, we report that climbing fiber (CF) denervation is a common pathophysiology u...
An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics [0.03%]
电粘附水凝胶界面延长了猪胃肠道黏膜的治疗诊断时间
Binbin Ying,Kewang Nan,Qing Zhu et al.
Binbin Ying et al.
Establishing a robust and intimate mucosal interface that allows medical devices to remain within lumen-confined organs for extended periods has valuable applications, particularly for gastrointestinal theranostics. Here, we report the deve...
A gut Eggerthella lenta-derived metabolite impairs neutrophil function to aggravate bacterial lung infection [0.03%]
一种来自Eggerthella lenta的肠道代谢物会损害中性粒细胞功能并加重细菌性肺感染
Le-Le Wang,Xiyue Shen,Yingzhou Xie et al.
Le-Le Wang et al.
The composition of the gut microbiota in patients with bronchiectasis has been proven to be distinct from that of healthy individuals, and this disrupted gut microbiota can exacerbate lung infections. However, the responsible microbes and m...
Bone marrow transplant protects mice from sickle cell-mediated large artery remodeling [0.03%]
骨髓移植保护小鼠免受镰状细胞介导的大动脉重构的影响
Liana Hatoum,Hannah Song,David Alexander et al.
Liana Hatoum et al.
Sickle cell disease (SCD) is a hereditary blood disorder that causes sickling of red blood cells under deoxygenation, which stiffens and damages the cells. Individuals homozygous for the mutant β-globin S allele (SS) endure complications i...
Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model [0.03%]
抑制机械信号转导可防止瘢痕并使大型动物模型中的组织再生成为可能
Shamik Mascharak,Michelle Griffin,Heather E Talbott et al.
Shamik Mascharak et al.
Modulating mechanotransduction by inhibiting yes-associated protein (YAP) in mice yields wound regeneration without scarring. However, rodents are loose-skinned and fail to recapitulate key aspects of human wound repair. We sought to elucid...
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread [0.03%]
靶向科罗纳康哥出血热病毒GP38的抗体限制血管泄露和病毒传播
Felix Pahmeier,Stephanie R Monticelli,Xinyi Feng et al.
Felix Pahmeier et al.
Crimean-Congo hemorrhagic fever virus (CCHFV) is a priority pathogen transmitted by tick bites, with no vaccines or specific therapeutics approved to date. Severe disease manifestations include hemorrhage, endothelial dysfunction, and multi...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome [0.03%]
沃尔弗朗综合征中糖尿病的根本机制：β细胞的去分化现象
Kikuko Amo-Shiinoki,Katsuya Tanabe,Wataru Nishimura et al.
Kikuko Amo-Shiinoki et al.
Insulin-dependent diabetes in patients with Wolfram syndrome (WS; OMIM 222300) has been linked to endoplasmic reticulum (ER) stress caused by WFS1 gene mutations. However, the pathological process of ER stress-associated β cell failure rem...
Dysfunctional CD11c-CD21- extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer [0.03%]
癌症患者外周和肿瘤中功能失调的CD11c-CD21- 额外 follicular 亿 B 细胞增多
Ayana T Ruffin,Allison N Casey,Sheryl R Kunning et al.
Ayana T Ruffin et al.
Many patients with recurrent and metastatic cancer fail to produce a durable response to immunotherapy, highlighting the need for additional therapeutic targets to improve the immune landscape in tumors. Recent studies have highlighted the ...