Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome [0.03%]
贝扎菲布雷改善22q11.2缺失综合征模型中的线粒体功能、血脑屏障完整性和社交缺陷
Alexis M Crockett,Maria C Vélez Colόn,Hanna Kebir et al.
Alexis M Crockett et al.
Maintenance of blood-brain barrier (BBB) integrity is critical to optimal brain function, and its impairment has been linked to multiple neurological disorders. A notable feature of the BBB is its elevated mitochondrial content compared wit...
Ultrahigh-concentration biologic therapeutics enabled by spray drying with a glassy surfactant excipient [0.03%]
通过玻璃化表面活性剂辅料喷雾干燥技术实现超浓度生物药物疗法
Carolyn K Jons,Alexander N Prossnitz,Noah Eckman et al.
Carolyn K Jons et al.
Biopharmaceuticals such as peptides and antibodies have become critical to health care. Despite their exceptional potency and specificity, biopharmaceuticals are prone to aggregation, which can limit efficacy. These therapies therefore ofte...
Talia M Quandelacy,Maria F Vincente-González,Maria Eugenia Grillet et al.
Talia M Quandelacy et al.
Dengue is endemic throughout the tropical areas of the Americas, but little is known about its regional dynamics. We examined seasonal and multiannual dengue trends across the Americas and possible underlying mechanisms using monthly dengue...
High binding potency overcomes the requirement of Fc effector functions for broadly reactive anti-alphavirus antibodies [0.03%]
高抗原结合力可克服广谱抗alphavirus抗体对Fc功能的需求
Victoria Callahan,Matthew S Sutton,Christina L Gardner et al.
Victoria Callahan et al.
Alphaviruses are emerging public health threats. Broadly reactive anti-alphavirus monoclonal antibodies (mAbs) have been shown to be protective in mouse models of infection. However, the antibody characteristics that promote in vivo efficac...
FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity [0.03%]
法尼醇X受体通过增加底物氧化适应肥胖患者肝脏线粒体功能
Katrin Panzitt,Emilian Jungwirth,Lena E Vosko et al.
Katrin Panzitt et al.
Metabolic pressure shifts signaling pathways of nuclear receptors, including the bile acid receptor FXR, which are sensitive to nutritional inputs. We performed an FXR ChIP-seq-centered multiomic analysis of liver biopsy samples from indivi...
Engraftment and persistence of HBB base-edited hematopoietic stem cells in nonhuman primates [0.03%]
人源非人灵长类动物模型中经HBB位点碱基编辑的造血干细胞的植入和长期存活功能评估
Stefan Radtke,Emily Fields,Kyle Swing et al.
Stefan Radtke et al.
Sickle cell disease (SCD) is caused by a single nucleotide change in the β-globin gene that adenine base editors can convert to the nonpathogenic Makassar β-globin variant. Here, we evaluated the long-term efficiency and off-target editin...
Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET [0.03%]
动脉粥样硬化性疾病活性与多种细胞类型中的糖酵解酶表达相关，并可通过FDG-PET进行追踪
Paula Nogales,Carlos Velasco,Leticia González-Cintado et al.
Paula Nogales et al.
Positron emission tomography (PET) imaging with the radiolabeled glucose analog fluorodeoxyglucose (18FDG) is used to monitor atherosclerosis in clinical trials, but there is uncertainty regarding the plaque cell types that accumulate FDG a...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo [0.03%]
受ISG15缺陷启发的一种基于mRNA的广谱抗病毒药物可体内和体外抵抗病毒感染
Yemsratch T Akalu,Roosheel S Patel,Justin Taft et al.
Yemsratch T Akalu et al.
Type I interferons (IFN-Is) are cytokines with potent antiviral and inflammatory capacities. IFN-I signaling drives the expression of thousands of IFN-I-stimulated genes (ISGs), whose aggregate function results in the control of viral infec...
PIEZO1-activated donor lymphatic remodeling integrates with autologous lymphangiogenesis to enhance vein graft patency in mice [0.03%]
PIEZO1激活的供体淋巴管重塑与自体淋巴管生成整合可增强小鼠移植静脉的通畅性
Kai Chen,Rong Mou,Ziyin Guan et al.
Kai Chen et al.
The great saphenous vein is the most commonly used conduit in coronary artery bypass grafting; however, the high vein graft failure rates remain an unresolved issue. Here, we compared different harvesting techniques for mouse vein grafts an...
Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia [0.03%]
CD4+T细胞中的同种抗原反应型前病毒导致HIV-1非抑制性血症
Fengting Wu,Milica Moskovljevic,Filippo Dragoni et al.
Fengting Wu et al.
Antiretroviral therapy (ART) halts human immunodeficiency virus-1 (HIV-1) replication, reducing plasma virus concentrations to below the limit of detection, but it is not curative because of a reservoir of latently infected CD4+ T cells. In...