Base editing of β0-thalassemia mutations as a therapeutic strategy for severe β-hemoglobinopathies [0.03%]
基于编辑治疗严重β型血红蛋白病的β0-地中海贫血基因突变
Giulia Hardouin,Pierre Martinucci,Samantha Scaramuzza et al.
Giulia Hardouin et al.
Gene therapy has emerged as a promising curative treatment for β-hemoglobinopathies, the most common genetic disorders worldwide. However, current approved approaches still have some limitations in terms of safety and efficacy. Here, we us...
Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses [0.03%]
血清交叉反应在虫媒病毒流行病学和抗原性推断中的应用
Megan O&#x;Driscoll,Nathanaël Hozé,Noémie Lefrancq et al.
Megan O&#x;Driscoll et al.
Multiplex immunoassays can facilitate the parallel measurement of antibody responses against multiple antigenically related pathogens, generating a wealth of high-dimensional data that depict complex antibody-antigen relationships. In this ...
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice [0.03%]
鼠源急性髓系白血病模型中淋巴毒素α消除白血病并促进健康造血功能
Ulrike Höckendorf,Sayantanee Dutta,Arnold Kloos et al.
Ulrike Höckendorf et al.
Acute myeloid leukemia (AML) is characterized by frequent relapse, which is driven by resistant leukemic stem or progenitor cells (LSCs). Here, we reported on a tumor-suppressive mechanism that can be harnessed to simultaneously clear LSCs ...
Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum [0.03%]
鲁索利替尼作为辅助治疗可减轻恶性疟原虫实验性感染受试者中的炎症并增强免疫反应
Rebecca Webster,Damian A Oyong,Stacey Llewellyn et al.
Rebecca Webster et al.
Inhibiting the inflammatory response to malaria offers a promising strategy to improve clinical outcomes and overcome immunoregulatory barriers that hinder development of antiparasitic immunity. We conducted a double-blind, randomized, plac...
Randomized Controlled Trial
Science translational medicine. 2025 Nov 26;17(826):eaea2531. DOI:10.1126/scitranslmed.aea2531 2025
A modular metalloprotein in situ vaccine for cancer immunotherapy in mouse models of breast cancer [0.03%]
一种用于乳腺癌小鼠模型的癌症免疫疗法的模块化金属蛋白原位疫苗
Dingkang Liu,Jing Tian,Lichao Yu et al.
Dingkang Liu et al.
Immunogenic cell death (ICD) is a promising approach for generating antitumor immune responses to treat patients with cancer. However, the stereotactic induction of ICD and spatiotemporal synchronized activation of the tumor-specific immune...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice [0.03%]
消除与病毒Fc受体的相互作用可改善抗体介导的小鼠新生儿HSV感染的预防措施
Matthew D Slein,Iara M Backes,Lesle M Jiménez et al.
Matthew D Slein et al.
Herpes simplex virus (HSV) encodes surface glycoproteins that are host defense evasion molecules. For example, glycoproteins E and I (gE/gI) form a viral Fc receptor (vFcR) for most subclasses and allotypes of human IgG, promoting evasion o...
Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma [0.03%]
在神经母细胞瘤的细胞和小鼠模型中，靶抗原展示的细胞外囊泡可增强CAR-T细胞疗效
Anna Maria Giudice,Stephanie Matlaga,Sydney L Roth et al.
Anna Maria Giudice et al.
Glypican-2 (GPC2) and the disialoganglioside GD2 are validated CAR T cell targets in neuroblastoma, but durable clinical responses remain limited. This modest chimeric antigen receptor T cell (CAR T cell) efficacy is in part due to suboptim...
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs [0.03%]
一种针对肠道TGR5受体的载体-药物缀合物可改善小鼠和猪的血糖控制能力
Yaqi Zhang,Hui Huang,Yaying Wang et al.
Yaqi Zhang et al.
Numerous G protein-coupled receptors (GPCRs) expressed in the gastrointestinal tract serve as crucial transducers to regulate a variety of physiological functions upon activation. Takeda G protein-coupled receptor 5 (TGR5), a prominent gast...
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models [0.03%]
一种合理设计的纳米抗体鸡尾酒制剂可通过异源疫苗接种诱导对SFTSV具有保护作用（基于临床前模型）
Xilin Wu,Linjing Zhu,Shengjian Liang et al.
Xilin Wu et al.
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne phlebovirus, poses a growing public health threat, with no approved vaccines or targeted therapies. Its genetic diversity and rapid reassortment have hindered...
Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation [0.03%]
沿造血干细胞淋巴细胞分化 targeting 多发性骨髓瘤的起源
Jiaojiao Guo,Yaru Li,Zhiling Yan et al.
Jiaojiao Guo et al.
The initiation and progression of multiple myeloma (MM) are intricate processes, and a critical challenge lies in understanding the mechanisms of malignant transformation in MM-initiating cells (MICs) and their driver genes. In this study, ...