A complete Sigmodon hispidus genome and dynamic single-cell transcriptomics reveal evolutionarily conserved responses to RSV infection [0.03%]
完整的Sigmodon hispidus基因组和动态单细胞转录组学揭示了对RSV感染的进化保守反应
Shijie Qin,Xiao Qu,Chao Lv et al.
Shijie Qin et al.
The cotton rat (Sigmodon hispidus) has emerged as a preclinical model for human respiratory syncytial virus (RSV) research because of its ability to support effective viral replication and recapitulate disease; however, the mechanisms suppo...
Export by a quorum sensing-controlled drug exporter underlies rifampicin's strong activity against staphylococcal biofilms [0.03%]
群体感应控制的药物外排系统是利福平强效抑制金黄色葡萄球菌生物被膜的作用基础
Yao Liu,Lei He,Ryan Liu et al.
Yao Liu et al.
Biofilm infections on indwelling medical devices are a major cause of health care-associated infection and mortality. Most of these infections are caused by staphylococci. Biofilm formation presents a continued clinical challenge because of...
Longitudinal antibody titers measured after COVID-19 mRNA vaccination can identify individuals at risk for subsequent infection [0.03%]
在接种新冠mRNA疫苗后测量纵向抗体滴度可以识别出后续感染高风险个体
Hyeongki Park,Naotoshi Nakamura,Sho Miyamoto et al.
Hyeongki Park et al.
A key issue in the post-COVID-19 pandemic era is the ongoing administration of COVID-19 vaccines. Repeated vaccination is essential for preparing against currently circulating and newly emerging severe acute respiratory syndrome coronavirus...
David A Haggerty,James R Cazzoli,Marvin A Wayne et al.
David A Haggerty et al.
Endotracheal intubation is a critical medical procedure for protecting a patient's airway. Current intubation technology requires extensive anatomical knowledge, training, technical skill, and a clear view of the glottic opening. However, a...
A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan-lysyl oxidase inhibitor PXS-6302 in mature scars [0.03%]
PXS-6302胰斑状氧化物抑制剂治疗成熟疤痕的随机双盲安慰剂对照一期试验
Natalie Morellini,Peijun Gong,Suzanne Rea et al.
Natalie Morellini et al.
Skin scars remain a substantial clinical challenge because of their impact on appearance and psychological well-being. Lysyl oxidases catalyze collagen cross-linking, a key factor in scar development. Here, we report a randomized, double-bl...
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis [0.03%]
与代谢紊乱相关性脂肪肝炎中肝脏巨噬细胞TIM4介导的摄取细胞功能受损促进肝纤维化
Hongxue Shi,Xiaobo Wang,Christopher Sloas et al.
Hongxue Shi et al.
Hepatocyte apoptosis is a key feature of metabolic dysfunction-associated steatohepatitis (MASH), but the fate of apoptotic hepatocytes in MASH is poorly understood. Here, we explore the hypotheses that clearance of dead hepatocytes by live...
Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer [0.03%]
干扰素诱导的衰老性CD8⁺T细胞可降低抗PD-1免疫治疗在早期三阴性乳腺癌中的疗效
Tong Fu,Xi Jin,Min He et al.
Tong Fu et al.
Triple-negative breast cancers (TNBCs) lack predictive biomarkers to guide immunotherapy, especially during early-stage disease. To address this issue, we used single-cell RNA sequencing, bulk transcriptomics, and pathology assays on sample...
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies [0.03%]
人髓鞘化脑类器官与嵌合的小胶质细胞作为髓鞘再生和再髓鞘治疗的模型
Simona Lange,Martin Ebeling,Athéna Loye et al.
Simona Lange et al.
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are essential for the formation of myelin sheaths and pivotal for maintaining axonal integrity and conduction. Disruption of these cells and the myelin sheaths the...
Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques [0.03%]
人和猕猴流感免疫的功能、免疫遗传和结构收敛性
Maya Sangesland,Ning Li,Yaroslav Tsybovsky et al.
Maya Sangesland et al.
Human B cell immunity to the influenza hemagglutinin (HA) stem, a universal vaccine target, is often stereotyped and immunogenetically restricted, posing hurdles to study outside of humans. Here, we show that cynomolgus macaques vaccinated ...
Type I interferon limits central nervous system autoimmunity by modulating the microRNA-21-FOXO1 axis in pathogenic T helper 17 cells [0.03%]
I型干扰素通过调节有害T辅助细胞17中的microRNA-21-FOXO1轴限制中枢神经系统自身免疫反应
Johnna Francis Varghese,Mai Fujiwara,Amrendra K Ajay et al.
Johnna Francis Varghese et al.
IFN-β, a type I interferon, has been used as a first-line therapy for patients with multiple sclerosis (MS) for more than 30 years; however, the cellular and molecular basis of its therapeutic efficacy remains unclear. Here, we first used ...