Abraham Gihawi,Henry M Wood,Jeremy Clark et al.
Abraham Gihawi et al.
Oncomicrobes are estimated to cause 15% of cancers worldwide. When cancer whole-genome sequencing (WGS) data are collected, the microbes present are also sequenced, allowing the investigation of potential etiological and clinical associatio...
NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors [0.03%]
NF1缺失的ER阳性乳腺癌对CDK4/6抑制剂敏感性不同
Ze-Yi Zheng,Anran Chen,Eric J Jaehnig et al.
Ze-Yi Zheng et al.
Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1low status, identified by copy number loss or low mRNA/protein expression, is associated with endocrine ther...
Periadventitial delivery of mesenchymal stem cells improves vascular remodeling and maturation in arteriovenous fistulas [0.03%]
间充质干细胞的peri adventitial递送可改善动静脉瘘的血管重塑和成熟度
Sreenivasulu Kilari,Randall R DeMartino,Scott L Nyberg et al.
Sreenivasulu Kilari et al.
Worldwide, more than 4 million patients with end-stage kidney disease require hemodialysis through an arteriovenous fistula (AVF). AVFs fail because of venous neointimal hyperplasia (VNH) resulting in venous stenosis formation. A phase 1 ra...
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation [0.03%]
通过刺激HSC依赖性细胞外基质降解来解决纤维化问题
Sachin Sharma,Vijaya Prathigudupu,Carson Cable et al.
Sachin Sharma et al.
Tissue fibrosis arises from a critical imbalance between the production and breakdown of extracellular matrix (ECM) components. Whereas current strategies predominantly focus on curbing ECM production, the possibility of promoting ECM degra...
Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers [0.03%]
滤泡调节性T细胞通过支持浆细胞从生发中心释放促进自身免疫性脑脊髓炎发生发展
Fanny Martinez,Coline Cotineau,Julien Novarino et al.
Fanny Martinez et al.
Follicular regulatory T cells (Tfr cells) constitute a subset of regulatory T cells pivotal to the immune response in germinal centers (GCs) that inhibit autoantibody production. Their role, however, remains ill-defined in autoimmune diseas...
Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression [0.03%]
抗原-Fc融合疗法可在无需全身免疫抑制的情况下降低疱疹性瘭疽模型的严重程度
Soheil Tavakolpour,Ali Nili,Leïla A Munaretto et al.
Soheil Tavakolpour et al.
Pemphigus vulgaris is a B cell-mediated autoimmune disease characterized by autoantibodies targeting desmoglein-3 (Dsg3), a critical adhesion molecule in epithelial tissues. Current treatments rely on broad immunosuppression, highlighting t...
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β-mediated inflammation in mice and humans [0.03%]
膳食饱和脂肪酸促进小鼠和人类肺髓样细胞炎性小体活化及介导的炎症反应
Sam J McCright,Olivia Harding,Julia Chini et al.
Sam J McCright et al.
Resident tissue macrophages and monocytes (RTMs) integrate local and systemic signals to coordinate immune cell function at homeostasis and in response to inflammatory stimuli. Obesity-associated metabolic dysfunction drives the development...
Immune response and clinical severity are shaped by skin-adapted Staphylococcus aureus in chronically infected patients [0.03%]
金黄色葡萄球菌引起的慢性感染患者的免疫反应和临床严重程度受皮肤适应性的影响
Anne Jamet,Xiali Fu,Céline Dietrich et al.
Anne Jamet et al.
Despite the well-described association of skin lesions with Staphylococcus aureus, the distinct ability of clinical isolates to influence the local and systemic inflammatory response in a patient-specific manner is insufficiently characteri...
CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice [0.03%]
CAR-Treg细胞在小鼠胰岛移植中的关联抑制和感染耐受作用
Christine M Wardell,Vivian C W Fung,Eleanor Chen et al.
Christine M Wardell et al.
Regulatory T cells (Treg cells) have potential as a cell-based therapy to prevent or treat transplant rejection and autoimmunity. Using a human leukocyte antigen (HLA)-A2-specific chimeric antigen receptor (A2-CAR), we previously showed tha...
An epitope vaccine derived by analyzing clinical trial samples safeguards hosts with prior exposure to S. aureus against reinfection [0.03%]
通过分析临床试验样本衍生的抗原表位疫苗可保护金黄色葡萄球菌感染康复者免受再次感染
Xiaokai Zhang,Shuang Ge,Yu Wang et al.
Xiaokai Zhang et al.
Humans, as natural carriers of Staphylococcus aureus (SA), have developed nonprotective immune imprints that can be reactivated by SA antigen vaccination and that contribute to the failure of SA vaccine trials. To test whether an epitope-fo...