A humanized antibody against mucormycosis targets angioinvasion and augments the host immune response [0.03%]
针对毛霉菌病的人源化抗体靶向血管侵袭并增强宿主免疫反应
Yiyou Gu,Shakti Singh,Abdullah Alqarihi et al.
Yiyou Gu et al.
Mucormycosis is a fungal infection caused by Mucorales fungi that cause severe disease and fatality, especially in immunocompromised individuals. Although vaccines and immunotherapeutics have been successful in combating viral and bacterial...
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques [0.03%]
五聚体复合物对于单纯性CMV传输并非必要条件——以血清阴性的恒河猴为例
Hsuan-Yuan Wang,Husam Taher,Craig N Kreklywich et al.
Hsuan-Yuan Wang et al.
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed o...
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis [0.03%]
人类组氨酰-tRNA合成酶剪接变异体通过作用于NRP2来缓解肺部炎症和纤维化作为治疗方法
Leslie A Nangle,Zhiwen Xu,David Siefker et al.
Leslie A Nangle et al.
Interstitial lung disease (ILD) consists of a group of immune-mediated disorders that can cause inflammation and progressive fibrosis of the lungs, representing an area of unmet medical need given the lack of disease-modifying therapies and...
Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair [0.03%]
人工制造软骨成熟在随机多中心关节软骨修复试验中的临床意义
Marcus Mumme,Anke Wixmerten,Alan Ivkovic et al.
Marcus Mumme et al.
Cartilage lesions do not heal spontaneously and predispose to osteoarthritis. Functional cartilage tissues, engineered using autologous chondrocytes, have a therapeutic advantage over conventional cellular therapies in preclinical studies. ...
A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants [0.03%]
极早早产儿出生后两个月内循环免疫细胞的单细胞图谱
Oluwabunmi Olaloye,Weihong Gu,Arne Gehlhaar et al.
Oluwabunmi Olaloye et al.
Extremely premature infants (EPIs) who are born before 30 weeks of gestation are susceptible to infection; however, the trajectory of their peripheral immunity is poorly understood. Here, we undertook longitudinal analyses of immune cells f...
Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming [0.03%]
通过调节STING-NLRP3介导的肿瘤免疫微环境重塑，靶向GOLPH3L改善胶质母细胞瘤放射治疗
Shuo Sun,Shiyu Qian,Ran Wang et al.
Shuo Sun et al.
Radiotherapy (RT) has been the standard-of-care treatment for patients with glioblastoma (GBM); however, the clinical effectiveness is hindered by therapeutic resistance. Here, we demonstrated that the tumor immune microenvironment (TIME) e...
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern [0.03%]
靶向N端和受体结合域的双特异性抗体能有效中和值得关注的SARS-CoV-2变异株
Adonis A Rubio,Viren A Baharani,Bernadeta Dadonaite et al.
Adonis A Rubio et al.
The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are...
An oral norovirus vaccine tablet was safe and elicited mucosal immunity in older adults in a phase 1b clinical trial [0.03%]
一项一期临床试验表明口服诺如疫苗药片对老年人来说是安全的并能引起黏膜免疫反应
Becca A Flitter,Susan N Greco,Colin A Lester et al.
Becca A Flitter et al.
Norovirus is a leading cause of acute gastroenteritis globally, with infections in older adults associated with heightened severity and increased risk of mortality. Currently, no licensed vaccines are available to prevent norovirus infectio...
Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus [0.03%]
针对人类诺如病毒七种GII基因型或流行性GII.4变异株的广谱中和抗体
Juyeon Park,Lisa C Lindesmith,Adam S Olia et al.
Juyeon Park et al.
Human norovirus causes more than 700 million illnesses annually. Extensive genetic diversity and a paucity of information on conserved neutralizing epitopes pose major obstacles to the design of broadly protective norovirus immunogens. Here...
BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease [0.03%]
BCKDHA-BCKDHB 二元基因疗法恢复了两种小鼠模型和一头经典枫糖尿症牛的代谢稳态
Jiaming Wang,Laura E Poskitt,Jillian Gallagher et al.
Jiaming Wang et al.
Classic maple syrup urine disease (MSUD) results from biallelic mutations in genes that encode the branched-chain α-ketoacid dehydrogenase E1α (BCKDHA), E1β (BCKDHB), or dihydrolipoamide branched-chain transacylase (DBT) subunits, which ...