Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer [0.03%]
干扰素诱导的衰老性CD8⁺T细胞可降低抗PD-1免疫治疗在早期三阴性乳腺癌中的疗效
Tong Fu,Xi Jin,Min He et al.
Tong Fu et al.
Triple-negative breast cancers (TNBCs) lack predictive biomarkers to guide immunotherapy, especially during early-stage disease. To address this issue, we used single-cell RNA sequencing, bulk transcriptomics, and pathology assays on sample...
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies [0.03%]
人髓鞘化脑类器官与嵌合的小胶质细胞作为髓鞘再生和再髓鞘治疗的模型
Simona Lange,Martin Ebeling,Athéna Loye et al.
Simona Lange et al.
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are essential for the formation of myelin sheaths and pivotal for maintaining axonal integrity and conduction. Disruption of these cells and the myelin sheaths the...
Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques [0.03%]
人和猕猴流感免疫的功能、免疫遗传和结构收敛性
Maya Sangesland,Ning Li,Yaroslav Tsybovsky et al.
Maya Sangesland et al.
Human B cell immunity to the influenza hemagglutinin (HA) stem, a universal vaccine target, is often stereotyped and immunogenetically restricted, posing hurdles to study outside of humans. Here, we show that cynomolgus macaques vaccinated ...
Type I interferon limits central nervous system autoimmunity by modulating the microRNA-21-FOXO1 axis in pathogenic T helper 17 cells [0.03%]
I型干扰素通过调节有害T辅助细胞17中的microRNA-21-FOXO1轴限制中枢神经系统自身免疫反应
Johnna Francis Varghese,Mai Fujiwara,Amrendra K Ajay et al.
Johnna Francis Varghese et al.
IFN-β, a type I interferon, has been used as a first-line therapy for patients with multiple sclerosis (MS) for more than 30 years; however, the cellular and molecular basis of its therapeutic efficacy remains unclear. Here, we first used ...
Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity [0.03%]
日本脑炎病毒免疫减弱会加重登革热病情
Sidharth Malhotra,Birendra P Gupta,Surendra Uranw et al.
Sidharth Malhotra et al.
Owing to increased global movement, vector-spread permissive climate change, and increased vaccination coverage against certain flaviviruses, the likelihood of being exposed to multiple flaviviruses in a lifetime has increased. Although man...
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins [0.03%]
针对新型冠状病毒祖先毒株和XBB.1.5刺突蛋白的XB.1.5新冠疫苗可诱导持久的抗体反应
Sanjeev Kumar,Shilpi Jain,Bushra Wali et al.
Sanjeev Kumar et al.
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023-2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen. To determine the durability and breadth of the antibody res...
High-throughput synthesis and specificity characterization of natively paired influenza hemagglutinin antibodies with oPool+ display [0.03%]
用于表征天然配对流感血凝素抗体特异性的高通量oPool+显示技术
Wenhao O Ouyang,Huibin Lv,Wenkan Liu et al.
Wenhao O Ouyang et al.
Antibody discovery is crucial for developing therapeutics and vaccines and for understanding adaptive immunity. However, the lack of approaches to synthesize antibodies with defined sequences in a high-throughput manner represents a major b...
An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer [0.03%]
一种无等位基因特异性的靶向抑制KRAS突变的小分子化合物能抑制胰腺癌的肿瘤维持信号并重编程免疫系统
Kathleen M McAndrews,Francesca Paradiso,Clint A Stalnecker et al.
Kathleen M McAndrews et al.
KRAS is among the most frequently mutated oncogenes in cancer, and for decades, efforts at pharmacological blockade of its function in solid cancers have been unsuccessful. A notable advance in this endeavor is the recent development of sma...
Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project [0.03%]
肿瘤基因组图谱计划全基因组测序样本中的微生物综合分析
Yuchen Ge,Jennifer Lu,Daniela Puiu et al.
Yuchen Ge et al.
In recent years, a growing number of publications have reported the presence of microbial species in human tumors and mixtures of microbes that appear to be highly specific to different cancer types. Our recent reanalysis of data from three...
Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension [0.03%]
抑制SLC38A2可降低高血压小鼠模型的血压
Chunxiu Du,Hu Xu,Wenqian Zhao et al.
Chunxiu Du et al.
Hypertension remains a major global health burden with limited effective treatment options. In the present study, the sodium-dependent neutral amino acid transporter SLC38A2 was identified as a regulator of blood pressure (BP) through modul...