Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans [0.03%]
蜱虫吸血或使用蜱抗原接种疫苗可使豚鼠和人类对Ixodes scapularis外泌蛋白产生免疫反应
Thomas M Hart,Yingjun Cui,Sam R Telford et al.
Thomas M Hart et al.
Ixodes scapularis is a primary vector of tick-borne pathogens in North America. Repeated exposure to these ticks can induce a humoral response to tick antigens and acquired tick resistance. However, identifying antigens contributing to this...
Identification and characterization of human retinal stem cells capable of retinal regeneration [0.03%]
能够进行视网膜再生的人类视网膜干细胞的鉴定与表征
Hui Liu,Yunlong Ma,Na Gao et al.
Hui Liu et al.
Human retinal stem cells hold great promise in regenerative medicine, yet their existence and characteristics remain elusive. Here, we performed single-cell multiomics and spatial transcriptomics of human fetal retinas and uncovered a cell ...
Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome [0.03%]
内部神经元特异性的双重AAV SCN1A基因置换纠正了Dravet综合征小鼠模型中的癫痫表型
John K Mich,Jiyun Ryu,Aguan D Wei et al.
John K Mich et al.
Dravet syndrome (DS) is a severe developmental epileptic encephalopathy marked by treatment-resistant seizures, developmental delay, intellectual disability, motor deficits, and a 10 to 20% rate of premature death. Most patients with DS har...
Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy [0.03%]
托法替尼治疗两周对慢性癫痫小鼠模型疾病修饰作用研究
Olivia R Hoffman,Jennifer L Koehler,Jose Ezekiel Clemente Espina et al.
Olivia R Hoffman et al.
All current drug treatments for epilepsy, a neurological disorder affecting more than 50 million people, merely treat symptoms, and a third of patients with epilepsy do not respond to medication. There are no disease-modifying treatments th...
BASTA, a simple whole-blood assay for measuring β cell antigen-specific CD4+ T cell responses in type 1 diabetes [0.03%]
BASTA，一种简单的全血检验用于测量1型糖尿病的β细胞抗原特异性CD4阳性T细胞反应
Matthew Lacorcia,Pushpak Bhattacharjee,Abby Foster et al.
Matthew Lacorcia et al.
Type 1 diabetes (T1D) is an autoimmune disease where T cells mediate the destruction of the insulin-producing β cells found within the islets of Langerhans in the pancreas. Autoantibodies to β cell antigens are the only tests available to...
T cell receptor precision editing of regulatory T cells for celiac disease [0.03%]
用于治疗乳糜泻的调节性T细胞精准编辑技术研究
Raphaël Porret,Ana Alcaraz-Serna,Benjamin Peter et al.
Raphaël Porret et al.
Celiac disease, a gluten-sensitive enteropathy, demonstrates a strong human leukocyte antigen (HLA) association, with more than 90% of patients carrying the HLA-DQ2.5 allotype. No therapy is available for the condition except for a lifelong...
Itay Raphael,Zujian Xiong,Chaim T Sneiderman et al.
Itay Raphael et al.
The diverse T cell receptor (TCR) repertoire confers the ability to recognize an almost unlimited array of antigens. Characterization of antigen specificity of tumor-infiltrating lymphocytes (TILs) is key for understanding antitumor immunit...
Itaconate restrains acute proinflammatory activation of microglia MG after traumatic brain injury in mice [0.03%]
创伤性脑损伤后鼠微胶质细胞的急性促炎激活被伊塔龙酸抑制
Ning Liu,Yinghua Jiang,Yuwen Xiu et al.
Ning Liu et al.
Traumatic brain injury (TBI) rapidly triggers proinflammatory activation of microglia, contributing to secondary brain damage post-TBI. Although the governing role of energy metabolism in shaping the inflammatory phenotype and function of i...
Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models [0.03%]
术后粘连在临床前模型中被持续释放的抗JUN药物减轻
Deshka S Foster,Jason L Guo,Emily Meany et al.
Deshka S Foster et al.
Postoperative abdominal adhesions are the leading cause of bowel obstruction and a cause of chronic pain and infertility. Adhesion formation occurs after 50 to 90% of abdominal operations and has no proven preventative or treatment strategy...
Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models [0.03%]
对卵巢癌小鼠模型的腹腔热免疫联合疗法的支持的异质性细胞对高热的反应
Xingyuan Hu,Xiaoyan Kang,Faming Zhao et al.
Xingyuan Hu et al.
The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of ...