Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models [0.03%]
人多能干细胞衍生的肾原基细胞可治疗小鼠急性及慢性肾脏病模型
Toshikazu Araoka,Kosuke Toyohara,Makoto Ryosaka et al.
Toshikazu Araoka et al.
The number of patients requiring dialysis therapy continues to increase worldwide because of the lack of effective treatments for chronic kidney disease (CKD). Furthermore, no curative treatments for acute kidney injury (AKI) have been esta...
Clinically compliant enrichment of human pluripotent stem cell-derived islets [0.03%]
符合临床要求的人多能干细胞来源胰岛的富集方法
Bahareh Rajaei,Amadeo Muñoz Garcia,Juri Juksar et al.
Bahareh Rajaei et al.
Human pluripotent stem cell-derived islet (SC-islet) transplantation is a promising β cell replacement therapy for patients with type 1 diabetes, offering a potential unlimited cell supply. Yet, the heterogeneity of the final cell product ...
Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial [0.03%]
一项二期临床试验显示：对于可卡因使用障碍患者，Mavoglurant能减少其可卡因的使用
Baltazar Gomez-Mancilla,Kenneth M Dürsteler,Marc Vogel et al.
Baltazar Gomez-Mancilla et al.
Metabotropic glutamate receptor 5 (mGluR5) is involved in cocaine reward processing and addiction. Preclinical studies suggest that blocking this receptor inhibits cocaine self-administration and seeking behavior in rodents. We assessed a s...
Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis [0.03%]
少突胶质前体细胞调节多发性硬化小鼠模型的免疫反应和早期脱髓鞘病变
Qi Wang,Taida Huang,Zihan Zheng et al.
Qi Wang et al.
Reproducing the pathophysiology of human multiple sclerosis (MS) in animal models is critical to identifying mechanisms triggering demyelination and to developing early intervention strategies. Here, we aimed to model overactivated Wnt (win...
Marlena Fejzo
Marlena Fejzo
Identification of GDF15 as a cause of severe nausea and vomiting during pregnancy is opening new doors for treatment and prevention.
Ebola virus vaccination elicits Ebola virus-specific immune responses without substantial cross-reactivity to other filoviruses [0.03%]
伊波拉病毒疫苗引发特异性免疫反应但不会引起其他丝状病毒交叉免疫反应
Thembi Mdluli,Suzanne Wollen-Roberts,Mélanie Merbah et al.
Thembi Mdluli et al.
The Janssen Ebola virus (EBOV) vaccine consists of the adenovirus type 26 vector encoding the EBOV glycoprotein (GP) (Ad26.ZEBOV) and the modified vaccinia Ankara (MVA) vector encoding GP from EBOV, Sudan virus, and Marburg virus and nucleo...
CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo [0.03%]
基于完全人T细胞受体模拟抗体的CAR T细胞表现出强大的体内抗肿瘤活性
Robert Salzler,David J DiLillo,Kei Saotome et al.
Robert Salzler et al.
Monoclonal antibody therapies have transformed the lives of patients across a diverse range of diseases. However, antibodies can usually only access extracellular proteins, including the extracellular portions of membrane proteins that are ...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone [0.03%]
生存模拟和药代动力学模拟显示硝磺酮对按蚊的杀灭作用
Lee R Haines,Anna Trett,Clair Rose et al.
Lee R Haines et al.
One approach to interrupting the transmission of insect-borne diseases that is successfully used in veterinary medicine is exploiting the ability of antiparasitic drugs to make vertebrate blood toxic for blood-feeding insects. Recent studie...
Variant screening of PYY3-36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity [0.03%]
PYY3-36的变异筛选导致了具有更优Y2受体选择性的强效长效PYY类似物的产生
Søren Østergaard,Carsten Jessen,Johan F Paulsson et al.
Søren Østergaard et al.
Peptide YY (PYY3-36) has attracted attention in diabetes and obesity research because of its involvement in food intake regulation and glucose homeostasis. Native PYY3-36 maintains high potency on the Y2 receptor with a loss of potency on t...
Zhuang Li,Weituo Zhang,Xiao Ying Wei et al.
Zhuang Li et al.
Osteoarthritis (OA) is a prevalent joint disease characterized by pain, disability, and loss of physical function, posing a challenge to public health. However, molecular mechanisms of OA pathogenesis have not been fully described. We repor...