CAR T cell-mediated bone marrow inflammation causes hematotoxicity and favors clonal hematopoiesis [0.03%]
CAR-T细胞介导的骨髓炎症导致血液毒性和有利于克隆造血
Myriam Ben Khelil,Ahmadreza Arbab,Janesa Srikanthan et al.
Myriam Ben Khelil et al.
Although chimeric antigen receptor (CAR) T cells have shown excellent results in treating hematological malignancies, they also cause side effects. Patients treated with CAR T cells experience persistent cytopenia or hematotox. Here, using ...
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles [0.03%]
性别差异与HIV-1库细胞选择相关并导致固有免疫谱型改变
Toong Seng Tan,Ce Gao,Alexander S Hochroth et al.
Toong Seng Tan et al.
HIV-1 persistence despite suppressive antiretroviral therapy (ART) is primarily because of infected memory CD4 T cells, so-called viral reservoir cells, that harbor chromosomally integrated viral DNA as a "provirus" and resist clearance by ...
PD-1-targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer [0.03%]
人源肺癌模型中PD-1介导的细胞内递送IL-2突变体诱导多功能抗肿瘤T细胞应答
Irene Fusi,Clara Serger,Petra Herzig et al.
Irene Fusi et al.
Antibody-cytokine fusion proteins are being developed as next-generation cancer immunotherapies, aiming to deliver activation signals to targeted immune populations. Among these, PD1-IL2v-an engineered interleukin-2 variant (IL-2v) lacking ...
Hippocampal spreading depolarization as a driver of postictal ambulation [0.03%]
海马扩散去极化作为阵发性游走的驱动因素
Bence Mitlasóczki,Adrián Gutiérrez Gómez,Midia Kamali et al.
Bence Mitlasóczki et al.
Postseizure (postictal) symptoms are regularly encountered in epilepsy and can be life threatening, yet their neurobiological underpinnings remain understudied. Using two-photon or widefield imaging, field potential and unit recordings, opt...
A complete Sigmodon hispidus genome and dynamic single-cell transcriptomics reveal evolutionarily conserved responses to RSV infection [0.03%]
完整的Sigmodon hispidus基因组和动态单细胞转录组学揭示了对RSV感染的进化保守反应
Shijie Qin,Xiao Qu,Chao Lv et al.
Shijie Qin et al.
The cotton rat (Sigmodon hispidus) has emerged as a preclinical model for human respiratory syncytial virus (RSV) research because of its ability to support effective viral replication and recapitulate disease; however, the mechanisms suppo...
Export by a quorum sensing-controlled drug exporter underlies rifampicin's strong activity against staphylococcal biofilms [0.03%]
群体感应控制的药物外排系统是利福平强效抑制金黄色葡萄球菌生物被膜的作用基础
Yao Liu,Lei He,Ryan Liu et al.
Yao Liu et al.
Biofilm infections on indwelling medical devices are a major cause of health care-associated infection and mortality. Most of these infections are caused by staphylococci. Biofilm formation presents a continued clinical challenge because of...
Longitudinal antibody titers measured after COVID-19 mRNA vaccination can identify individuals at risk for subsequent infection [0.03%]
在接种新冠mRNA疫苗后测量纵向抗体滴度可以识别出后续感染高风险个体
Hyeongki Park,Naotoshi Nakamura,Sho Miyamoto et al.
Hyeongki Park et al.
A key issue in the post-COVID-19 pandemic era is the ongoing administration of COVID-19 vaccines. Repeated vaccination is essential for preparing against currently circulating and newly emerging severe acute respiratory syndrome coronavirus...
David A Haggerty,James R Cazzoli,Marvin A Wayne et al.
David A Haggerty et al.
Endotracheal intubation is a critical medical procedure for protecting a patient's airway. Current intubation technology requires extensive anatomical knowledge, training, technical skill, and a clear view of the glottic opening. However, a...
A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan-lysyl oxidase inhibitor PXS-6302 in mature scars [0.03%]
PXS-6302胰斑状氧化物抑制剂治疗成熟疤痕的随机双盲安慰剂对照一期试验
Natalie Morellini,Peijun Gong,Suzanne Rea et al.
Natalie Morellini et al.
Skin scars remain a substantial clinical challenge because of their impact on appearance and psychological well-being. Lysyl oxidases catalyze collagen cross-linking, a key factor in scar development. Here, we report a randomized, double-bl...
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction-associated steatohepatitis [0.03%]
与代谢紊乱相关性脂肪肝炎中肝脏巨噬细胞TIM4介导的摄取细胞功能受损促进肝纤维化
Hongxue Shi,Xiaobo Wang,Christopher Sloas et al.
Hongxue Shi et al.
Hepatocyte apoptosis is a key feature of metabolic dysfunction-associated steatohepatitis (MASH), but the fate of apoptotic hepatocytes in MASH is poorly understood. Here, we explore the hypotheses that clearance of dead hepatocytes by live...