Pentatricopeptide repeat protein targeting CUG repeat RNA ameliorates RNA toxicity in a myotonic dystrophy type 1 mouse model [0.03%]
靶向CUG重复序列RNA的五肽重复蛋白可缓解包涵体肌炎小鼠模型中的RNA毒性
Takayoshi Imai,Maiko Miyai,Joe Nemoto et al.
Takayoshi Imai et al.
Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder caused by the expansion of a CTG-triplet repeat in the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. It results in the transcri...
Liver-targeted allergen immunotherapy rapidly and safely induces antigen-specific tolerance to treat allergic airway disease in mice [0.03%]
肝靶向过敏免疫治疗能迅速而安全地诱导小鼠特异性耐受性以治疗过敏性呼吸道疾病
J Emiliano Gómez Medellín,Trevor W M Ung,Thomas Wang et al.
J Emiliano Gómez Medellín et al.
Current asthma treatments manage disease symptoms but fail to address the underlying cause of allergic disease. Allergen immunotherapy holds the promise for durable disease control by establishing allergen-specific tolerance through repeate...
The response to anti-PD-1 and anti-LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming [0.03%]
抗PD-1和抗LAG-3检查点阻断的反应与调节性T细胞重编程相关
Annah S Rolig,Xiyu Peng,Elizabeth R Sturgill et al.
Annah S Rolig et al.
Immune checkpoint blockade (ICB) has revolutionized cancer treatment; however, many patients develop therapeutic resistance. We previously identified and validated a pretreatment peripheral blood biomarker, characterized by a high frequency...
Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice [0.03%]
胶原蛋白V调节肾损伤后的肾功能并可以被药理学靶向以增强小鼠的肾脏修复
Lianjiu Su,Qihao Sun,Yusheng Li et al.
Lianjiu Su et al.
Kidney fibrosis determines clinical outcomes in individuals with chronic kidney disease (CKD). The stoichiometric ratio of collagens in renal scar differs from that of healthy kidney extracellular matrix (ECM), but the functional importance...
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay [0.03%]
低成本便携式实验室试管检测法实现呼吸或血液样本的快速结核病诊断
Brady M Youngquist,Julian Saliba,Yelim Kim et al.
Brady M Youngquist et al.
Rapid portable assays are needed to improve diagnosis, treatment, and reduce transmission of tuberculosis (TB), but current tests are not suitable for patients in resource-limited settings with high TB burden. Here we report a low complexit...
Prasad Palani Velu,Roxanna E Abhari,Neil C Henderson
Prasad Palani Velu
Organ fibrosis causes major morbidity and mortality worldwide. Treatments for fibrosis are limited, with organ transplantation being the only cure. Here, we review how various state-of-the-art spatial genomics approaches are being deployed ...
Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism [0.03%]
富丁酸盐的肿瘤细胞源性微颗粒可重编程肿瘤相关巨噬细胞代谢状态
Shuya Lu,Jiexiao Li,Yonggang Li et al.
Shuya Lu et al.
The tumor microenvironment predominantly polarizes tumor-associated macrophages (TAMs) toward an M2-like phenotype, thereby inhibiting antitumor immune responses. This process is substantially affected by metabolic reprogramming; however, r...
The mRNA export pathway licenses viral mimicry response and antitumor immunity by actively exporting nuclear retroelement transcripts [0.03%]
主动输出核逆转录元件转录本的mRNA出口途径授权病毒模拟反应和抗肿瘤免疫功能
Xiaoqiang Wang,Jiaxing Jin,Han Yan et al.
Xiaoqiang Wang et al.
Nuclear retroelement transcripts (RTs), which can be elicited both transcriptionally and posttranscriptionally, form double-stranded RNA (dsRNA) in cytosol to trigger the viral mimicry response (VMR) and antitumor immunity. However, the str...
Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome [0.03%]
自调节基因治疗改善雷特综合征小鼠模型表型并克服剂量敏感性
Paul D Ross,Kamal K E Gadalla,Sophie R Thomson et al.
Paul D Ross et al.
Conventional methods of gene transfer lead to inconsistent transgene expression within cells. This variability can be problematic, particularly in conditions like Rett syndrome (RTT), a neurological disorder caused by mutations in the MECP2...