Gregory M Rosenberg,Kevin A Murray,Michael R Sawaya et al.
Gregory M Rosenberg et al.
The conversion of proteins into insoluble fibrillar aggregates known as amyloid occurs in a wide variety of diseases, e.g., Alzheimer's disease, amyotrophic lateral sclerosis, systemic transthyretin amyloidosis, and multisystem atrophy. The...
Cholesterol desensitizes the response of endometrial cancer to progestin by attenuating progestin signaling [0.03%]
胆固醇通过减弱孕激素信号使子宫内膜癌产生耐药性
Jiali Hu,Lulu Wang,Bingyi Yang et al.
Jiali Hu et al.
Progestin is the primary fertility-preserving treatment for patients with endometrial cancer (EC) and its precursor lesions, endometrial atypical hyperplasia (EAH); however, a subset of patients exhibits a poor response. In this study, thro...
Severe asthma is characterized by a sex-specific ILC landscape and aberrant airway profile that is suppressed by anti-IL-5/5Rα biologics [0.03%]
严重哮喘具有性别特异性的肺驻留天然淋巴细胞浸润和异常的气道表型，可被抗IL-5/5Rα生物制剂抑制
Kyle T Mincham,Lola E Loewenthal,Garance F M Meyer et al.
Kyle T Mincham et al.
Innate lymphoid cells (ILCs) fulfill critical roles in maintenance of tissue-specific homeostasis but have also been implicated in disease pathology when dysregulated. Although they are broadly classified into three core subsets, it is incr...
S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models [0.03%]
以啮目动物模型中的糖尿病血管并发症治疗靶点S-亚硝基谷胱甘肽还原酶为例
Shuang Zhao,Tianyu Song,Xin Tang et al.
Shuang Zhao et al.
Endothelial dysfunction is one of the earliest processes in diabetes and a major contributor to diabetic vascular complications, which often exhibit limited response to glucose-lowering therapies. We identified up-regulated S-nitrosoglutath...
USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts [0.03%]
USP5抑制通过泛素介导的AML1-ETO降解在患者来源异种移植瘤中使t(8;21)急性髓系白血病治疗成为可能
Lan Ma,Kun Zhang,Zixuan Zhang et al.
Lan Ma et al.
The AML1-ETO (AE) fusion protein is a key target for treating t(8;21) acute myeloid leukemia (AML). In this investigation, we identified ubiquitin-specific protease 5 (USP5) as the deubiquitinating enzyme of AE. USP5 knockdown decreased AML...
Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion [0.03%]
人胰腺导管腺癌的空间分析揭示了与静脉侵犯相关的分子改变
Alexander T F Bell,Peter Chianchiano,Katsuya Hirose et al.
Alexander T F Bell et al.
In pancreatic ductal adenocarcinoma (PDAC), venous invasion (VI) is a critical step in metastasis and is associated with poor survival. However, little is known about the molecular features of VI. To investigate, we performed spatial transc...
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice [0.03%]
视网膜多不饱和脂肪酸补充可逆转小鼠年龄相关性视力下降
Fangyuan Gao,Emily Tom,Cezary Rydz et al.
Fangyuan Gao et al.
The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), primarily localized in cell membranes, where they govern membrane biophysical properties. During aging, alterations in lipid metabolism lead to reduced content of very ...
Afucosylation of anti-dengue IgG is associated with enhanced susceptibility to dengue virus infection postvaccination [0.03%]
疫苗接种后抗登革热IgG的去岩藻糖基化与登革病毒再感染易感性增强有关
Usama Ashraf,Saborni Chakraborty,Courtney Scallan et al.
Usama Ashraf et al.
Dengue viruses (DENVs) cause 390 million infections annually, although only ~25% of these infections are symptomatic. Whereas antibody features linked to severe DENV disease are well studied, factors influencing infection susceptibility rem...
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation [0.03%]
系统性炎症和T细胞及B细胞功能障碍决定易感个体向类风湿关节炎的发展方向
Ziyuan He,Marla C Glass,Pravina Venkatesan et al.
Ziyuan He et al.
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention ...