An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques [0.03%]
肌内注射疫苗和黏膜加强疫苗可保护食蟹猴免受高致病性H5N1流感病毒的致命感染
Ninaad Lasrado,Liping Wang,Jinyan Liu et al.
Ninaad Lasrado et al.
The H5N1 clade 2.3.4.4b avian influenza virus outbreak in poultry and dairy cattle is a potential pandemic threat for humans. A safe and effective H5N1 influenza vaccine will be needed if the virus acquires the capacity for efficient human-...
Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses [0.03%]
系列多组学揭示了常规临床分析中未显现的胶质母细胞瘤抗肿瘤反应
Alexander L Ling,Jennifer Gantchev,Michael C Prabhu et al.
Alexander L Ling et al.
Recurrent glioblastoma (rGBM) remains incurable. One barrier to the development of effective rGBM therapies is the difficulty in collecting posttreatment tumor tissue. Serial multiomic assays from longitudinal rGBM biopsies may uncover tumo...
Sprayable extracellular matrix hydrogel reduces postoperative adhesion formation and protects healing tissues in preclinical models [0.03%]
喷洒型细胞外基质水凝胶可减少临床前模型术后粘连的形成并保护组织在修复过程中的健康状态
Lucía Pascual-Antón,Pilar Sandoval,Henar Tomero-Sanz et al.
Lucía Pascual-Antón et al.
Tissue trauma initiates inflammation that can lead to fibrotic complications such as postoperative peritoneal adhesions, which contribute to chronic pain, infertility, and bowel obstruction. Despite their prevalence and impact, effective in...
Pedro R Lowenstein
Pedro R Lowenstein
Multiomics on serial glioblastoma biopsies can enable differentiation of pseudoprogression from true tumor progression (see Ling et al.).
Immune signatures link myelin oligodendrocyte glycoprotein antibody-associated disease to other autoantibody-mediated conditions [0.03%]
免疫特征将髓磷脂少突胶质细胞糖蛋白抗体相关疾病与其他自身抗体介导的疾病联系起来
Jonas Schmid,Chiara Alberti,Laura Power et al.
Jonas Schmid et al.
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined neurological autoimmune condition. The pathogenesis of the disease remains poorly understood, and no specific therapies are currently approved. He...
CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice [0.03%]
利用CRISPR激活与核糖体关联的质量控制因子ASCC3可缓解小鼠的脆性X综合征表型
Ji Geng,Xiying Wang,Jie Pan et al.
Ji Geng et al.
Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X syndrome (FXS), an inherited neurodevelopmental disorder resulting in intellectual disability and autism spectrum disorder; however, the molecular function of FMRP remain...
A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge [0.03%]
一种可自我复制的RNA疫苗能够保护食蟹猴免受高致死性的H5N1病毒亚型2.3.4.4b的侵染
David W Hawman,Amanda Griffin,Natalie McCarthy et al.
David W Hawman et al.
In early 2024, clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A H5N1 virus was detected in United States dairy cattle. Although so far the public health threat of contemporary clade 2.3.4.4b H5N1 virus strains remains low, continue...
Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury [0.03%]
删除小鼠Sarm1基因产生利于外周神经损伤后再生的微环境
Ligia B Schmitd,Hannah Hafner,Ayobami Ward et al.
Ligia B Schmitd et al.
Upon injury to the mammalian peripheral nervous system (PNS), severed axons undergo rapid SARM1-dependent programmed axon death (Wallerian degeneration), but a potential role for Sarm1 in PNS regeneration remains unclear. We show that in mo...
An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques [0.03%]
一种灭活三价病毒基疫苗可保护小鼠和食蟹猴免受致脑炎的甲病毒气溶胶攻击
L K Metthew Lam,Theron Gilliland Jr,Matthew Dunn et al.
L K Metthew Lam et al.
Venezuelan (VEEV), Eastern (EEEV), and Western (WEEV) equine encephalitis viruses are mosquito-transmitted alphaviruses in the family Togaviridae with the potential to cause fatal neuroinvasive disease in humans. These viruses can also be i...
SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis [0.03%]
基于SV2A的PET影像技术揭示多发性硬化中皮层突触丢失现象
Emily M Ullrich Gavilanes,Laura M Bartos,Jonathan A Gernert et al.
Emily M Ullrich Gavilanes et al.
Gray matter pathology, including the formation of cortical lesions, predicts progression in people with multiple sclerosis (PwMS). Here, we investigated whether positron emission tomography (PET) imaging using the synaptic vesicle protein 2...