The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness [0.03%]
伯氏疏螺旋体肽聚糖可在组织中持续存在并引发全身性慢性疾病反应
Mecaila E McClune,Osamudiamen Ebohon,Jules M Dressler et al.
Mecaila E McClune et al.
Persistent symptoms after an acute infection is an emerging public health concern, but the pathobiology of such conditions is not well understood. One possible scenario involves the persistence of lingering antigen. We have previously repor...
Activation and targetability of TYMP-IL-6-TF signaling in the skin microenvironment in uremic calciphylaxis [0.03%]
尿毒症钙化磷病皮肤微环境中的TYMP-IL-6-TF信号的激活和靶向性
Marc Arthur Napoleon,Xiaosheng Yang,Yichi Zhang et al.
Marc Arthur Napoleon et al.
Calciphylaxis is an orphan disease characterized by dermal microvessel thrombosis, inflicting painful cutaneous necrosis. It occurs predominantly in patients with end-stage kidney disease and has high mortality, elusive pathogenesis, and no...
A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice [0.03%]
一种高分辨率屏幕识别出的一种现有β-内酰胺可以特异性治疗小鼠的莱姆病
Maegan E Gabby,Abey Bandara,L M Outrata et al.
Maegan E Gabby et al.
Lyme disease, caused by Borrelia burgdorferi in the United States, is an escalating human health problem that can cause severe disease if not properly treated. Doxycycline is the primary treatment option for Lyme disease; however, several c...
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis [0.03%]
谷氨酰胺特异性γ-谷氨酰环转移酶1（CHAC1）通过调节铁死亡增加肾脏疾病风险
Lakshmi P Kolligundla,Katie M Sullivan,Dhanunjay Mukhi et al.
Lakshmi P Kolligundla et al.
Genome-wide association studies (GWASs) have identified more than 1000 loci where genetic variants correlate with kidney function. However, the specific genes, cell types, and mechanisms influenced by these genetic variants remain largely u...
A microfluidic wearable device for wound exudate management and analysis in human chronic wounds [0.03%]
一种用于人体慢性伤口渗出物管理和分析的微流控可穿戴设备
Canran Wang,Kexin Fan,Ehsan Shirzaei Sani et al.
Canran Wang et al.
Chronic wounds are a major global health challenge associated with substantial economic burden and a negative impact on patient quality of life. Real-time analysis of biomarkers like reactive oxygen and nitrogen species could guide treatmen...
Gianmarco Gasperini,Norman Baylor,Steve Black et al.
Gianmarco Gasperini et al.
Artificial intelligence (AI) has already transformed vaccine antigen design and could transform the entire vaccinology pipeline, including immune responses and emerging infectious disease prediction, manufacturing and regulatory processes, ...
Condensation of cellular prion protein promotes renal fibrosis through the TBK1-IRF3 signaling axis [0.03%]
细胞型_prP_凝聚通过TBK1-IRF3信号轴促进肾纤维化
Tantan Long,Yumei Lu,Yuanyuan Ma et al.
Tantan Long et al.
Cellular prion protein (PrPC), known for its pathological isoform in prion diseases such as Creutzfeldt-Jakob disease, is primarily expressed in the nervous system but has also been detected in the blood and urine of individuals with renal ...
Expansion of a bacterial operon during cancer treatment ameliorates fluoropyrimidine toxicity [0.03%]
细菌操作子在癌症治疗过程中的扩张可缓解氟尿嘧啶类药物的毒性
Kai R Trepka,Wesley A Kidder,Than S Kyaw et al.
Kai R Trepka et al.
Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Here, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through l...
Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia [0.03%]
抗CD21嵌合抗原受体T细胞治疗T细胞急性淋巴细胞白血病的临床前开发研究
Nicola Maciocia,Malika Hoekx,Ciaran Acuna et al.
Nicola Maciocia et al.
Patients with relapsed/refractory (r/r) T cell acute lymphoblastic leukemia (T-ALL) have a dismal prognosis, highlighting the urgent need for effective therapies. Chimeric antigen receptor (CAR)-T cell approaches targeting pan-T cell antige...