Interferon regulatory factor-1-expressing astrocytes are epigenetically controlled and exacerbate TBI-associated pathology in mice [0.03%]
IRF1表达的星形胶质细胞通过表观遗传调控加重小鼠TBI相关的病理变化
Wenxing Cui,Hao Bai,Chengxuan Guo et al.
Wenxing Cui et al.
Astrocyte heterogeneity is closely associated with the pathophysiology of traumatic brain injury (TBI), particularly in the development of cerebral edema, which is a major contributor to morbidity and mortality in patients with TBI. However...
Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus [0.03%]
针对奈瑟氏球菌次优势抗原的人单克隆抗体对淋病奈瑟氏球菌具有交叉保护作用
Marco Troisi,Monica Fabbrini,Samuele Stazzoni et al.
Marco Troisi et al.
Gonococcus, a bacterium resistant to most antibiotics, causes more than 80 million cases of gonorrhea annually and is considered a high-priority pathogen by the World Health Organization. Recently, vaccine development prospects were boosted...
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19 [0.03%]
SARS-CoV-2诱发中性粒细胞脱颗粒并分化为髓源性抑制细胞与重症COVID-19相关
Leon L Hsieh,Elizabeth A Thompson,Nirvani P Jairam et al.
Leon L Hsieh et al.
Severe COVID-19 presents with a distinct immunological profile, characterized by elevated neutrophil and reduced lymphocyte counts, seen commonly in fungal and bacterial infections. This study demonstrates that patients hospitalized with CO...
In vivo CRISPR activation screen identifies acyl-CoA-binding protein as a driver of bone metastasis [0.03%]
利用体内CRISPR激活筛选技术鉴定出长链脂肪酰辅酶A结合蛋白是骨转移驱动因子
Hongqi Teng,Qinglei Hang,Caishang Zheng et al.
Hongqi Teng et al.
One of the most common sites of cancer metastasis is to the bone. Bone metastasis is associated with substantial morbidity and mortality, and current therapeutic interventions remain largely palliative. Metastasizing tumor cells need to rep...
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer [0.03%]
微卫星稳定型结直肠癌的DNA突变率异质性和演变规律
Elena Grassi,Valentina Vurchio,George D Cresswell et al.
Elena Grassi et al.
Historically, DNA sequence mutability has been considered relatively uniform and low in tumors with chromosomal instability (CIN), based on the assumption that high mutability would be detrimental in karyotypically aberrant contexts. Recent...
Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1-induced platelet reactivity [0.03%]
依洛沙班通过抑制环氧化酶-1诱导的血小板反应减少动脉血栓形成
Philipp Mourikis,Marcel Benkhoff,Laura Wildeis et al.
Philipp Mourikis et al.
Large, randomized trials testing omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation to reduce cardiovascular events have reported contradictory results. Interpretation of these trials is challenging, because different dosages an...
An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study [0.03%]
一种口服诺如病毒疫苗能生成黏膜免疫并在二期安慰剂对照试验中减少病毒释放
Becca A Flitter,Joshua Gillard,Susan N Greco et al.
Becca A Flitter et al.
There are currently no licensed vaccines for norovirus, a leading cause of epidemic and endemic gastroenteritis worldwide. Clinical advancement of promising vaccine candidates from phase 2 studies to phase 3 field trials has been hampered b...
Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models [0.03%]
一种基于修饰人的前弹力蛋白的密封剂在临床前模型中快速闭合并止血破裂的软组织中的作用研究
Mahsa Ghovvati,Saumya Jain,George Z Cheng et al.
Mahsa Ghovvati et al.
Treatment of injuries to soft elastic organs is often hindered by challenging anatomical features and limitations of existing sealant materials, which may lack adequate tissue adhesion, elasticity, biocompatibility, and effective hemostatic...
Expanded T cell clones with lymphoma driver somatic mutations accumulate in refractory celiac disease [0.03%]
克利夫病中带有淋巴瘤驱动突变的T细胞克隆扩增
Mandeep Singh,Raymond H Y Louie,Jerome Samir et al.
Mandeep Singh et al.
Intestinal inflammation continues in a subset of patients with celiac disease despite a gluten-free diet. Here, by applying multi-omic single-cell analysis to duodenal biopsies, we found that low-grade malignancies with lymphoma driver muta...
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease [0.03%]
MEK1/2抑制剂可抑制帕金森病细胞模型和人类化小鼠模型中的病理α-突触核蛋白和神经毒性
Huilan Wang,Qing Wang,Haoxiang Xu et al.
Huilan Wang et al.
The abnormal accumulation of misfolded proteins is a common hallmark of many neurodegenerative disorders. Among these proteins, α-synuclein (αsyn) is a well-characterized pathogenic protein in Parkinson's disease (PD) and other synucleino...