Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors [0.03%]
甲氨蝶呤发挥抗肿瘤免疫作用并改善实体瘤患者免疫治疗的临床疗效
Ruirui Yang,Bei Wang,Zhaoming Su et al.
Ruirui Yang et al.
Low-dose methotrexate (MTX) is the first-line drug for treating rheumatoid arthritis as an immunosuppressor. We have identified that low-dose MTX exhibits antitumor immune activity. MTX treatment reduced tumor metastasis and enhanced the ef...
A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections [0.03%]
一种模仿宿主防御肽的前药，可被耐药革兰氏阴性细菌感染激活
Jiayang Xie,Min Zhou,Zihao Cong et al.
Jiayang Xie et al.
The high mortality of drug-resistant Gram-negative bacterial infections and the scarcity of antibiotics against Gram-negative bacteria urgently call for effective antimicrobial agents. Antimicrobial polymers that mimic host defense peptides...
A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint [0.03%]
一项一期临床试验显示腺相关病毒介导的IL-1Ra在人骨关节炎膝关节内的安全和持续表达
Rodolfo E De la Vega,Jacob L Sellon,Jay Smith et al.
Rodolfo E De la Vega et al.
Osteoarthritis (OA) is a major global health problem with no disease-modifying therapies. Interleukin-1 (IL-1) is a critical cytokine associated with the pathophysiology of OA and can be inhibited by IL-1 receptor antagonist (IL-1Ra). Here,...
IFN-γ-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models [0.03%]
IFN-γ抵抗的CD28 CAR-T细胞在多个小鼠肿瘤模型中表现出更长的存活时间，更高的有效性和持续性
Stefanie R Bailey,Hana N Takei,Giulia Escobar et al.
Stefanie R Bailey et al.
Interferon-γ (IFN-γ) plays complex and, sometimes, contradictory roles in cancer, which can affect patient responses to treatments such as immunotherapies. We recently demonstrated that IFN-γ production by chimeric antigen receptor (CAR)...
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes [0.03%]
健康成人免疫类型纵向稳定的T细胞功能和固有免疫激活特点
Megan E Smithmyer,Alex Hu,Matthew J Dufort et al.
Megan E Smithmyer et al.
Understanding the variability of immune cell composition and responsiveness in health is critical to define changes that predict and explain immune-associated diseases like autoimmunity and cancer. Here, we comprehensively phenotyped a coho...
MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis [0.03%]
多发性硬化症中细胞外囊泡递送的microRNA-142-3p标记调节性T细胞功能障碍
Giusy De Rosa,Claudia Russo,Silvia Garavelli et al.
Giusy De Rosa et al.
CD4+CD25hiFoxP3+ regulatory T cells (Treg cells) are key controllers of immune self-tolerance, and their suppressive function is impaired in people with relapsing-remitting multiple sclerosis (pwRR-MS). Because the mechanisms underlying thi...
Anti-inflammatory, but not lipid-lowering, activity of hepatocyte PPARα improves atherosclerosis in Ldlr- deficient mice [0.03%]
肝细胞PPARα的抗炎而非降脂作用可改善Ldlr缺陷小鼠的动脉粥样硬化病情
Doriane Henry,Eric Baugé,Nathalie Hennuyer et al.
Doriane Henry et al.
Atherogenic dyslipidemia and chronic inflammation appear strongly associated with residual cardiovascular disease (CVD) risk. Peroxisome proliferator-activated receptor α (PPARα) agonists, which exert both triglyceride-lowering and anti-i...
Peripherally induced RORγt+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy [0.03%]
RORγt阳性驻留调节性T细胞的外周诱导介导了过敏原特异性免疫疗法的效果
KeLun Zhang,Su Min Kim,Ho-Keun Kwon et al.
KeLun Zhang et al.
Skin-resident regulatory T cells (Treg cells) cells play a critical role in subcutaneous allergen-specific immunotherapy (SIT) for atopic dermatitis (AD). However, a detailed description of the phenotype and origin of skin-resident Treg cel...
Systemic delivery of cadherin 17-specific CAR T cells allows effective and safe targeting of colorectal cancer liver metastases [0.03%]
靶向结直肠癌肝转移的闭合素17特异性嵌合抗原受体T细胞的系统递送有效且安全
Beatrice Greco,Rita El Khoury,Chiara Balestrieri et al.
Beatrice Greco et al.
Liver metastases represent the leading cause of death in patients with colorectal cancer (CRC). Chimeric antigen receptor (CAR) T cell therapy holds promise in this context, but any effort to bring it to the bedside requires careful antigen...
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males [0.03%]
出血性创伤后生物女性较男性更易因gasdermin D诱导的系统性炎症风暴而致死
Xuejing Sun,Sultan S Abdelhamid,Zachary Secunda et al.
Xuejing Sun et al.
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with incre...