Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variants compared with Alpha variant in vaccinated individuals [0.03%]
与阿尔法变异株相比新型冠状病毒疫苗对贝塔、伽马和德尔塔变异株的保护效力减弱
Stijn P Andeweg,Harry Vennema,Irene Veldhuijzen et al.
Stijn P Andeweg et al.
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from in...
A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers [0.03%]
一种塞马福林-plexin-Rasal1信号通路通过抑制胃泌素的表达保护机体免受消化性溃疡的侵害
Rui Xu,Carsten Höß,Jakub M Swiercz et al.
Rui Xu et al.
Peptic ulcer disease is a frequent clinical problem with potentially serious complications such as bleeding or perforation. A decisive factor in the pathogenesis of peptic ulcers is gastric acid, the secretion of which is controlled by the ...
Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial [0.03%]
针对重症COVID-19患者的星形聚合纳米药物治疗可减轻炎症和神经损伤标志物并改善临床结果（IIa期临床试验）
Aaron M Gusdon,Nauder Faraday,John S Aita et al.
Aaron M Gusdon et al.
Hyperinflammation triggered by SARS-CoV-2 is a major cause of disease severity, with activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine dendrimer-N-acetylcysteine conjugate that specifically targets activat...
Randomized Controlled Trial
Science translational medicine. 2022 Jul 20;14(654):eabo2652. DOI:10.1126/scitranslmed.abo2652 2022
Improving the diagnosis of severe malaria in African children using platelet counts and plasma Pf HRP2 concentrations [0.03%]
利用血小板计数和血浆Pf HRP2浓度改善非洲儿童严重疟疾的诊断
James A Watson,Sophie Uyoga,Perpetual Wanjiku et al.
James A Watson et al.
Severe malaria caused by Plasmodium falciparum is difficult to diagnose accurately in children in high-transmission settings. Using data from 2649 pediatric and adult patients enrolled in four studies of severe illness in three countries (B...
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity [0.03%]
脂质连接的免疫原鼻内疫苗促进抗原跨黏膜摄取以驱动粘膜和全身免疫反应
Brittany L Hartwell,Mariane B Melo,Peng Xiao et al.
Brittany L Hartwell et al.
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry. Immunization directly through airway surfaces is effective in driving mucosa...
Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor [0.03%]
利用体内递送的mini dCas13X衍生RNA碱基编辑器矫正常染色体显性遗传听力损失
Qingquan Xiao,Zhijiao Xu,Yuanyuan Xue et al.
Qingquan Xiao et al.
Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing the potential risk associated with permanent genetic changes associated with the use of DNA editing tools. However, the potential of these RNA t...
Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling [0.03%]
白细胞介素-6依赖的上皮液体化启动肺纤维化重塑反应
Ian T Stancil,Jacob E Michalski,Corinne E Hennessy et al.
Ian T Stancil et al.
Chronic disease results from the failure of tissues to maintain homeostasis. In the lung, coordinated repair of the epithelium is essential for preserving homeostasis. In animal models and human lung disease, airway epithelial cells mobiliz...
Francis C Szoka Jr
Francis C Szoka Jr
PEGylated lipid protein immunogens delivered intranasally to mice and macaques drive production of IgG and IgA antibodies at other mucosal sites (Hartwell et al.).
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma [0.03%]
靶向调控PAX3-FOXO1阳性性横纹肌肉瘤中的KDM4因子
Shivendra Singh,Ahmed Abu-Zaid,Hongjian Jin et al.
Shivendra Singh et al.
Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3-Forkhead...
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models [0.03%]
靶向诱导递送免疫活化细胞因子可重新编程胶质母细胞瘤微环境并抑制小鼠模型中的肿瘤生长
Filippo Birocchi,Melania Cusimano,Federico Rossari et al.
Filippo Birocchi et al.
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also for the development of effective immunotherapies. The possibil...