Mark E Peeples
Mark E Peeples
In clinical trials, RSV prefusion F protein induced higher neutralizing antibodies and more activated memory B cells than postfusion F protein (Chang et al.).
Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium [0.03%]
持续的新冠嗅觉丧失与嗅粘膜免疫细胞浸润和基因表达改变相关
John B Finlay,David H Brann,Ralph Abi Hachem et al.
John B Finlay et al.
SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and ...
Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes [0.03%]
线粒体DNA大片段缺失综合征儿童的造血干细胞的线粒体增强效应
Elad Jacoby,Omer Bar-Yosef,Noah Gruber et al.
Elad Jacoby et al.
Patients with single large-scale mitochondrial DNA (mtDNA) deletion syndromes (SLSMDs) usually present with multisystemic disease, either as Pearson syndrome in early childhood or as Kearns-Sayre syndrome later in life. No disease-modifying...
A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine [0.03%]
前融合稳定型RSV F亚单元疫苗诱导的B细胞反应比后融合F疫苗具有更广和更强的反应
Lauren A Chang,Emily Phung,Michelle C Crank et al.
Lauren A Chang et al.
There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and...
A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity [0.03%]
针对非连接蛋白-1的单克隆抗体通过调节细胞可塑性来抑制患者衍生模型中的纤维化
Natascha Roehlen,Antonio Saviano,Houssein El Saghire et al.
Natascha Roehlen et al.
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the t...
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling [0.03%]
人类β-防御素2通过限制回肠中中性粒细胞的浸润和抑制T细胞受体信号传导来改善急性GVHD
Tamina Rückert,Geoffroy Andrieux,Melanie Boerries et al.
Tamina Rückert et al.
Acute graft-versus-host disease (aGVHD), which is driven by allogeneic T cells, has a high mortality rate and limited treatment options. Human β-defensin 2 (hBD-2) is an endogenous epithelial cell-derived host-defense peptide. In addition ...
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis [0.03%]
针对Netherton综合征和特应性皮炎的KLK5和KLK7的双抗体抑制作用
Joseph Chavarria-Smith,Cecilia P C Chiu,Janet K Jackman et al.
Joseph Chavarria-Smith et al.
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal ...
Combination bezafibrate and nivolumab treatment of patients with advanced non-small cell lung cancer [0.03%]
贝扎夫ibrate和nivolumab联合治疗晚期非小细胞肺癌患者
Kentaro Tanaka,Kenji Chamoto,Sho Saeki et al.
Kentaro Tanaka et al.
Despite the success of cancer immunotherapies such as programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibitors, patients often develop resistance. New combination therapies with PD-1/PD-L1 inhibitors are needed to overcome this i...
A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates [0.03%]
单剂量ChAd3-MARV疫苗可快速并长期地保护非人类灵长类动物免受马堡病毒的侵害
Ruth Hunegnaw,Anna N Honko,Lingshu Wang et al.
Ruth Hunegnaw et al.
Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category A bioterrorism agent by the Centers for Disease Control and Prevention (CDC) and ...