Metabolic surgery reduces CRC disease progression through circulating bile acid diversion [0.03%]
代谢手术通过循环胆酸分流减少结直肠癌疾病进展
Claudia Lässle,Bernhard Mauerer,Lisa Marx et al.
Claudia Lässle et al.
Obesity is a global epidemic characterized by energy disequilibrium, metabolic disorders, and fat mass development that greatly affect the health status of individuals. There is evidence that the intake of a high-fat diet and overweight are...
Elizabeth R M Zunica,Vance L Albaugh
Elizabeth R M Zunica
Bile diversion in preclinical Roux-en-Y gastric bypass confers its antitumor effects independently of weight loss (Lässle et al., this issue).
Core-shell microcapsules compatible with routine injection enable prime/boost immunization against malaria with a single shot [0.03%]
核心-壳结构微胶囊兼容常规注射手段使单次注射联合免疫成为可能用于疟疾免疫接种
Romain Guyon,Sören Reinke,Adam Truby et al.
Romain Guyon et al.
Inadequate booster uptake threatens the success of immunization campaigns as seen with the recently rolled-out R21 malaria vaccine. The ability to administer both prime and boost immunizations with a single injection would therefore save li...
Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans [0.03%]
小鼠和人类肾小球上皮增生性疾病的 podocyte YAP 和 TAZ 超活化驱动机制
Xiaolin He,Estefania Rodriguez Ballestas,Li Zeng et al.
Xiaolin He et al.
Kidney diseases characterized by glomerular epithelial cell proliferation are rare but often devastating, frequently leading to progressive scarring and renal failure. Ranging from autoimmune-induced crescentic glomerulonephritis to HIV inf...
Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells [0.03%]
podocytes中YAP的活化通过与尿囊上皮细胞相互作用触发新月体性肾小球肾炎
Lisa Turinsky,Sonja Rehrl,Clément Nguyen et al.
Lisa Turinsky et al.
Crescentic glomerulonephritis (cGN) is a severe kidney pathology characterized by the aberrant proliferation of epithelial cells, leading to crescent formation within the Bowman's space. The molecular pathways involved in crescent formation...
OX40-heparan sulfate binding facilitates CAR T cell penetration into solid tumors in mice [0.03%]
OX40-肝糖胺聚糖结合促进CAR-T细胞在小鼠实体瘤中浸润
Huihui Zhang,Runbo Zhong,Wanting Wang et al.
Huihui Zhang et al.
Although chimeric antigen receptor (CAR)-modified T cells have shown great success in treating B cell malignancies, they have demonstrated only limited efficacy against solid tumors. Here, we designed a CAR by integrating an antigen-indepen...
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion [0.03%]
结合缓慢释放和滤泡定位的抗原疫苗可增加生发中心B细胞多样性及克隆型扩增
Kristen A Rodrigues,Yiming J Zhang,Jonathan Lam et al.
Kristen A Rodrigues et al.
Vaccine adjuvants play important roles in shaping the humoral response to immunization. Here, we analyzed mechanisms of action of a clinically relevant combination adjuvant strategy, where phosphoserine (pSer)-tagged immunogens bound to alu...
ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy [0.03%]
腺苷酸cyclase相关基质金属蛋白酶5抑制可减轻杜氏肌营养不良小鼠模型的肌肉炎症和纤维化并改善功能
John Dulos,Danielle A Debruin,Ellen van der Aar et al.
John Dulos et al.
In muscles of patients with Duchenne muscular dystrophy (DMD), expression of extracellular matrix proteases and proteoglycans, including A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) and its substrates versican...
Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer [0.03%]
合成生物学驱动的成熟TLS形成诱导可增强结直肠癌的抗肿瘤免疫能力
Ze Mi,Juan Chen,Zhewen Zhang et al.
Ze Mi et al.
The efficacy of immunotherapy in colorectal cancer (CRC) hinges upon a comprehensive understanding of how the immune system interacts with tumor cells within the colorectal microenvironment. Mature tertiary lymphoid structures (mTLSs) are a...
Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models [0.03%]
利用巨噬细胞药物偶联物的过继性细胞疗法促进胶质母细胞瘤模型中细胞毒药物转移和免疫激活
Miaomiao Sun,Maciej Bialasek,Maud Mayoux et al.
Miaomiao Sun et al.
The treatment of solid tumors faces substantial hurdles because of inadequate drug delivery and the immunosuppressive tumor microenvironment. To address these challenges, we developed a therapeutic platform using macrophages loaded with fer...