Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model [0.03%]
Aikaterini Smaragdi Papadopoulou,Julia Alterman,Christian Landles et al.
Aikaterini Smaragdi Papadopoulou et al.
Lowering huntingtin (HTT) transcript levels has been a major focus of therapeutic development for Huntington's disease (HD), but which transcript should be lowered? HD is caused by a CAG repeat expansion in exon 1 of the HTT gene, and the r...
Patient-derived xenograft models of primary breast cancer for preclinical evaluation of neoadjuvant therapies [0.03%]
Stefan J Hutten,Xue Chao,Madelon Badoux et al.
Stefan J Hutten et al.
Targeted therapies are important for invasive breast cancer (IBC) treatment but are generally not standard of care in the neoadjuvant setting. To identify therapies with the potential to improve neoadjuvant treatment response, it is essenti...
Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes [0.03%]
Chris Greene,Declan Brennan,Sheida Mirloo et al.
Chris Greene et al.
Cerebrovascular disruption has been implicated in the pathophysiology of head trauma and chronic traumatic encephalopathy (CTE). However, the long-term consequences of repetitive head trauma on blood-brain barrier (BBB) integrity and its li...
Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington's disease mice [0.03%]
Robert M Bragg,Christian Landles,Edward J Smith et al.
Robert M Bragg et al.
Huntington's disease (HD) arises from the toxic gain of function caused by a CAG expansion in the coding region of the huntingtin (HTT) gene. HD is increasingly appreciated to emerge from multiple pathogenic processes, including somatic ins...
Disruption of the oligodendroglial miR-126a-3p- Pex5 axis inhibits remyelination in chronic demyelinating lesions [0.03%]
Qi Shao,Zhenghao Li,Weixing Tan et al.
Qi Shao et al.
Insufficient maturation of oligodendrocyte progenitor cells (OPCs) contributes to the failure of endogenous remyelination in multiple sclerosis (MS). It remains unclear whether dysregulated oligodendroglial microRNAs (miRNAs) impede remyeli...
Amyloid-β as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency [0.03%]
Chia-Ling Tu,Zhiqiang Cheng,Nicholas Szeto et al.
Chia-Ling Tu et al.
Hyperparathyroidism is an endocrine disorder linked to vitamin D deficiency. Reduced vitamin D receptor (VDR) activity promotes parathyroid hormone (PTH) hypersecretion by increasing heterodimerization of the type B γ-aminobutyric acid rec...
Dual-positive CTCs in patients with advanced breast cancer show metastatic potential and prognostic value [0.03%]
双重阳性的循环肿瘤细胞对乳腺癌患者具有转移能力和预后价值
Carolina Reduzzi,Eleonora Nicolò,Lorenzo Gerratana et al.
Carolina Reduzzi et al.
Metastasis is the leading cause of death in patients with breast cancer (BC), but the mechanisms underlying metastasis formation are still poorly understood. Circulating tumor cells (CTCs) are considered the main seed of metastasis with dem...
Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications [0.03%]
人子宫移植后NFAT抑制促进组织驻留NK细胞的丧失及伴随而来的妊娠并发症
Rebecca Asiimwe,Brittney Knott,Morgan E Greene et al.
Rebecca Asiimwe et al.
Uterine natural killer (uNK) cells are a tissue-resident lymphocyte population critical for pregnancy success. Although mouse models have demonstrated that uNK cell deficiency results in abnormal placentation and poor pregnancy outcomes, th...
Sonresa R Molina-Vidales,Monique M Poulson,Scott M Gordon
Sonresa R Molina-Vidales
After human uterus transplant, all uterine immune cell lineages were reconstituted but with alterations in tissue-resident NK cells, potentially due to tacrolimus (Asiimwe et al. and Strunz et al., this issue).