Effect of spironolactone and cyproterone acetate on breast growth in transgender people: a randomized clinical trial [0.03%]
螺内酯和醋酸环丙孕酮对跨性别者乳房发育的影响：随机临床试验
Lachlan M Angus,Shalem Y Leemaqz,Anna K Kasielska-Trojan et al.
Lachlan M Angus et al.
Context: Transgender people with sex recorded male at birth desiring feminization commonly use cyproterone acetate or spironolactone as anti-androgens with estradiol, but the optimal anti-androgen is unclear. ...
PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas [0.03%]
PCSK1N作为促肾上腺皮质激素垂体腺瘤的肿瘤大小标志物和内质网应激反应蛋白
Merisa Abusdal,Kjersti R Normann,Tuula A Nyman et al.
Merisa Abusdal et al.
Purpose: Silent corticotroph adenoma (SCA) exhibits more tumor aggressiveness features than functioning adenomas (FCA). We aimed to investigate PCSK1N expression in CA and examine if ER stress-induced responses affect cel...
Association of nighttime sleep duration at 1.5 years with height at 3 years: The Japan Environment and Children's Study [0.03%]
日本环境与儿童研究中1.5岁幼儿夜间睡眠时长与3岁时身高的关联性研究
Masanobu Kawai,Sachiko Baba,Kanami Tanigawa et al.
Masanobu Kawai et al.
Context: Adequate nighttime sleep duration has been considered beneficial for linear growth in children; however, there is limited and conflicting evidence regarding the association between sleep duration and subsequent l...
Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity [0.03%]
习惯性饮用咖啡、茶和摄取咖啡因与循环代谢物及心血管代病风险的关系
Xujia Lu,Xiaohong Zhu,Guochen Li et al.
Xujia Lu et al.
Context: Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual card...
Serum phosphate in the general population: a need for sex-specific reference intervals [0.03%]
正常人群血磷的性别特异性参考区间
Ariadne Bosman,Natalia Campos-Obando,Christian Ramakers et al.
Ariadne Bosman et al.
Background: Phosphate is important for several metabolic functions and essential for bone mineralization. Sex-differences exist in the relation between serum phosphate and certain diseases. The reference interval for phos...
1-Hour Post-Load Glucose: Early Screening for High Risk of Type 2 Diabetes in Koreans with Normal Fasting Glucose [0.03%]
正常空腹血糖的韩国人中早筛2型糖尿病高危人群的一小时负荷后血糖筛查
Min Jin Lee,Ji Hyun Bae,Ah Reum Khang et al.
Min Jin Lee et al.
Context: With rising the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes, the importance of 1-hour post-load plasma glucose (1-h PG) for early hyperglycemia screening is emphasized. ...
Topiramate added to metformin for obesity control in women with polycystic ovary syndrome: a randomized clinical trial [0.03%]
二甲双胍联合托吡酯治疗多囊卵巢综合征女性肥胖的随机临床试验
Lucas Bandeira Marchesan,Thais Rasia da Silva,Poli Mara Spritzer
Lucas Bandeira Marchesan
Context: Polycystic ovary syndrome (PCOS) is often linked with obesity, and weight management can improve endocrine and cardiometabolic features. Objectiv...
Somapacitan in Children Born SGA: 52-week Efficacy, Safety, and IGF-I Response Results from the Phase 2 REAL5 Study [0.03%]
一项II期研究REAL5的52周疗效、安全性和IGF-I反应结果：对SGA出生儿的疗效、安全性和IGF-I反应结果
Anders Juul,Philippe Backeljauw,Michael Højby et al.
Anders Juul et al.
Context: Somapacitan, a once-weekly reversible albumin-binding GH derivative, is evaluated in short children born small for gestational age (SGA). Objecti...
Data-Driven Strategies for Carbimazole Titration: Exploring Machine Learning Solutions in Hyperthyroidism Control [0.03%]
基于数据的卡比马唑滴定策略：探索甲亢控制中的机器学习解决方案
Thilo Reich,Rashid Bakirov,Dominika Budka et al.
Thilo Reich et al.
Background: University Hospitals Dorset (UHD) has over 1,000 thyroid patient contacts annually. These are primarily patients with autoimmune hyperthyroidism treated with Carbimazole titration. Dose adjustments are made by...
The effect of SGLT2 inhibition on brain-related phenotypes and aging: a drug target Mendelian randomization study [0.03%]
SGLT2抑制与脑相关表型和衰老的关联：孟德尔随机化研究
Zhihe Chen,Xueyan Wu,Qianqian Yang et al.
Zhihe Chen et al.
Introduction: Observational study suggested SGLT2 inhibitors might promote healthy aging. However, whether brain-related phenotypes mediate this association. We applied Mendelian randomization (MR) to investigate the effe...